Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity
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[1] S. Srikantan,et al. The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. , 2014, Human molecular genetics.
[2] M. Heymann,et al. Mosaicism in HIF2A-related polycythemia-paraganglioma syndrome. , 2014, The Journal of clinical endocrinology and metabolism.
[3] K. Heimdal,et al. Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis. , 2014, European journal of endocrinology.
[4] P. Dahia. The genetic landscape of pheochromocytomas and paragangliomas: somatic mutations take center stage. , 2013, The Journal of clinical endocrinology and metabolism.
[5] G. Cote,et al. The characterization of pheochromocytoma and its impact on overall survival in multiple endocrine neoplasia type 2. , 2013, The Journal of clinical endocrinology and metabolism.
[6] David T. W. Jones,et al. Signatures of mutational processes in human cancer , 2013, Nature.
[7] Dudley Lamming,et al. A Central role for mTOR in lipid homeostasis. , 2013, Cell metabolism.
[8] R. Deberardinis,et al. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. , 2013, Molecular cell.
[9] A. Tabarin,et al. One-year progression-free survival of therapy-naive patients with malignant pheochromocytoma and paraganglioma. , 2013, The Journal of clinical endocrinology and metabolism.
[10] Thomas M. Wasylenko,et al. Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells , 2013, Nature Communications.
[11] K. Shokat,et al. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers , 2013, Proceedings of the National Academy of Sciences.
[12] Laurence Amar,et al. SDH mutations establish a hypermethylator phenotype in paraganglioma. , 2013, Cancer cell.
[13] S. Srikantan,et al. In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas. , 2013, Endocrine-related cancer.
[14] E. Maher. HIF2 and endocrine neoplasia: an evolving story. , 2013, Endocrine-related cancer.
[15] E. Baudin,et al. Current and Future Treatments for Malignant Pheochromocytoma and Sympathetic Paraganglioma , 2013, Current Oncology Reports.
[16] P. Hellman,et al. Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing. , 2013, The Journal of clinical endocrinology and metabolism.
[17] B. Baysal. Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors. , 2013, Biochimica et biophysica acta.
[18] G. Cecchini. Respiratory complex II: role in cellular physiology and disease. , 2013, Biochimica et biophysica acta.
[19] A. Tischler,et al. New syndrome of paraganglioma and somatostatinoma associated with polycythemia. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[20] Leslie G. Biesecker,et al. A genomic view of mosaicism and human disease , 2013, Nature Reviews Genetics.
[21] P. Meltzer,et al. Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. , 2013, Cancer discovery.
[22] D. Love,et al. Novel mutation in the TMEM127 gene associated with phaeochromocytoma , 2013, Internal medicine journal.
[23] K. Pacak,et al. First report of bilateral pheochromocytoma in the clinical spectrum of HIF2A-related polycythemia-paraganglioma syndrome. , 2013, The Journal of clinical endocrinology and metabolism.
[24] D. Fraker,et al. Inherited Mutations in Pheochromocytoma and Paraganglioma: Why All Patients Should Be Offered Genetic Testing , 2013, Annals of Surgical Oncology.
[25] G. Pita,et al. Tumoral EPAS1 (HIF2A) mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis. , 2013, Human molecular genetics.
[26] W. Kaelin,et al. The VHL/HIF axis in clear cell renal carcinoma. , 2013, Seminars in cancer biology.
[27] J. Nyengaard,et al. SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. , 2013, Cell reports.
[28] L. Mulligan,et al. Multiple Functional Effects of RET Kinase Domain Sequence Variants in Hirschsprung Disease , 2013, Human mutation.
[29] J. Prchal,et al. A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma , 2013, Journal of Molecular Medicine.
[30] Y. Bang,et al. Phase 2 study of everolimus monotherapy in patients with nonfunctioning neuroendocrine tumors or pheochromocytomas/paragangliomas , 2012, Cancer.
[31] E. Letouzé,et al. Somatic NF1 inactivation is a frequent event in sporadic pheochromocytoma. , 2012, Human molecular genetics.
[32] C. Larsson,et al. Integrative genomics reveals frequent somatic NF1 mutations in sporadic pheochromocytomas. , 2012, Human molecular genetics.
[33] A. Gimenez-Roqueplo,et al. HIF2A mutations in paraganglioma with polycythemia. , 2012, The New England journal of medicine.
[34] G. Semenza,et al. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression , 2012, Proceedings of the National Academy of Sciences.
