论文信息 - Reduced serum antioxidant capacity in healthy centenarians.

Reduced serum antioxidant capacity in healthy centenarians.

Free radicals are considered important factors in biological aging (1). Consequently, there is increasing interest in the mechanisms of antioxidant protection against free-radical-induced injury and in identification of suitable biochemical indicators for measuring serum antioxidant capacity (SAC) (2). Several methods have been proposed for the measurement of SAC, including the enhanced chemiluminescence assay used in this study (3). This technique is calibrated with Trolox™, a water-soluble vitamin E analog (Hoffmann–La Roche, obtained from Aldrich Chemical Co., Gillingham, Dorset, UK), and assay results are expressed as μmol/L Trolox equivalents. We measured serum SAC in 58 healthy subjects: 37 adults (19 men and 18 women, age range 18–91 years) and 21 centenarians …

[1] J. Gutteridge,et al. Lipid peroxidation and antioxidants as biomarkers of tissue damage. , 1995, Clinical chemistry.

[2] C. Loughrey,et al. Effect of hemodialysis on total antioxidant capacity and serum antioxidants in patients with chronic renal failure. , 1995, Clinical chemistry.

[3] B. Ames,et al. Oxidants, antioxidants, and the degenerative diseases of aging. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[4] S. Maxwell,et al. Enhanced chemiluminescent assay for antioxidant capacity in biological fluids , 1992 .

[5] T. Whitehead,et al. Serum Urate, Serum Glucose and Diabetes , 1992, Annals of clinical biochemistry.

[6] D. Knook,et al. Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the senieur protocol , 1990, Mechanisms of Ageing and Development.

[7] K. Ingold,et al. The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma. , 1987, Biochimica et biophysica acta.

[8] H. Müller-Hermelink,et al. Admission criteria for immunogerontological studies in man: The senieur protocol , 1984, Mechanisms of Ageing and Development.