Efficient Methyl Esterification Using Methoxyl Silica Gel as a Novel Dehydrating Reagent

Methoxyl silica gel was prepared readily by the treatment of silica chloride with methanol. By using methoxyl silica gel as a dehydrating agent, carboxylic acids reacted with methanol in the presence of a protonic acid such as 12-phosphotungstic acid afforded the corresponding methyl esters in excellent yields.

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