Whispering-Gallery Mode Resonators for Detecting Cancer

Optical resonators are sensors well known for their high sensitivity and fast response time. These sensors have a wide range of applications, including in the biomedical fields, and cancer detection is one such promising application. Sensor diagnosis currently has many limitations, such as being expensive, highly invasive, and time-consuming. New developments are welcomed to overcome these limitations. Optical resonators have high sensitivity, which enable medical testing to detect disease in the early stage. Herein, we describe the principle of whispering-gallery mode and ring optical resonators. We also add to the knowledge of cancer biomarker diagnosis, where we discuss the application of optical resonators for specific biomarkers. Lastly, we discuss advancements in optical resonators for detecting cancer in terms of their ability to detect small amounts of cancer biomarkers.

[1]  L.J. Guo,et al.  Polymer microring resonators for biochemical sensing applications , 2006, IEEE Journal of Selected Topics in Quantum Electronics.

[2]  Mani Hossein-Zadeh,et al.  Free ultra-high-Q microtoroid: a tool for designing photonic devices. , 2007, Optics express.

[3]  L. Maleki,et al.  Pigtailing the high-Q microsphere cavity: a simple fiber coupler for optical whispering-gallery modes. , 1999, Optics letters.

[4]  Ryan C Bailey,et al.  PCR-Free, Multiplexed Expression Profiling of microRNAs Using Silicon Photonic Microring Resonators. , 2016, Analytical chemistry.

[5]  Miguel Melo,et al.  Telomerase promoter mutations in cancer: an emerging molecular biomarker? , 2014, Virchows Archiv.

[6]  Kyungsup Han,et al.  Label-free, PCR-free chip-based detection of telomerase activity in bladder cancer cells. , 2013, Biosensors & bioelectronics.

[7]  Zachary S. Ballard,et al.  Stand-Off Biodetection with Free-Space Coupled Asymmetric Microsphere Cavities , 2015, Sensors.

[8]  John R. Crowther,et al.  The ELISA Guidebook , 2000, Methods in Molecular Biology™.

[9]  Avraham Rasooly Moving biosensors to point-of-care cancer diagnostics. , 2006, Biosensors & bioelectronics.

[10]  Kerry J. Vahala,et al.  Fabrication, Coupling and Nonlinear Optics of Ultra-High Micro-Sphere and Chip-Based Toroid Microcavities , 2004 .

[11]  G M Whitesides,et al.  A self-assembled monolayer for the binding and study of histidine-tagged proteins by surface plasmon resonance. , 1996, Analytical chemistry.

[12]  Valentina Donzella,et al.  Optical biosensors to analyze novel biomarkers in oncology , 2011, Journal of biophotonics.

[13]  E. Björklund,et al.  Analytical-scale microwave-assisted extraction. , 2000, Journal of chromatography. A.

[14]  Andrea M Armani,et al.  Silica microtoroid resonator sensor with monolithically integrated waveguides. , 2013, Optics express.

[15]  Stephen Holler,et al.  Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity. , 2013, Nano letters.

[16]  L. Pavesi,et al.  Sensitivity and Limit of detection of biosensors based on ring resonators , 2015, 2015 XVIII AISEM Annual Conference.

[17]  Yasha Yi,et al.  Hurricane: A simplified optical resonator for optical-power-based sensing with nano-particle taggants , 2010 .

[18]  A. Huston,et al.  Strain-sensitive elastic scattering from cylinders. , 1993, Optics letters.

[19]  K Vahala,et al.  Highly efficient optical power transfer to whispering-gallery modes by use of a symmetrical dual-coupling configuration. , 2000, Optics letters.

[20]  Robert C. Dunn,et al.  Whispering gallery mode imaging for the multiplexed detection of biomarkers , 2011 .

[21]  John E. Bowers,et al.  Integrated waveguide coupled Si_3N_4 resonators in the ultrahigh-Q regime , 2014 .

[22]  Yong-Jin Yoon,et al.  Rapid and label-free amplification and detection assay for genotyping of cancer biomarker. , 2015, Biosensors & bioelectronics.

[23]  Pablo Bianucci,et al.  Optical Microbottle Resonators for Sensing , 2016, Sensors.

[24]  L. C. Gunn,et al.  Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators. , 2009, Analytical chemistry.

[25]  L. Maleki,et al.  Optoelectronic microwave oscillator , 1996 .

[26]  R. Chang,et al.  Lasing Droplets: Highlighting the Liquid-Air Interface by Laser Emission , 1986, Science.

[27]  Carlo Edoardo Campanella,et al.  Label-free optical resonant sensors for biochemical applications , 2013 .

[28]  Jan Koch,et al.  A Microring Resonator Sensor for Sensitive Detection of 1,3,5-Trinitrotoluene (TNT) , 2010, Sensors.