[35] H. Shimano,et al. Identical germline mutations in the TMEM127 gene in two unrelated Japanese patients with bilateral pheochromocytoma , 2012, Clinical endocrinology.
[36] K. Brown,et al. A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma , 2012, Pigment cell & melanoma research.
[37] M. Korbonits,et al. Combined blockade of signalling pathways shows marked anti-tumour potential in phaeochromocytoma cell lines. , 2012, Journal of molecular endocrinology.
[38] E. Baudin,et al. Treatment with sunitinib for patients with progressive metastatic pheochromocytomas and sympathetic paragangliomas. , 2012, The Journal of clinical endocrinology and metabolism.
[39] Data production leads,et al. An integrated encyclopedia of DNA elements in the human genome , 2012 .
[40] Raymond K. Auerbach,et al. An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.
[41] Electron Kebebew,et al. Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia. , 2012, The New England journal of medicine.
[42] ENCODEConsortium,et al. An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.
[43] Mercedes Robledo,et al. MAX and MYC: a heritable breakup. , 2012, Cancer research.
[44] Hui Yang,et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. , 2012, Genes & development.
[45] Morag Park,et al. Dynamics of receptor trafficking in tumorigenicity. , 2012, Trends in cell biology.
[46] A. Vénisse,et al. A Decade (2001–2010) of Genetic Testing for Pheochromocytoma and Paraganglioma , 2012, Hormone and Metabolic Research.
[47] X. Jeunemaître,et al. Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations. , 2012, The Journal of clinical endocrinology and metabolism.
[48] M. Urioste,et al. MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma , 2012, Clinical Cancer Research.
[49] H. Affres,et al. TMEM127 screening in a large cohort of patients with pheochromocytoma and/or paraganglioma. , 2012, The Journal of clinical endocrinology and metabolism.
[50] B. Wilson,et al. Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1 , 2012, Proceedings of the National Academy of Sciences.
[51] P. Dahia,et al. An Update on the Genetics of Paraganglioma, Pheochromocytoma, and Associated Hereditary Syndromes , 2012, Hormone and Metabolic Research.
[52] E. Baudin,et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[53] Brian Keith,et al. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression , 2011, Nature Reviews Cancer.
[54] E. Maher,et al. The genetics of phaeochromocytoma: using clinical features to guide genetic testing. , 2011, European journal of endocrinology.
[55] P. Söderkvist,et al. Genetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas. , 2011, Endocrine-related cancer.
[56] G. Cote,et al. Management of medullary thyroid carcinoma and MEN2 syndromes in childhood , 2011, Nature Reviews Endocrinology.
[57] A. Vénisse,et al. Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma. , 2011, Human molecular genetics.
[58] J. Benítez,et al. Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma , 2011, Nature Genetics.
[59] H. Moch,et al. VHL gene mutations and their effects on hypoxia inducible factor HIFα: identification of potential driver and passenger mutations. , 2011, Cancer research.
[60] Rameen Beroukhim,et al. Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. , 2011, Cancer discovery.
[61] C. Eng,et al. Germline mutations of the TMEM127 gene in patients with paraganglioma of head and neck and extraadrenal abdominal sites. , 2011, The Journal of clinical endocrinology and metabolism.
[62] William Y. Kim,et al. Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL , 2011, Journal of cellular and molecular medicine.
[63] C. Ricketts,et al. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility , 2010, Endocrine-related cancer.
[64] Mingming Jia,et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..
[65] A. Hernigou,et al. A novel TMEM127 mutation in a patient with familial bilateral pheochromocytoma. , 2011, European journal of endocrinology.
[66] C. Antonescu,et al. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations , 2010, Proceedings of the National Academy of Sciences.
[67] S. Gruber,et al. Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas. , 2010, JAMA.
[68] Agnieszka Maliszewska,et al. Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas. , 2010, Molecular endocrinology.
[69] P. Bénit,et al. SDHA is a tumor suppressor gene causing paraganglioma. , 2010, Human molecular genetics.
[70] Qicheng Ma,et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. , 2010, Molecular cell.
[71] P. Dahia,et al. Mutations of the metabolic genes IDH1, IDH2, and SDHAF2 are not major determinants of the pseudohypoxic phenotype of sporadic pheochromocytomas and paragangliomas. , 2010, The Journal of clinical endocrinology and metabolism.
[72] W. Dinjens,et al. Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas. , 2010, The Journal of clinical endocrinology and metabolism.
[73] Patricia L. M. Dahia,et al. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma , 2010, Nature Genetics.
