Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
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A. Kalgutkar | T. Maurer | J. Warmus | L. Buckbinder | C. Okerberg | D. Hepworth | Aaron C. Smith | Edward L. Conn | D. Kung | H. Eng | Daniel W. Widlicka | P. Bonin | Kay Ahn | A. Wolford | Tim F. Ryder | Raman K. Sharma | S. Bagley | R. Ruggeri | Gang Xing | K. Walters | Wenhua Jiao | S. T. Orr | P. Carpino | D. Fernando | M. Dowling | Yan Zhang | Samantha N Spath | Benjamin N. Rocke | D. Bowles | Y. Qi | Yanwei Zhang | S. T. M. Orr | Suvi T. M. Orr