[29]  Brent E. Little,et al.  Analytic theory of coupling from tapered fibers and half-blocks into microsphere resonators , 1999 .

[30]  P.-T. Ho,et al.  Higher order filter response in coupled microring resonators , 2000, IEEE Photonics Technology Letters.

[31]  S. Arnold,et al.  Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs. reactive mechanism. , 2010, Optics express.

[32]  Kent Lewandrowski,et al.  Point-of-care testing: an overview and a look to the future (circa 2009, United States). , 2009, Clinics in laboratory medicine.

[33]  R. Chang,et al.  Laser emission from individual droplets at wavelengths corresponding to morphology-dependent resonances. , 1984, Optics letters.

[34]  Thomas Ming-Hung Lee,et al.  Over-the-Counter Biosensors: Past, Present, and Future , 2008, Sensors.

[35]  Huidong Shi,et al.  Label-free DNA methylation analysis using opto-fluidic ring resonators. , 2010, Biosensors & bioelectronics.

[36]  Suejit Pechprasarn,et al.  Detection limits of confocal surface plasmon microscopy. , 2014, Biomedical optics express.

[37]  Chung-Yen Chao,et al.  Design and optimization of microring resonators in biochemical sensing applications , 2006, Journal of Lightwave Technology.

[38]  Gijsbertus J.M. Krijnen,et al.  Mechanical tuning of optical race-track ring resonators , 2010 .

[39]  Lan Yang,et al.  Single virus and nanoparticle size spectrometry by whispering-gallery-mode microcavities. , 2011, Optics express.

[40]  S. Arnold,et al.  Energy transfer and the photon lifetime within an aerosol particle. , 1989, Optics letters.

[41]  Berk Camli,et al.  A Microwave Ring Resonator Based Glucose Sensor , 2016 .

[42]  Hongying Zhu,et al.  Overview of novel integrated optical ring resonator bio/chemical sensors , 2007, SPIE LASE.

[43]  S. Arnold,et al.  Shift of whispering-gallery modes in microspheres by protein adsorption. , 2003, Optics letters.

[44]  Xinwan Li,et al.  Miniature Microring Resonator Sensor Based on a Hybrid Plasmonic Waveguide , 2011, Sensors.

[45]  A. Ashkin,et al.  Observation of optical resonances of dielectric spheres by light scattering. , 1981, Applied optics.

[46]  Anna Tesei,et al.  Specific Biomarkers Are Associated with Docetaxeland Gemcitabine-Resistant NSCLC Cell Lines. , 2012, Translational oncology.

[47]  W. L. Bond,et al.  Stimulated Emission into Optical Whispering Modes of Spheres , 1961 .

[48]  Ian M. White,et al.  An opto-fluidic ring resonator biosensor for the detection of organophosphorus pesticides , 2008 .

[49]  Tae Yoon Lee,et al.  A simple, low-cost, and rapid device for a DNA methylation-specific amplification/detection system using a flexible plastic and silicon complex. , 2014, Lab on a chip.

[50]  A. Matsko,et al.  Review of Applications of Whispering-Gallery Mode Resonators in Photonics and Nonlinear Optics , 2005 .

[51]  Guo-Qiang Lo,et al.  Label-free aptamer sensor based on silicon microring resonators , 2013 .

[52]  Hongying Zhu,et al.  Label-Free Optical Ring Resonator Bio/Chemical Sensors , 2010 .

[53]  Xu Xiaoqing,et al.  Progress on sample pretreatment techniques for polycyclic aromatic hydrocarbons in water system , 2011, 2011 International Conference on Electric Technology and Civil Engineering (ICETCE).

[54]  A. A. Savchenkov,et al.  Whispering-gallery mode based opto-electronic oscillators , 2010, 2010 IEEE International Frequency Control Symposium.

[55]  Judith Su,et al.  Label-Free Biological and Chemical Sensing Using Whispering Gallery Mode Optical Resonators: Past, Present, and Future , 2017, Sensors.

[56]  Hongying Zhu,et al.  Integrated refractive index optical ring resonator detector for capillary electrophoresis. , 2007, Analytical chemistry.

[57]  Abbas Madani,et al.  Design and fabrication of all-polymeric photonic waveguides in optical integrated circuits , 2017 .

[58]  Oliver Benson,et al.  Optimization of prism coupling to high-Q modes in a microsphere resonator using a near-field probe , 2005 .

[59]  Daniel R. Grischkowsky,et al.  Whispering-gallery-mode cavity for terahertz pulses , 2003 .

[60]  Francesco Baldini,et al.  Optical Microbubble Resonators with High Refractive Index Inner Coating for Bio-Sensing Applications: An Analytical Approach , 2016, Sensors.

[61]  Preeta Sharan,et al.  Photonic crystal ring resonator structure for temperature measurement , 2015 .

