Consequences of Transforming Measures of Efficacy for Acute Therapies: 5‐HT1B/1D Agonists as a Worked Example

Objective.—To examine whether the distributions of active and placebo response rates change after transformation into therapeutic gains, numbers needed to treat, and therapeutic ratios for 51 published clinical trials of 5‐HT1B/1D agonists in the acute treatment of migraine.

[1]  A. Fox,et al.  Comparison of Therapeutic Gain With Therapeutic Ratio for the Assessment of Selective 5HT1B/1D Agonist Efficacy in Migraine , 2002, Headache.

[2]  R. Moore,et al.  Pharmacological treatments for acute migraine: quantitative systematic review , 2002, Pain.

[3]  P. Tfelt-Hansen.  Triptan medications to treat acute migraine , 2002, The Lancet.

[4]  D. Kernick.  Triptan medications to treat acute migraine , 2002, The Lancet.

[5]  R. Lipton,et al.  Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials , 2001, The Lancet.

[6]  A. Fox,et al.  Differentiating the Efficacy of 5‐HT1B/1D Agonists , 2001, Headache.

[7]  A. Fox,et al.  Comparative Tolerability of Oral 5‐HT1B/1D Agonists , 2000, Headache.

[8]  H-C Diener,et al.  Comparison of the Efficacy of Zolmitriptan and Sumatriptan: Issues in Migraine Trial Design , 2000, Cephalalgia : an international journal of headache.

[9]  E. Spierings.  Therapeutic gain: a critique. , 1999, Headache.

[10]  R. Jaffe.  Comprehensive/tertiary care for headache. , 1999, Headache.

[11]  P. Goadsby.  Response to "Therapeutic gain: A critique" , 1999 .

[12]  M. Ferrari,et al.  How to assess and compare drugs in the management of migraine: success rates in terms of response and recurrence. , 1999, Cephalalgia : an international journal of headache.

[13]  P. Tfelt-Hansen.  Efficacy and Adverse Events of Subcutaneous, Oral, and Intranasal Sumatriptan Used for Migraine Treatment: A Systematic Review Based on Number Needed To Treat , 1998, Cephalalgia : an international journal of headache.

[14]  J. Villar,et al.  Predictive ability of meta-analyses of randomised controlled trials , 1995, The Lancet.

[15]  D. Sackett,et al.  The number needed to treat: a clinically useful measure of treatment effect , 1995 .