[74] P. M. Dahia,et al. VHL disease. , 2010, Best practice & research. Clinical endocrinology & metabolism.
[75] P. Bénit,et al. The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas , 2009, PloS one.
[76] Steven P. Gygi,et al. SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma , 2009, Science.
[77] H. Gharib,et al. Medullary thyroid cancer: management guidelines of the American Thyroid Association. , 2009, Thyroid : official journal of the American Thyroid Association.
[78] W. Linehan,et al. Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species , 2009, Molecular and Cellular Biology.
[79] L. Cantley,et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.
[80] W. Kaelin. Treatment of kidney cancer , 2009, Cancer.
[81] D. Connolly,et al. The role of the GPR91 ligand succinate in hematopoiesis , 2009, Journal of leukocyte biology.
[82] Greg Finak,et al. Regulation of endocytosis via the oxygen-sensing pathway , 2009, Nature Medicine.
[83] F. Galateau-Sallé,et al. PHD2 mutation and congenital erythrocytosis with paraganglioma. , 2008, The New England journal of medicine.
[84] Brian Keith,et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. , 2008, Cancer cell.
[85] C. Eng,et al. Age-related neoplastic risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germ line RET Cys634Trp (TGC>TGG) mutation. , 2008, Endocrine-related cancer.
[86] W. Kaelin. The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer , 2008, Nature Reviews Cancer.
[87] X. Mu,et al. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis , 2008, Nature Medicine.
[88] A. Ligon,et al. A germline mutation of the KIF1Bβ gene on 1p36 in a family with neural and nonneural tumors , 2008, Human Genetics.
[89] M. Meyerson,et al. The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. , 2008, Genes & development.
[90] S A Forbes,et al. The Catalogue of Somatic Mutations in Cancer (COSMIC) , 2008, Current protocols in human genetics.
[91] M. McMullin,et al. A gain-of-function mutation in the HIF2A gene in familial erythrocytosis. , 2008, The New England journal of medicine.
[92] C. Johannessen,et al. TORC1 Is Essential for NF1-Associated Malignancies , 2008, Current Biology.
[93] Chi V. Dang,et al. The interplay between MYC and HIF in cancer , 2008, Nature Reviews Cancer.
[94] R. Deberardinis,et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.
[95] Rosalie E Ferner. Neurofibromatosis 1 , 2010, European Journal of Human Genetics.
[96] R. Janknecht,et al. Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma , 2007 .
[97] N. Chandel,et al. Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis , 2007, Molecular and Cellular Biology.
[98] A. Tischler,et al. Pheochromocytomas in Nf1 knockout mice express a neural progenitor gene expression profile , 2007, Neuroscience.
[99] John D Gordan,et al. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. , 2007, Cancer cell.
[100] Charis Eng,et al. Cancer phenomics: RET and PTEN as illustrative models , 2007, Nature Reviews Cancer.
[101] G. Stamp,et al. Expression of HIF-1α, HIF-2α (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma with VHL and SDH Mutations , 2006 .
[102] J. Zondlo,et al. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[103] Douglas S. Richardson,et al. RET ligand-induced internalization and its consequences for downstream signaling , 2006, Oncogene.
[104] E. Gottlieb,et al. Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells. , 2006, Biochimica et biophysica acta.
[105] M. Gruber,et al. Hypoxia-inducible factors, hypoxia, and tumor angiogenesis , 2006, Current opinion in hematology.
[106] N. Denko,et al. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. , 2006, Cell metabolism.
[107] G. Semenza,et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. , 2006, Cell metabolism.
[108] R. Toledo,et al. Impact of RET proto-oncogene analysis on the clinical management of multiple endocrine neoplasia type 2. , 2006, Clinics.
[109] G. Stamp,et al. Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations. , 2006, The Journal of clinical endocrinology and metabolism.
[110] M. Pujana,et al. Novel pheochromocytoma susceptibility loci identified by integrative genomics. , 2005, Cancer research.
[111] W. Kaelin,et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. , 2005, Cancer cell.
[112] J R Griffiths,et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. , 2005, Human molecular genetics.
[113] Nancy D Perrier,et al. RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. , 2005, Thyroid : official journal of the American Thyroid Association.
[114] Patrick H. Maxwell,et al. Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma , 2005, Molecular and Cellular Biology.
[115] Sandro Santagata,et al. A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas , 2005, PLoS genetics.
[116] Yuen-Li Chung,et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. , 2005, Cancer cell.