[62]  K. Koyama,et al.  Stimulated emission in a deformable fluorescent droplet , 2009, 2009 IEEE LEOS Annual Meeting Conference Proceedings.

[63]  R. Ulrich,et al.  Optimum Excitation of Optical Surface Waves , 1971 .

[64]  Mario Hauser,et al.  High-Q polymer resonators with spatially controlled photo-functionalization for biosensing applications , 2013 .

[65]  John Gohring,et al.  Detection of HER2 breast cancer biomarker using the opto-fluidic ring resonator biosensor , 2010 .

[66]  M. Gorodetsky,et al.  Ultimate Q of optical microsphere resonators. , 1996, Optics letters.

[67]  Rajan P Kulkarni,et al.  Label-Free, Single-Molecule Detection with Optical Microcavities , 2007, Science.

[68]  Frank Vollmer,et al.  Perturbation approach to resonance shift of whispering gallery modes in a dielectric microsphere as a probe of a surrounding medium , 2003 .

[69]  Joseph Wang,et al.  Electrochemical biosensors: towards point-of-care cancer diagnostics. , 2006, Biosensors & bioelectronics.

[70]  Catharine Wang,et al.  Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology , 2016, PLoS ONE.

[71]  Ai Qun Liu,et al.  Gas Sensor for Volatile Organic Compounds Detection Using Silicon Photonic Ring Resonator , 2016 .

[72]  M. K. Chin,et al.  Critical coupling, oscillation, reflection, and transmission in optical waveguide-ring resonator systems , 2006 .

[73]  Hongying Zhu,et al.  Rapid and label-free detection of breast cancer biomarker CA15-3 in clinical human serum samples with optofluidic ring resonator sensors. , 2009, Analytical chemistry.

[74]  Xudong Fan,et al.  Label Free Detection of CD4+ and CD8+ T Cells Using the Optofluidic Ring Resonator , 2010, Sensors.

[75]  Jian-Jun He,et al.  Label-free biosensing using cascaded double-microring resonators integrated with microfluidic channels , 2015 .

[76]  Laurent Bechou,et al.  Study of a polymer optical microring resonator for hexavalent chromium sensing , 2015 .

[77]  Heath A. Huckabay,et al.  Label-free detection of ovarian cancer biomarkers using whispering gallery mode imaging. , 2013, Biosensors & bioelectronics.

[78]  Xudong Fan,et al.  Universal coupling between metal-clad waveguides and optical ring resonators. , 2007, Optics express.

[79]  Robert W. Boyd,et al.  An environmental sensor based on an integrated optical whispering gallery mode disk resonator , 2007 .

[80]  Franco Cosi,et al.  Optical Microspherical Resonators for Biomedical Sensing , 2011, Sensors.

[81]  Ryan C Bailey,et al.  Biomolecular analysis with microring resonators: applications in multiplexed diagnostics and interaction screening. , 2013, Current opinion in chemical biology.

[82]  Yves-Alain Peter,et al.  Real-Time Detection of Staphylococcus Aureus Using Whispering Gallery Mode Optical Microdisks , 2016, Biosensors.

[83]  Pieter Dumon,et al.  Fundamental Principles of Operation and Notes on Fabrication of Photonic Microresonators , 2010 .

[84]  Keith D. Bartle,et al.  Supercritical fluid extraction , 2007 .

[85]  Huajian Gao,et al.  Ultrasonic technique for extracting nanofibers from nature materials , 2007 .

[86]  Tae Yoon Lee,et al.  LoMA-B: a simple and versatile lab-on-a-chip system based on single-channel bisulfite conversion for DNA methylation analysis. , 2015, Lab on a chip.

[87]  Hassan Ghafoorifard,et al.  An ultrasensitive optical label-free polymeric biosensor based on concentric triple microring resonators with a central microdisk resonator , 2016 .

[88]  B. Sheingold,et al.  The History of Healthcare Quality: The First 100 Years 1860-1960 , 2014 .

[89]  Jun Ye,et al.  Thermal noise in optical reference resonators , 2014, 2014 IEEE Metrology for Aerospace (MetroAeroSpace).

[90]  Juejun Hu,et al.  Design guidelines for optical resonator biochemical sensors , 2009 .

[91]  P. Debye,et al.  Der Lichtdruck auf Kugeln von beliebigem Material , 2014 .

[92]  Hongying Zhu,et al.  Phage-based label-free biomolecule detection in an opto-fluidic ring resonator. , 2008, Biosensors & bioelectronics.

[93]  Joseph Wang,et al.  Point-of-care biosensor systems for cancer diagnostics/prognostics. , 2006, Biosensors & bioelectronics.

[94]  Romeo Bernini,et al.  Optofluidic Approaches for Enhanced Microsensor Performances , 2014, Sensors.

