Homeostasis of naive and memory T cells.

[1]  Rustom Antia,et al.  Memory CD8 T-cell compartment grows in size with immunological experience , 2009, Nature.

[2]  L. Lefrançois,et al.  Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. , 2008, Immunity.

[3]  J. Sprent,et al.  The Lymphopenic Environment of CD132 (Common γ-Chain)-Deficient Hosts Elicits Rapid Homeostatic Proliferation of Naive T Cells via IL-151 , 2008, The Journal of Immunology.

[4]  Michael J Bevan,et al.  Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. , 2008, Immunity.

[5]  D. Green,et al.  How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? , 2008, Trends in cell biology.

[6]  A. Rolink,et al.  Regulation of T cell survival through coronin-1–mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering , 2008, Nature Immunology.

[7]  M. Fei,et al.  IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia , 2008, Nature Medicine.

[8]  S. Sa,et al.  Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.

[9]  E. Sebzda,et al.  Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns , 2008, Nature Immunology.

[10]  B. Schraven,et al.  Regulation of T Cell Homeostasis by the Transmembrane Adaptor Protein SIT1 , 2008, The Journal of Immunology.

[11]  John T. Harty,et al.  Shaping and reshaping CD8+ T-cell memory , 2008, Nature Reviews Immunology.

[12]  C. Louis-dit-Sully,et al.  The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. , 2008, Immunity.

[13]  T. Malek,et al.  Non‐redundant role for IL‐7R signaling for the survival of CD8+ memory T cells , 2007, European journal of immunology.

[14]  Xing Wang Deng,et al.  COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor–induced entry into the cell cycle from quiescence , 2007, Nature Immunology.

[15]  B. Hinz,et al.  Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells , 2007, Nature Immunology.

[16]  Marion Pepper,et al.  Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. , 2007, Immunity.

[17]  J. Sprent,et al.  An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2 , 2007, The Journal of experimental medicine.

[18]  Mark M Davis,et al.  A role for "self" in T-cell activation. , 2007, Seminars in immunology.

[19]  F. Finkelman,et al.  Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis , 2007, The Journal of experimental medicine.

[20]  Masato Kubo,et al.  SOCS proteins, cytokine signalling and immune regulation , 2007, Nature Reviews Immunology.

[21]  N. Reiling,et al.  Soluble Interleukin (IL)-15Rα Is Generated by Alternative Splicing or Proteolytic Cleavage and Forms Functional Complexes with IL-15* , 2007, Journal of Biological Chemistry.

[22]  J. Sprent,et al.  Antiviral CD4+ memory T cells are IL-15 dependent , 2007, The Journal of experimental medicine.

[23]  E. Wherry,et al.  Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection , 2007, The Journal of experimental medicine.

[24]  Mark M. Davis,et al.  miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection , 2007, Cell.

[25]  M. Goldsmith,et al.  Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice , 2007, The Journal of experimental medicine.

[26]  R. Mazzucchelli,et al.  Interleukin-7 receptor expression: intelligent design , 2007, Nature Reviews Immunology.

[27]  O. Boyman,et al.  B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation , 2007, Nature Immunology.

[28]  You-Wen He,et al.  A critical role for the autophagy gene Atg5 in T cell survival and proliferation , 2007, The Journal of experimental medicine.

[29]  M. Tolaini,et al.  Do CD8 effector cells need IL-7R expression to become resting memory cells? , 2006, Blood.

[30]  D. Danilenko,et al.  Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis , 2006, Science.

[31]  F. Powrie,et al.  Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation , 2006, Immunological reviews.

[32]  Corey M. Carlson,et al.  Kruppel-like factor 2 regulates thymocyte and T-cell migration , 2006, Nature.

[33]  Xing Chang,et al.  Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts , 2006, The Journal of experimental medicine.

[34]  J. Sprent,et al.  A major histocompatibility complex class I–dependent subset of memory phenotype CD8+ cells , 2006, The Journal of experimental medicine.

[35]  P. Marrack,et al.  Not all CD4+ memory T cells are long lived , 2006, Immunological reviews.

[36]  S. Jameson,et al.  The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells , 2006, Nature Immunology.

[37]  A. Khoruts,et al.  Naïve and Memory CD4+ T Cell Survival Controlled by Clonal Abundance , 2006, Science.

[38]  R. Rottapel,et al.  Suppressor of Cytokine Signaling 1 Stringently Regulates Distinct Functions of IL-7 and IL-15 In Vivo during T Lymphocyte Development and Homeostasis1 , 2006, The Journal of Immunology.

[39]  J. Sprent,et al.  Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes , 2006, Science.

[40]  P. Burkett,et al.  Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. , 2006, Annual review of immunology.

[41]  L. Hennighausen,et al.  Stat5a/b are essential for normal lymphoid development and differentiation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[42]  E. Wherry,et al.  Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin , 2005, Nature Immunology.

