Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

Background  The profile of intestinal organic acids in irritable bowel syndrome (IBS) and its correlation with gastrointestinal (GI) symptoms are not clear. We hypothesized in this study that altered GI microbiota contribute to IBS symptoms through increased levels of organic acids.

[1]  M. Hongo,et al.  High Prevalence of Irritable Bowel Syndrome in Medical Outpatients in Japan , 2008, Journal of clinical gastroenterology.

[2]  D. Corey,et al.  50 Novel and Specific Roles for the Ion Channel TRPA1 in Visceral Sensory Transduction , 2008 .

[3]  J. Corander,et al.  The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. , 2007, Gastroenterology.

[4]  Hinrich W. H. Göhlmann,et al.  Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice. , 2007, Gastroenterology.

[5]  P. Pasricha,et al.  The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats. , 2007, Gastroenterology.

[6]  T. Matsuki Group-specific PCR primers for the detection of human intestinal bacteria , 2007 .

[7]  D. Ardid,et al.  Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors , 2007, Nature Medicine.

[8]  O. Kajimoto,et al.  The Effects of a Probiotic Milk Product Containing Lactobacillus casei Strain Shirota on the Defecation Frequency and the Intestinal Microflora of Sub-optimal Health State Volunteers: A Randomized Placebo-controlled Cross-over Study , 2006 .

[9]  G. Locke,et al.  Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders. , 2006, Gastroenterology.

[10]  W. Jackson,et al.  Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice , 2005, Gut.

[11]  D. Drossman,et al.  A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator. , 2005, Gastroenterology.

[12]  F. Shanahan,et al.  Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. , 2005, Gastroenterology.

[13]  A. Palva,et al.  Analysis of the Fecal Microbiota of Irritable Bowel Syndrome Patients and Healthy Controls with Real-Time PCR , 2005, The American Journal of Gastroenterology.

[14]  J. Svedlund,et al.  GSRS—A clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease , 1988, Digestive Diseases and Sciences.

[15]  J. Fujimoto,et al.  Use of 16S rRNA Gene-Targeted Group-Specific Primers for Real-Time PCR Analysis of Predominant Bacteria in Human Feces , 2004, Applied and Environmental Microbiology.

[16]  L. T. Angenent,et al.  Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? , 2004, Nature Immunology.

[17]  R. Spiller Postinfectious irritable bowel syndrome1 1Abbreviations used in this paper: EC,_; IBS, irritable bowel syndrome; PI, postinfective. , 2003 .

[18]  P. Anand,et al.  Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency , 2003, The Lancet.

[19]  R. Spiller Postinfectious irritable bowel syndrome. , 2003, Gastroenterology.

[20]  J. Fujimoto,et al.  Development of 16S rRNA-Gene-Targeted Group-Specific Primers for the Detection and Identification of Predominant Bacteria in Human Feces , 2002, Applied and Environmental Microbiology.

[21]  G. Barbara,et al.  A role for inflammation in irritable bowel syndrome? , 2002, Gut.

[22]  P. Brigidi,et al.  Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. , 2001, Research in microbiology.

[23]  T. Michl,et al.  Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain , 2001, Pain.

[24]  A. Kilbourne,et al.  The impact of irritable bowel syndrome on health-related quality of life. , 2000, Gastroenterology.

[25]  M. Ohto,et al.  Quantitative analysis of bowel gas using plain abdominal radiograph in patients with irritable bowel syndrome , 2000, American Journal of Gastroenterology.

[26]  D. Julius,et al.  Capsaicin receptor in the pain pathway. , 2000, Japanese journal of pharmacology.

[27]  D. Drossman,et al.  Further validation of the IBS-QOL: a disease-specific quality-of-life questionnaire. , 2000 .

[28]  G. Taylor Recent Developments in Alexithymia Theory and Research , 2000, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[29]  K W Heaton,et al.  Functional bowel disorders and functional abdominal pain , 1999, Gut.

[30]  Gerwin C. Raangs,et al.  Variations of Bacterial Populations in Human Feces Measured by Fluorescent In Situ Hybridization with Group-Specific 16S rRNA-Targeted Oligonucleotide Probes , 1998, Applied and Environmental Microbiology.

[31]  S. Ricke,et al.  Comparison of batch culture growth and fermentation of a poultry Veillonella isolate and selected Veillonella species grown in a defined medium. , 1997, Anaerobe.

[32]  P. Whorwell,et al.  The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress , 1997, Alimentary pharmacology & therapeutics.

[33]  J. Hyams,et al.  Fecal short-chain fatty acids in patients with diarrhea-predominant irritable bowel syndrome: in vitro studies of carbohydrate fermentation. , 1996, Journal of pediatric gastroenterology and nutrition.

[34]  R. Bagby,et al.  The twenty-item Toronto Alexithymia Scale--I. Item selection and cross-validation of the factor structure. , 1994, Journal of psychosomatic research.

[35]  S. Fukudo,et al.  Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study. , 1993, Journal of clinical gastroenterology.

[36]  C. Sherbourne,et al.  The MOS 36-Item Short-Form Health Survey (SF-36) , 1992 .

[37]  H. Kikuchi,et al.  Correlation between water-holding capacity of different types of cellulose in vitro and gastrointestinal retention time in vivo of rats , 1992 .

[38]  Andrew P. Smith,et al.  Psychological stress and susceptibility to the common cold. , 1991, The New England journal of medicine.

[39]  P. Mortensen,et al.  Short-chain fatty acids and the irritable bowel syndrome: the effect of wheat bran. , 1987, Scandinavian journal of gastroenterology.

[40]  E. Lingaas,et al.  Influence of oral intake of seven different antibiotics on faecal short-chain fatty acid excretion in healthy subjects. , 1986, Scandinavian journal of gastroenterology.

[41]  T. Midtvedt,et al.  Short-chain fatty acids in the small-bowel bacterial overgrowth syndrome. , 1985, Scandinavian journal of gastroenterology.

[42]  F. Hegazi,et al.  Degradation of organic acids by dairy lactic acid bacteria. , 1980, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite naturwissenschaftliche Abteilung: Mikrobiologie der Landwirtschaft der Technologie und des Umweltschutzes.

[43]  W. Zung A SELF-RATING DEPRESSION SCALE. , 1965, Archives of general psychiatry.