[117] A. Harris,et al. HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia. , 2005, Experimental cell research.
[118] Okio Hino,et al. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. , 2005, Cancer research.
[119] Andrew L. Kung,et al. A HIF1-alpha Regulatory Loop Links Hypoxiaand Mitochondrial Signals in Pheochromocytomas , 2005 .
[120] David G. Watson,et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. , 2005, Cancer cell.
[121] Eyal Gottlieb,et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. , 2005, Cancer cell.
[122] W. Kaelin,et al. Role of VHL gene mutation in human cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[123] P. Munson,et al. Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome. , 2004, Endocrine-related cancer.
[124] J. Brugarolas,et al. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes. , 2004, Cancer cell.
[125] E. Jordanova,et al. Somatic loss of maternal chromosome 11 causes parent-of-origin-dependent inheritance in SDHD-linked paraganglioma and phaeochromocytoma families , 2004, Oncogene.
[126] Jinhai Gao,et al. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors , 2004, Nature.
[127] Yusuke Nakamura,et al. Germline mutations of the RET proto-oncogene in eight Japanese patients with multiple endocrine neoplasia type 2A (MEN2A) , 1995, Human Genetics.
[128] L. Aaltonen,et al. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. , 2004, American journal of human genetics.
[129] W. Kaelin,et al. Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth , 2003, PLoS biology.
[130] P. Rustin,et al. Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. , 2003, Cancer research.
[131] T. Jacks,et al. Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. , 2003, Genes & development.
[132] J. Strauchen. Germ-line mutations in nonsyndromic pheochromocytoma. , 2002, The New England journal of medicine.
[133] M. Ivan,et al. Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling , 2002, Science.
[134] Mirna Lechpammer,et al. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. , 2002, Cancer cell.
[135] A. Paetau,et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer , 2002, Nature Genetics.
[136] P. O’Farrell. Faculty Opinions recommendation of Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. , 2001 .
[137] G. Semenza,et al. HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus , 2001, Cell.
[138] E S Husebye,et al. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. , 2001, American journal of human genetics.
[139] P. Ratcliffe,et al. Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. , 2001, Human molecular genetics.
[140] M. Ivan,et al. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. , 2001, Human molecular genetics.
[141] M. Ivan,et al. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing , 2001, Science.
[142] Ulrich Müller,et al. Mutations in SDHC cause autosomal dominant paraganglioma, type 3 , 2000, Nature Genetics.
[143] G. Semenza. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. , 2000, Journal of applied physiology.
[144] A. Tischler,et al. C‐cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B , 2000, The EMBO journal.
[145] B. Devlin,et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. , 2000, Science.
[146] W. Kaelin,et al. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. , 1999, Science.
[147] R. Hammer,et al. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. , 1998, Genes & development.
[148] J. Louis,et al. GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF , 1996, Cell.
[149] B. Ponder,et al. Consequences of direct genetic testing for germline mutations in the clinical management of families with multiple endocrine neoplasia, type II. , 1995, JAMA.
[150] N. Asai,et al. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations , 1995, Molecular and cellular biology.
[151] al. et,et al. Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B , 1995, Science.
[152] A. Saltiel,et al. c-Myc Does Not Require Max for Transcriptional Activity in PC-12 Cells , 1994, Molecular and Cellular Neuroscience.
[153] Frank Costantini,et al. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret , 1994, Nature.
[154] B. Ponder,et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A , 1993, Nature.
[155] T. Sano,et al. ras Mutations in Endocrine Tumors: Mutation Detection by Polymerase Chain Reaction‐Single Strand Conformation Polymorphism , 1992, Japanese journal of cancer research : Gann.
[156] F. Collins,et al. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients , 1992, Nature.
[157] R. Eisenman,et al. Myc and Max associate in vivo. , 1992, Genes & development.
[158] M. Wigler,et al. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins , 1990, Cell.
[159] P. O'Connell,et al. Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus , 1990, Cell.
[160] A. Tischler,et al. Acute stimulation of chromaffin cell proliferation in the adult rat adrenal medulla. , 1988, Laboratory investigation; a journal of technical methods and pathology.
[161] H. Sather,et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. , 1985, The New England journal of medicine.
[162] C. Rigby,et al. Neurofibromatosis, phaeochromocytoma, and somatostatinoma. , 1982, British medical journal.
[163] D. Schadendorf,et al. Highly Recurrent TERT Promoter Mutations in Human Melanoma , 2022 .