Cucurbita Plants: From Farm to Industry

The Cucurbita genus, a member of Cucurbitaceae family, also known as cucurbits, is native to the Americas. Genus members, like Cucurbita pepo and Cucurbita maxima, have been used for centuries in folk medicine for treating gastrointestinal diseases and intestinal parasites. These pharmacological effects are mainly attributed to their phytochemical composition. Indeed, Cucurbita species are a natural source of carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, functional carbohydrates, and polysaccharides, that beyond exerting remarkable biological effects, have also been increasingly exploited for biotechnological applications. In this article, we specifically cover the habitat, cultivation, phytochemical composition, and food preservative abilities of Cucurbita plants.

[1]  F. V. Rand,et al.  Transmission and Control of Bacterial Wilt of Cucurbits. , 1916 .

[2]  S. Rehm,et al.  Bitter principles of the cucurbitaceae. VII.†—the distribution of bitter principles in this plant family , 1957 .

[3]  S. Rehm,et al.  Bitter principles of the cucurbitaceae. VIII.—cucurbitacins in seedlings—occurrence, biochemistry and genetical aspects , 1957 .

[4]  Chemical studies on Cucurbita moschata Duch. I. The isolation and structural studies of cucurbitine, a new amino acid. , 1961, Scientia Sinica.

[5]  Z. Paryzek Tetracyclic triterpenes. Part 2. A synthetic approach to cucurbitacins , 1979 .

[6]  A. M. Rhodes,et al.  Cucurbitacin Contents and Diabroticite (Coleoptera: Chrysomelidae) Feeding upon Cucurbita spp. , 1982 .

[7]  D. A. Smith,et al.  Squash Containing Toxic Cucurbitacin Compounds Occurring in California and Alabama. , 1984, Journal of food protection.

[8]  Terrence F. Hutt,et al.  The determination of bitter principles in zucchinis , 1985 .

[9]  G. Stoewsand,et al.  Toxicologic Response in Mice Fed Cucurbita Fruit. , 1985, Journal of food protection.

[10]  J. Buwalda,et al.  Hybrid squash: Responses to nitrogen, potassium, and phosphorus fertilisers on a soil of moderate fertility , 1986 .

[11]  T. Hidaka,et al.  THE COMPOSITION AND VITAMIN A VALUE OF THE CAROTENOIDS OF PUMPKINS OF DIFFERENT COLORS , 1987 .

[12]  R. Metcalf,et al.  Dry Cucurbitacin-containing Baits for Controlling Diabroticite Beetles (Coleoptera: Chrysomelidae) , 1987 .

[13]  M. Dubois,et al.  Foetidissimoside A, a new 3,28-bidesmosidic triterpenoid saponin, and cucurbitacins from Cucurbita foetidissima , 1988 .

[14]  P. Molnar,et al.  [Main carotenoids in pressed seeds (Cucurbitae semen) of oil pumpkin (Cucurbita pepo convar. pepo var. styriaca)]. , 1993, Acta pharmaceutica Hungarica.

[15]  H. Paris,et al.  Variability in the reaction of squash (Cucurbita pepo) to inoculation with Sphaerotheca fuliginea and methodology of breeding for resistance , 1993 .

[16]  S. K. Sipp,et al.  Pumpkin Growth, Flowering, and Fruiting Response to Nitrogen and Potassium Sprinkler Fertigation in Sandy Soil , 1994 .

[17]  M. Murkovic,et al.  Variability of fatty acid content in pumpkin seeds (Cucurbita pepo L.) , 1996, Zeitschrift fur Lebensmittel-Untersuchung und -Forschung.

[18]  N. Cheong,et al.  Purification and characterization of an antifungal PR-5 protein from pumpkin leaves. , 1997, Molecules and cells.

[19]  S. Reiners,et al.  Plant Spacing and Variety Affect Pumpkin Yield and Fruit Size, but Supplemental Nitrogen Does Not , 1997 .

[20]  Bruce D. Smith The Initial Domestication of Cucurbita pepo in the Americas 10,000 Years Ago , 1997 .

[21]  R. Bauer,et al.  A new major triterpene saponin from the roots of Cucurbita foetidissima. , 2000, Journal of natural products.

[22]  Y. Younis,et al.  African Cucurbita pepo L.: properties of seed and variability in fatty acid composition of seed oil. , 2000, Phytochemistry.

[23]  E. González,et al.  Carotenoid composition and vitamin A value of an Argentinian squash (Cucurbita moschata). , 2001, Archivos latinoamericanos de nutricion.

[24]  B. D. Smith,et al.  Documenting plant domestication: the consilience of biological and archaeological approaches. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[25]  K. H. Miean,et al.  Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. , 2001, Journal of agricultural and food chemistry.

[26]  D. Bisognin Origin and evolution of cultivated cucurbits , 2002 .

[27]  M. Murkovic,et al.  Carotenoid Content in Different Varieties of Pumpkins , 2002 .

