Medical applications of surface-enhanced Raman scattering.

This perspective article provides an overview of selected medical applications of surface-enhanced Raman scattering (SERS), highlighting recent developments and trends. The use of SERS for detection, analysis and imaging has attracted great interest in the past decade owing to its high sensitivity and molecular fingerprint specificity. SERS can deliver chemical and structural information from analytes rapidly and nondestructively in a label-free manner. Alternatively, SERS labels or nanotags, when conjugated to target-specific ligands, can be employed for the selective detection and localization of the corresponding target molecule. Biomedical applications based on both approaches are highlighted.

[1]  Sebastian Schlücker,et al.  Label-free SERS monitoring of chemical reactions catalyzed by small gold nanoparticles using 3D plasmonic superstructures. , 2013, Journal of the American Chemical Society.

[2]  Luis M Liz-Marzán,et al.  SERS detection of small inorganic molecules and ions. , 2012, Angewandte Chemie.

[3]  Janina Kneipp,et al.  Nanomaterials in complex biological systems: insights from Raman spectroscopy. , 2012, Chemical Society reviews.

[4]  Jibin Song,et al.  Self-assembled plasmonic vesicles of SERS-encoded amphiphilic gold nanoparticles for cancer cell targeting and traceable intracellular drug delivery. , 2012, Journal of the American Chemical Society.

[5]  Janina Kneipp,et al.  Characterizing the kinetics of nanoparticle-catalyzed reactions by surface-enhanced Raman scattering. , 2012, Angewandte Chemie.

[6]  Duncan Graham,et al.  Detection of inflammation in vivo by surface-enhanced Raman scattering provides higher sensitivity than conventional fluorescence imaging. , 2012, Analytical chemistry.

[7]  Stefaan De Smedt,et al.  Cytotoxic effects of gold nanoparticles: a multiparametric study. , 2012, ACS nano.

[8]  Evanthia Papadopoulou,et al.  Label-free detection of nanomolar unmodified single- and double-stranded DNA by using surface-enhanced Raman spectroscopy on Ag and Au colloids. , 2012, Chemistry.

[9]  K. Carron,et al.  Lab-on-a-bubble surface enhanced Raman indirect immunoassay for cholera. , 2012, Analytical chemistry.

[10]  Nianqiang Wu,et al.  Detection of adenosine triphosphate with an aptamer biosensor based on surface-enhanced Raman scattering. , 2012, Analytical chemistry.

[11]  Mira Kim,et al.  Real-time monitoring of glutathione-triggered thiopurine anticancer drug release in live cells investigated by surface-enhanced Raman scattering. , 2012, Analytical chemistry.

[12]  Liguang Xu,et al.  Regiospecific plasmonic assemblies for in situ Raman spectroscopy in live cells. , 2012, Journal of the American Chemical Society.

[13]  Jonathan Weyhenmeyer,et al.  Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites. , 2012, Lab on a chip.

[14]  C. Brennan,et al.  A Brain Tumor Molecular Imaging Strategy Using A New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle , 2011, Nature Medicine.

[15]  Zijian Zhou,et al.  Nanoprobes for in vitro diagnostics of cancer and infectious diseases. , 2012, Biomaterials.

[16]  M. Haase,et al.  3D self-assembled plasmonic superstructures of gold nanospheres: synthesis and characterization at the single-particle level. , 2011, Small.

[17]  B. Panchapakesan,et al.  Gold nanoprobes for theranostics. , 2011, Nanomedicine.

[18]  Sebastian Schlücker,et al.  Synthesis of bifunctional Au/Pt/Au Core/shell nanoraspberries for in situ SERS monitoring of platinum-catalyzed reactions. , 2011, Journal of the American Chemical Society.

[19]  Richard P Van Duyne,et al.  In vivo, transcutaneous glucose sensing using surface-enhanced spatially offset Raman spectroscopy: multiple rats, improved hypoglycemic accuracy, low incident power, and continuous monitoring for greater than 17 days. , 2011, Analytical chemistry.

[20]  S. Schlücker,et al.  Gold Nanoparticles: Fast and Cost‐Effective Purification of Gold Nanoparticles in the 20–250 nm Size Range by Continuous Density Gradient Centrifugation (Small 17/2011) , 2011 .

[21]  S. Schlücker,et al.  Fast and cost-effective purification of gold nanoparticles in the 20-250 nm size range by continuous density gradient centrifugation. , 2011, Small.

