Steroidogenesis in ovarian‐like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms

Mucinous cystic neoplasms (MCNs) occur in the ovary, pancreas, and retroperitoneum but very rarely in the liver. Mucinous cystic neoplasms are known to harbor ovarian‐like mesenchymal stroma (OLS) expressing progesterone and estrogen receptors. In this study we evaluated steroidogenesis in OLS of 25 hepatic MCNs and 24 pancreatic MCNs.

[1]  R. Kurman,et al.  Steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors: a potential mechanism in ovarian tumorigenesis , 2017, Modern Pathology.

[2]  Takashi Suzuki,et al.  Immunohistochemical analysis of steroidogenic enzymes in ovarian‐type stroma of pancreatic mucinous cystic neoplasms: Comparative study of subepithelial stromal cells in intraductal papillary mucinous neoplasms of the pancreas , 2016, Pathology international.

[3]  M. Ohmichi,et al.  Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis , 2012, Journal of Ovarian Research.

[4]  A. Franchitto,et al.  Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone. , 2011, American journal of physiology. Gastrointestinal and liver physiology.

[5]  B. Portmann,et al.  Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct , 2011, Modern Pathology.

[6]  L. Carbillon,et al.  Accessory ovary in the utero-ovarian ligament: an incidental finding , 2011, Archives of Gynecology and Obstetrics.

[7]  R. Doi,et al.  Clinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma: A Multi-Institutional Study of the Japan Pancreas Society , 2011, Pancreas.

[8]  W. Lamers,et al.  Mucinous Cystadenomas in Liver: Management and Origin , 2010, Digestive Surgery.

[9]  F. Bosman,et al.  WHO Classification of Tumours of the Digestive System , 2010 .

[10]  M. Mino‐Kenudson,et al.  Mucinous Cystic Neoplasm of the Pancreas is Not an Aggressive Entity: Lessons From 163 Resected Patients , 2008, Annals of surgery.

[11]  P. Čičovački.  SOCIETY , 2008, Society.

[12]  M. Yeh,et al.  Ovarian-type stroma in hepatobiliary cystadenomas and pancreatic mucinous cystic neoplasms: an immunohistochemical study. , 2008, American journal of clinical pathology.

[13]  W. Lamers,et al.  Cystadenomas with Ovarian Stroma in Liver and Pancreas: An Evolving Concept , 2006, Digestive Surgery.

[14]  S. Davis,et al.  Androgen levels in adult females: changes with age, menopause, and oophorectomy. , 2005, The Journal of clinical endocrinology and metabolism.

[15]  Y. Wang,et al.  Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. , 2004, Molecular endocrinology.

[16]  M. Lim,et al.  Two Dermoid Cysts Developing in An Accessory Ovary and An Eutopic Ovary , 2004, Journal of Korean medical science.

[17]  Chun Xing Li,et al.  Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing. , 2004, Molecular endocrinology.

[18]  K. Cureton,et al.  Comparison of serum testosterone and androstenedione responses to weight lifting in men and women , 2004, European Journal of Applied Physiology and Occupational Physiology.

[19]  H. Perry,et al.  Androgens and women at the menopause and beyond. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[20]  Jiong Zhou,et al.  Liver Receptor Homologue-1 (LRH-1) Regulates Expression of Aromatase in Preadipocytes* , 2002, The Journal of Biological Chemistry.

[21]  McCluggage Wg.  Value of inhibin staining in gynecological pathology. , 2001 .

[22]  D. Collins,et al.  Metabolism of Dihydrotestosterone in Human Liver: Importance of 3α- and 3β-Hydroxysteroid Dehydrogenase1 , 1999 .

[23]  Robert N. Taylor,et al.  Oestrogen receptor (ER)-α and ER-β isoforms in normal endometrial and endometriosis-derived stromal cells , 1999 .

[24]  Shuk-Mei Ho,et al.  Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells , 1999 .

[25]  R. Becker,et al.  Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. , 1999, The American journal of surgical pathology.

[26]  K. Itani,et al.  Hepatobiliary Cystadenoma with Mesenchymal Stroma , 1990, Annals of surgery.

[27]  D. Mutch,et al.  Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody. , 1986, Cancer research.

[28]  H. Edmondson,et al.  Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts. A clinicopathologic study of 17 cases, 4 with malignant change , 1985, Cancer.

[29]  E B Cox,et al.  Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. , 1985, Archives of pathology & laboratory medicine.

[30]  L. Rosenberg,et al.  A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. , 1983, The Journal of surgical research.

[31]  R. Greenblatt,et al.  Ovarian and Adrenal Steroid Production in the Postmenopausal Woman , 1976, Obstetrics and gynecology.