[95]  A. Matsko,et al.  Optical resonators with whispering-gallery modes-part II: applications , 2006, IEEE Journal of Selected Topics in Quantum Electronics.

[96]  Jo-Shu Chang,et al.  Identification of anti-lung cancer extract from Chlorella vulgaris C-C by antioxidant property using supercritical carbon dioxide extraction , 2010 .

[97]  Gopalkrishna Hegde,et al.  Design and analysis of serially coupled double microring resonator based force sensor for 1 μN range measurement , 2017 .

[98]  R. Ghodssi,et al.  Integration of genetically modified virus-like-particles with an optical resonator for selective bio-detection , 2015, Nanotechnology.

[99]  I. Tothill Biosensors for cancer markers diagnosis. , 2009, Seminars in cell & developmental biology.

[100]  Judith Su,et al.  Label-Free Single Exosome Detection Using Frequency-Locked Microtoroid Optical Resonators , 2015 .

[101]  Yong Shin,et al.  Real-time, label-free isothermal solid-phase amplification/detection (ISAD) device for rapid detection of genetic alteration in cancers. , 2013, Lab on a chip.

[102]  J Wardle,et al.  Change in public awareness of symptoms and perceived barriers to seeing a doctor following Be Clear on Cancer campaigns in England , 2015, British Journal of Cancer.

[103]  Moving biosensors to point-of-care cancer diagnostics. Proceedings of a symposium. June 2005. , 2006, Biosensors & bioelectronics.

[104]  Romeo Bernini,et al.  Plasma functionalization procedure for antibody immobilization for SU-8 based sensor. , 2016, Biosensors & bioelectronics.

[105]  H. Horvath Gustav Mie and the scattering and absorption of light by particles: Historic developments and basics , 2009 .

[106]  Rob P. H. Kooyman,et al.  Improved detection method for evanescent wave interferometric chemical sensing , 1997 .

[107]  Muzammil Iqbal,et al.  Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[108]  Wei Pang,et al.  Performance and noise analysis of optical microresonator-based biochemical sensors using intensity detection. , 2016, Optics express.

[109]  Yong Shin,et al.  Label-free DNA sensor for detection of bladder cancer biomarkers in urine , 2013 .

[110]  Xudong Fan,et al.  Liquid-core optical ring-resonator sensors. , 2006, Optics letters.

[111]  Keyi Wang,et al.  Demonstration and characterization of distributed multiparticle-induced mode splitting in a microsphere resonator , 2016 .

[112]  Xu,et al.  Scattering-theory analysis of waveguide-resonator coupling , 2000, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[113]  J. E. Bowers,et al.  Integrated Si3N4/SiO2 ultra high Q ring resonators , 2012, IEEE Photonics Conference 2012.

[114]  Christopher A. Pohl,et al.  Accelerated Solvent Extraction: A Technique for Sample Preparation , 1996 .

[115]  Adam L. Washburn,et al.  Quantitative, label-free detection of five protein biomarkers using multiplexed arrays of silicon photonic microring resonators. , 2010, Analytical chemistry.

[116]  Corrections and clarifications. , 1994, Science.

[117]  Vladimir S. Ilchenko,et al.  Quality-factor and nonlinear properties of optical Whispering-Gallery modes , 1989 .

[118]  Jie Huang,et al.  Integrated Chemical Vapor Sensor Based on Thin Wall Capillary Coupled Porous Glass Microsphere Optical Resonator. , 2015, Sensors and actuators. B, Chemical.

[119]  Jian Bai,et al.  A temperature sensor based on optical microfiber knot resonator , 2009 .

[120]  S. Berneschi,et al.  High Q silica microbubble resonators fabricated by arc discharge. , 2011, Optics letters.

[121]  Yulin Deng,et al.  Giant enhancement in UV response of ZnO nanobelts by polymer surface-functionalization. , 2007, Journal of the American Chemical Society.

[122]  Brian M Stoltz,et al.  Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators , 2016, Light: Science & Applications.

[123]  Xudong Fan,et al.  Evanescent coupling between refillable ring resonators and laser-inscribed optical waveguides. , 2017, Applied optics.

[124]  Hongying Zhu,et al.  Label-free quantitative DNA detection using the liquid core optical ring resonator. , 2008, Biosensors & bioelectronics.

[125]  T. J. Kippenberg,et al.  Ultra-high-Q toroid microcavity on a chip , 2003, Nature.

[126]  Shaker A Mousa,et al.  Biosensors: the new wave in cancer diagnosis. , 2010, Nanotechnology, science and applications.

[127]  H. Haus,et al.  Microring resonator channel dropping filters , 1997 .

[128]  Vladimir S. Ilchenko,et al.  Optical microsphere resonators: optimal coupling to high-Q whispering-gallery modes , 1999 .

[129]  C. Raman,et al.  Whispering-Gallery Phenomena at St. Paul's Cathedral , 1921, Nature.