A Correspondence Between Normalization Strategies in Artificial and Biological Neural Networks

A fundamental challenge at the interface of machine learning and neuroscience is to uncover computational principles that are shared between artificial and biological neural networks. In deep learning, normalization methods, such as batch normalization, weight normalization, and their many variants, help to stabilize hidden unit activity and accelerate network training, and these methods have been called one of the most important recent innovations for optimizing deep networks. In the brain, homeostatic plasticity represents a set of mechanisms that also stabilize and normalize network activity to lie within certain ranges, and these mechanisms are critical for maintaining normal brain function. In this survey, we discuss parallels between artificial and biological normalization methods at four spatial scales: normalization of a single neuron’s activity, normalization of synaptic weights of a neuron, normalization of a layer of neurons, and normalization of a network of neurons. We argue that both types of methods are functionally equivalent — i.e., they both push activation patterns of hidden units towards a homeostatic state, where all neurons are equally used — and that such representations can increase coding capacity, discrimination, and regularization. As a proof of concept, we develop a neural normalization algorithm, inspired by a phenomena called synaptic scaling, and show that this algorithm performs competitively against existing normalization methods on several datasets. Overall, we hope this connection will inspire machine learners in three ways: to uncover new normalization algorithms based on established neurobiological principles; to help quantify the trade-offs of different homeostatic plasticity mechanisms used in the brain; and to offer insights about how stability may not hinder, but may actually promote, plasticity.