In vivo He-3 MR images of guinea pig lungs.

The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired with ventilation-gated, radial k-space sampling showed complete ventilation of both lungs. All images were of high quality, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.

[1]  J. Schenck,et al.  An efficient, highly homogeneous radiofrequency coil for whole-body NMR imaging at 1.5 T , 1985 .

[2]  M. Bouchiat,et al.  Nuclear Polarization in He 3 Gas Induced by Optical Pumping and Dipolar Exchange , 1960 .

[3]  Cummings,et al.  Optical pumping of Rb vapor using high-power Ga1-xAlxAs diode laser arrays. , 1995, Physical review. A, Atomic, molecular, and optical physics.

[4]  W. Happer,et al.  Biological magnetic resonance imaging using laser-polarized 129Xe , 1994, Nature.

[5]  W. Happer,et al.  Efficiency of Spin Exchange between Rubidium Spins and Xe 129 Nuclei in a Gas , 1982 .

[6]  C. Ahn,et al.  A generalized formulation of diffusion effects in micron resolution nuclear magnetic resonance imaging. , 1989, Medical physics.

[7]  P. Callaghan,et al.  Diffusion-limited resolution in nuclear magnetic resonance microscopy , 1988 .

[8]  Coulter,et al.  Polarized, high-density, gaseous 3He targets. , 1987, Physical review. C, Nuclear physics.

[9]  G. K. Walters,et al.  Nature of Surface-Induced Nuclear-Spin Relaxation of Gaseous He 3 , 1969 .

[10]  L W Hedlund,et al.  Magnetic resonance microscopy of the rat thorax and abdomen. , 1986, Investigative radiology.

[11]  R. Gamblin,et al.  POLARIZATION AND RELAXATION PROCESSES IN He$sup 3$ GASES , 1965 .

[12]  J R MacFall,et al.  MR microscopy of the rat lung using projection reconstruction , 1993, Magnetic resonance in medicine.

[13]  L. Hedlund,et al.  MR Imaging with Hyperpolarized 3He Gas , 1995, Magnetic resonance in medicine.