[22]  Duncan Graham,et al.  Separation free DNA detection using surface enhanced Raman scattering. , 2011, Analytical chemistry.

[23]  Evanthia Papadopoulou,et al.  Label-Free Detection of Single-Base Mismatches in DNA by Surface-Enhanced Raman Spectroscopy , 2011, Angewandte Chemie.

[24]  Jian Dong,et al.  Minimally invasive surface-enhanced Raman scattering detection with depth profiles based on a surface-enhanced Raman scattering-active acupuncture needle. , 2011, Analytical chemistry.

[25]  Wen Ren,et al.  A binary functional substrate for enrichment and ultrasensitive SERS spectroscopic detection of folic acid using graphene oxide/Ag nanoparticle hybrids. , 2011, ACS nano.

[26]  Malini Olivo,et al.  Ultrasensitive near-infrared Raman reporters for SERS-based in vivo cancer detection. , 2011, Angewandte Chemie.

[27]  Marc D Porter,et al.  Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering. , 2011, Analytical chemistry.

[28]  Sebastian Schlücker,et al.  Hydrophilically stabilized gold nanostars as SERS labels for tissue imaging of the tumor suppressor p63 by immuno-SERS microscopy. , 2011, Chemical communications.

[29]  G. Lloyd,et al.  Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging – the next dimension , 2011 .

[30]  A. Moore,et al.  Noninvasive MRI-SERS imaging in living mice using an innately bimodal nanomaterial. , 2011, ACS nano.

[31]  Joseph Irudayaraj,et al.  DNA-gold nanoparticle reversible networks grown on cell surface marker sites: application in diagnostics. , 2011, ACS nano.

[32]  Patrick A Johnson,et al.  Surface-enhanced Raman scattering detection of DNA derived from the west nile virus genome using magnetic capture of Raman-active gold nanoparticles. , 2011, Analytical chemistry.

[33]  Sadia Afrin Khan,et al.  Gold nano-popcorn-based targeted diagnosis, nanotherapy treatment, and in situ monitoring of photothermal therapy response of prostate cancer cells using surface-enhanced Raman spectroscopy. , 2010, Journal of the American Chemical Society.

[34]  G. Shaw,et al.  Folic acid in early pregnancy: a public health success story , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  A. Jemal,et al.  Cancer Statistics, 2010 , 2010, CA: a cancer journal for clinicians.

[36]  Jaebum Choo,et al.  Optoelectrofluidic sandwich immunoassays for detection of human tumor marker using surface-enhanced Raman scattering. , 2010, Analytical chemistry.

[37]  Duncan Graham,et al.  Prospects of deep Raman spectroscopy for noninvasive detection of conjugated surface enhanced resonance Raman scattering nanoparticles buried within 25 mm of mammalian tissue. , 2010, Analytical chemistry.

[38]  Sang Yup Lee,et al.  Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor. , 2010, Nano letters.

[39]  Reinhard Niessner,et al.  Surface-enhanced Raman scattering-based label-free microarray readout for the detection of microorganisms. , 2010, Analytical chemistry.

[40]  Hongyu Chen,et al.  Measuring ensemble-averaged surface-enhanced Raman scattering in the hotspots of colloidal nanoparticle dimers and trimers. , 2010, Journal of the American Chemical Society.

[41]  K. Faulds,et al.  Surface-enhanced Raman scattering as a detection technique for molecular diagnostics , 2009, Expert review of molecular diagnostics.

[42]  S. Bell,et al.  SERS enhancement by aggregated Au colloids: effect of particle size. , 2009, Physical chemistry chemical physics : PCCP.

[43]  Sebastian Schlücker,et al.  SERS microscopy: nanoparticle probes and biomedical applications. , 2009, Chemphyschem : a European journal of chemical physics and physical chemistry.

[44]  Elodie Boisselier,et al.  Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. , 2009, Chemical Society reviews.

[45]  Yukihiro Ozaki,et al.  Label-free highly sensitive detection of proteins in aqueous solutions using surface-enhanced Raman scattering. , 2009, Analytical chemistry.

[46]  Y. Ozaki,et al.  Surface-enhanced Raman scattering for protein detection , 2009, Analytical and bioanalytical chemistry.

[47]  Li Wang,et al.  Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering. , 2009, Bioconjugate chemistry.

[48]  Alexander Marx,et al.  SERS labels for red laser excitation: silica-encapsulated SAMs on tunable gold/silver nanoshells. , 2009, Angewandte Chemie.