[43]  W. Alexander,et al.  SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential , 2005, The Journal of experimental medicine.

[44]  J. Sprent,et al.  Regulation of mature T cell homeostasis. , 2005, Seminars in immunology.

[45]  R. Deberardinis,et al.  Autophagy in metazoans: cell survival in the land of plenty , 2005, Nature Reviews Molecular Cell Biology.

[46]  W. Paul,et al.  Spontaneous and Homeostatic Proliferation of CD4 T Cells Are Regulated by Different Mechanisms , 2005, The Journal of Immunology.

[47]  A. Troy,et al.  Cutting Edge: Recent Immune Status Determines the Source of Antigens That Drive Homeostatic T Cell Expansion1 , 2005, The Journal of Immunology.

[48]  Stephen P. Schoenberger,et al.  CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death , 2005, Nature.

[49]  D. Vignali,et al.  Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)1 , 2005, The Journal of Immunology.

[50]  Yili Yang,et al.  Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. , 2004, Blood.

[51]  Michelle M. Sandau,et al.  Cutting Edge: Transpresentation of IL-15 by Bone Marrow-Derived Cells Necessitates Expression of IL-15 and IL-15Rα by the Same Cells1 , 2004, The Journal of Immunology.

[52]  Richard Park,et al.  The molecular program induced in T cells undergoing homeostatic proliferation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[53]  T. Hirano,et al.  Evidence of a Novel IL-2/15Rβ-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells1 , 2004, The Journal of Immunology.

[54]  Yang Liu,et al.  CD24 Expression on T Cells Is Required for Optimal T Cell Proliferation in Lymphopenic Host , 2004, The Journal of experimental medicine.

[55]  P. Burkett,et al.  Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis , 2004, The Journal of experimental medicine.

[56]  A. Khoruts,et al.  A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells1 , 2004, The Journal of Immunology.

[57]  M. Bevan,et al.  CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection , 2004, Nature Immunology.

[58]  M. Bevan.  Helping the CD8+ T-cell response , 2004, Nature Reviews Immunology.

[59]  A. Singer,et al.  Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. , 2004, Immunity.

[60]  H. Young,et al.  Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members , 2004, Molecular and Cellular Biology.

[61]  J. Sprent,et al.  IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[62]  B. Bienvenu,et al.  Suppression of CD4+ T Lymphocyte Effector Functions by CD4+CD25+ Cells In Vivo1 , 2004, The Journal of Immunology.

[63]  R. Welsh,et al.  Plasticity of T Cell Memory Responses to Viruses , 2004, Immunity.

[64]  C. Surh,et al.  A Role for TCR Affinity in Regulating Naive T Cell Homeostasis 1 , 2004, The Journal of Immunology.

[65]  S. Swain,et al.  IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells , 2003, The Journal of experimental medicine.

[66]  L. Bradley,et al.  Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells , 2003, The Journal of experimental medicine.

[67]  S. Korsmeyer,et al.  Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 , 2003, Nature.

[68]  Timothy K Starr,et al.  Positive and negative selection of T cells. , 2003, Annual review of immunology.

[69]  J. Sprent,et al.  T cell memory. , 2003, Annual review of immunology.

[70]  O. Lantz,et al.  Are Major Histocompatibility Complex Molecules Involved in the Survival of Naive CD4+ T Cells? , 2003, The Journal of experimental medicine.

[71]  Benedict Seddon,et al.  Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells , 2003, Nature Immunology.

[72]  D. Tough,et al.  IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells1 , 2003, The Journal of Immunology.

[73]  Bruno Martin,et al.  On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[74]  B. Stockinger,et al.  Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells , 2003, The Journal of experimental medicine.

[75]  F. Powrie,et al.  Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells1 , 2003, The Journal of Immunology.

[76]  E. Stanley,et al.  Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. , 2003, Immunity.

[77]  P. Burkett,et al.  IL-15Rα expression on CD8+ T cells is dispensable for T cell memory , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[78]  Rustom Antia,et al.  Lineage relationship and protective immunity of memory CD8 T cell subsets , 2003, Nature Immunology.

[79]  A. Khoruts,et al.  Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[80]  A. Khaled,et al.  Lymphocide: cytokines and the control of lymphoid homeostasis , 2002, Nature Reviews Immunology.

[81]  T. Waldmann,et al.  IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells , 2002 .

[82]  J. Sprent,et al.  Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells , 2002, The Journal of experimental medicine.

[83]  R. Zamoyska,et al.  TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells1 , 2002, The Journal of Immunology.

[84]  W. Leonard,et al.  IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[85]  R. Zamoyska,et al.  TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells1 , 2002, The Journal of Immunology.

[86]  Stephen C. Jameson,et al.  Maintaining the norm: T-cell homeostasis , 2002, Nature Reviews Immunology.

[87]  E. Wherry,et al.  Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells , 2002, The Journal of experimental medicine.

[88]  C. Benoist,et al.  Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells , 2002, The Journal of experimental medicine.

[89]  J. Sprent,et al.  Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells , 2002, The Journal of experimental medicine.

[90]  J. Sprent,et al.  Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells , 2002, The Journal of experimental medicine.

[91]  Rustom Antia,et al.  Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells , 2002, The Journal of experimental medicine.

[92]  B. Stockinger,et al.  Impairment of immunological memory in the absence of MHC despite survival of memory T cells , 2002, Nature Immunology.

[93]  Z. Dai,et al.  Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool1 , 2001, The Journal of Immunology.

[94]  W. Leonard.  Cytokines and immunodeficiency diseases , 2001, Nature Reviews Immunology.

[95]  A. Khoruts,et al.  Homeostatic Expansion Occurs Independently of Costimulatory Signals1 , 2001, The Journal of Immunology.

[96]  A. Strasser,et al.  Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. , 2001, Developmental cell.

[97]  P. Burkett,et al.  T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation , 2001, The Journal of experimental medicine.

[98]  T. Fry,et al.  Interleukin-7: master regulator of peripheral T-cell homeostasis? , 2001, Trends in immunology.

[99]  J. Lieberman,et al.  Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. , 2001, The Journal of clinical investigation.

[100]  Dirk Homann,et al.  Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory , 2001, Nature Medicine.

[101]  K. Rajewsky,et al.  How αβ T cells deal with induced TCRα ablation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[102]  Richard Murray,et al.  IL-7 is critical for homeostatic proliferation and survival of naïve T cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[103]  C Benoist,et al.  How much TCR does a T cell need? , 2001, Immunity.

[104]  M. Caligiuri,et al.  Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8+ T Cells , 2001, The Journal of experimental medicine.

[105]  S. Jameson,et al.  Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo , 2000, Nature Immunology.

[106]  R. Germain,et al.  CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling , 2000, Nature Immunology.

[107]  O. Lantz,et al.  γ chain required for naïve CD4+ T cell survival but not for antigen proliferation , 2000, Nature Immunology.

[108]  P. Morrissey,et al.  Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice , 2000, The Journal of experimental medicine.

[109]  S. Swain,et al.  Class II-independent generation of CD4 memory T cells from effectors. , 1999, Science.

[110]  J. Platt,et al.  Regulation of T cell homeostasis by heparan sulfate-bound IL-2. , 1999, Journal of immunology.

[111]  J. Sprent,et al.  The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. , 1999, Immunity.

[112]  M. Bevan,et al.  Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. , 1999, Immunity.

[113]  James M. Roberts,et al.  CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.

[114]  C. Janeway,et al.  Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. , 1999, Immunity.

[115]  W. Leonard,et al.  Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity , 1998, The Journal of experimental medicine.

[116]  T. Dassopoulos,et al.  IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. , 1998, Immunity.

[117]  Michael P. Brown,et al.  Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.

[118]  J. Sprent,et al.  Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. , 1998, Immunity.

[119]  M. Bevan,et al.  Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. , 1998, Immunity.

[120]  C. Mackall,et al.  Restoration of T-cell homeostasis after T-cell depletion. , 1997, Seminars in immunology.

[121]  W. Leonard,et al.  An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. , 1997, Immunity.

[122]  J. Leiden,et al.  LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. , 1997, Science.

[123]  F. Lemonnier,et al.  Differential requirements for survival and proliferation of CD8 naïve or memory T cells. , 1997, Science.

[124]  J. Sprent,et al.  T Cell Stimulation In Vivo by Lipopolysaccharide (LPS) , 1997, The Journal of experimental medicine.

[125]  H. Arakawa,et al.  MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. , 1996, Immunity.

[126]  J. Sprent,et al.  Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo , 1996, Science.

[127]  K. Rajewsky,et al.  A role for CD5 in TCR-mediated signal transduction and thymocyte selection. , 1995, Science.

[128]  S. Burdach,et al.  Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine , 1995, The Journal of experimental medicine.

[129]  J. Sprent,et al.  Turnover of naive- and memory-phenotype T cells , 1994, The Journal of experimental medicine.

[130]  S. Korsmeyer,et al.  Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair , 1993, Cell.

[131]  A. Kruisbeek,et al.  Mice deprived of exogenous antigenic stimulation develop a normal repertoire of functional T cells. , 1992, Journal of immunology.

[132]  W. Paul,et al.  Neonates support lymphopenia-induced proliferation. , 2003, Immunity.

[133]  C. Surh,et al.  Homeostasis Within the T Cell Compartment Autologous Regulation of Naive T Cell , 2001 .

[134]  A. Coutinho,et al.  Autonomous activation of B and T cells in antigen‐free mice , 1986, European journal of immunology.