[49]  Yoon-Sik Lee,et al.  Multiplex immunoassay using fluorescent-surface enhanced Raman spectroscopic dots for the detection of bronchioalveolar stem cells in murine lung. , 2009, Analytical Chemistry.

[50]  C. Domingo,et al.  Sensing polycyclic aromatic hydrocarbons with dithiocarbamate-functionalized ag nanoparticles by surface-enhanced Raman scattering. , 2009, Analytical chemistry.

[51]  Luis M Liz-Marzán,et al.  Au@pNIPAM colloids as molecular traps for surface-enhanced, spectroscopic, ultra-sensitive analysis. , 2009, Angewandte Chemie.

[52]  Naomi J Halas,et al.  Observing metal-catalyzed chemical reactions in situ using surface-enhanced Raman spectroscopy on Pd-Au nanoshells. , 2008, Journal of the American Chemical Society.

[53]  M. Natan,et al.  Surface-enhanced Raman scattering tags for rapid and homogeneous detection of circulating tumor cells in the presence of human whole blood. , 2008, Journal of the American Chemical Society.

[54]  P. Bartlett,et al.  SERS-melting: a new method for discriminating mutations in DNA sequences. , 2008, Journal of the American Chemical Society.

[55]  N. Shah,et al.  Surface-enhanced Raman spectroscopy. , 2008, Annual review of analytical chemistry.

[56]  K. Kneipp,et al.  SERS--a single-molecule and nanoscale tool for bioanalytics. , 2008, Chemical Society reviews.

[57]  J. Ingwall,et al.  How does folic acid cure heart attacks? , 2008, Circulation.

[58]  N. Halas,et al.  Surface-enhanced Raman spectroscopy of DNA. , 2008, Journal of the American Chemical Society.

[59]  Sabine Neuss,et al.  Size-dependent cytotoxicity of gold nanoparticles. , 2007, Small.

[60]  H. Scher,et al.  Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer , 2007, Clinical Cancer Research.

[61]  Harikrishna Nakshatri,et al.  CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis , 2006, Breast Cancer Research.

[62]  D. A. Stuart,et al.  In vivo glucose measurement by surface-enhanced Raman spectroscopy. , 2006, Analytical chemistry.

[63]  Alexander Marx,et al.  Immuno‐Raman microspectroscopy: In situ detection of antigens in tissue specimens by surface‐enhanced Raman scattering , 2006 .

[64]  Olga Lyandres,et al.  Real-time glucose sensing by surface-enhanced Raman spectroscopy in bovine plasma facilitated by a mixed decanethiol/mercaptohexanol partition layer. , 2005, Analytical chemistry.

[65]  M. Porter,et al.  Low-level detection of viral pathogens by a surface-enhanced Raman scattering based immunoassay. , 2005, Analytical chemistry.

[66]  C. Murphy,et al.  Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. , 2005, Small.

[67]  C. Domingo,et al.  Study of the Interaction of Pollutant Nitro Polycyclic Aromatic Hydrocarbons with Different Metallic Surfaces by Surface-Enhanced Vibrational Spectroscopy (SERS and SEIR) , 2003 .

[68]  Thomas Laurell,et al.  On-line monitoring of airborne chemistry in levitated nanodroplets: in situ synthesis and application of SERS-active Ag-Sols for trace analysis by FT-Raman spectroscopy. , 2003, Analytical chemistry.

[69]  R. V. Van Duyne,et al.  Toward a glucose biosensor based on surface-enhanced Raman scattering. , 2003, Journal of the American Chemical Society.

[70]  C. Mirkin,et al.  Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. , 2002, Science.

[71]  Michael S. Feld,et al.  Surface-Enhanced Raman Spectroscopy in Single Living Cells Using Gold Nanoparticles , 2002 .

[72]  H. Friess,et al.  Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[73]  R. Dasari,et al.  Surface-enhanced Raman scattering and biophysics , 2001 .

[74]  D. Hammer,et al.  Polymersomes: tough vesicles made from diblock copolymers. , 1999, Science.

[75]  Andreas Otto,et al.  Surface-Enhanced Raman Scattering of Adsorbates , 1991 .

[76]  Leonida Georgescu,et al.  VIRUSES IN ENDEMIC (BALKAN) NEPHROPATHY , 1976, The Lancet.

[77]  E. Reynolds.  Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients. , 1967, Lancet.