[28]  Dolores R. Piperno,et al.  Phylogenetic relationships among domesticated and wild species of Cucurbita (Cucurbitaceae) inferred from a mitochondrial gene: Implications for crop plant evolution and areas of origin , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  J. McCreight,et al.  Breeding cucurbit crops for powdery mildew resistance. , 2002 .

[30]  B. Jayaprakasam,et al.  Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. , 2003, Cancer letters.

[31]  F. Halaweish,et al.  A new cucurbitacin profile forCucurbita andreana: A candidate for cucurbitacin tissue culture , 1993, Journal of Chemical Ecology.

[32]  I. Amoo,et al.  Characterisation of oil extracted from gourd (Cucurbita maxima) seed , 2004 .

[33]  M. Babadoost Phytophthora blight of cucurbits , 2005 .

[34]  Wei Li,et al.  Cucurbitosides F-M, acylated phenolic glycosides from the seeds of Cucurbita pepo. , 2005, Journal of natural products.

[35]  Jian Chao Chen,et al.  Cucurbitacins and cucurbitane glycosides: structures and biological activities. , 2005, Natural product reports.

[36]  L. Polito,et al.  Ribosome-inactivating proteins in edible plants and purification and characterization of a new ribosome-inactivating protein from Cucurbita moschata. , 2006, Biochimica et biophysica acta.

[37]  Tao Xia,et al.  D‐chiro‐Inositol found in Cucurbita ficifolia (Cucurbitaceae) fruit extracts plays the hypoglycaemic role in streptozocin‐diabetic rats , 2006, The Journal of pharmacy and pharmacology.

[38]  S. Jossey,et al.  First Report of Tobacco ringspot virus in Pumpkin (Cucurbita pepo) in Illinois. , 2006, Plant disease.

[39]  S. Nakić,et al.  Chemical characteristics of oils from naked and husk seeds of Cucurbita pepo L. , 2006 .

[40]  L. Tarhan,et al.  In Vitro Antioxidant Properties of Cucurbita Pepo L. Male and Female Flowers Extracts , 2007, Plant foods for human nutrition.

[41]  You Lv,et al.  Chemical composition and antioxidant activity of an acidic polysaccharide extracted from Cucurbita moschata Duchesne ex Poiret. , 2007, Journal of agricultural and food chemistry.

[42]  K. Aizawa,et al.  Quantitation of Carotenoids in Commonly Consumed Vegetables in Japan , 2007 .

[43]  Da-cheng Wang,et al.  Cucurbitane and hexanorcucurbitane glycosides from the fruits of Cucurbita pepo cv dayangua , 2007, Journal of Asian natural products research.

[44]  C. H. Azevedo-Meleiro,et al.  Qualitative and quantitative differences in carotenoid composition among Cucurbita moschata, Cucurbita maxima, and Cucurbita pepo. , 2007, Journal of agricultural and food chemistry.

[45]  M. Nee The domestication ofcucurbita (Cucurbitaceae) , 1990, Economic Botany.

[46]  F. Ahmed,et al.  Study of Nutritive Value and Medicinal Uses of Cultivated Cucurbits , 2008 .

[47]  H. Paris Historical records, origins, and development of the edible cultivar groups ofCucurbita pepo (Cucurbitaceae) , 1989, Economic Botany.

[48]  C. Kurz,et al.  HPLC-DAD-MS(n) characterisation of carotenoids from apricots and pumpkins for the evaluation of fruit product authenticity. , 2008, Food Chemistry.

[49]  Ray-Yu Yang,et al.  Content and distribution of flavonoids among 91 edible plant species. , 2008, Asia Pacific journal of clinical nutrition.

[50]  Hosahalli S. Ramaswamy,et al.  Pumpkin (Cucurbita maxima) seed oil extraction using supercritical carbon dioxide and physicochemical properties of the oil , 2009 .

[51]  Fa-sheng Li,et al.  New phenolic glycosides from the seeds of Cucurbita moschata , 2009, Journal of Asian natural products research.

[52]  A. Hamid,et al.  Effect of boiling and stir frying on total phenolics, carotenoids and radical scavenging activity of pumpkin (Cucurbita moschato) , 2009 .

[53]  D. Peričin,et al.  The distribution of phenolic acids in pumpkin’s hull-less seed, skin, oil cake meal, dehulled kernel and hull , 2009 .

[54]  R. A. Itle,et al.  Correlation Between L*a*b* Color Space Values and Carotenoid Content in Pumpkins and Squash (Cucurbita spp.) , 2009 .

[55]  Seong-Cheol Park,et al.  Antifungal mechanism of a novel antifungal protein from pumpkin rinds against various fungal pathogens. , 2009, Journal of agricultural and food chemistry.

[56]  Fa-sheng Li,et al.  Structures of new phenolic glycosides from the seeds of Cucurbita moschata. , 2009, Natural product communications.

[57]  B. Shah,et al.  Phytopharmacological Profile of Lagenaria siceraria: A Review , 2010 .

[58]  U. Chandrika,et al.  Carotenoid content and in vitro bioaccessibility of lutein in some leafy vegetables popular in Sri Lanka. , 2010, Journal of nutritional science and vitaminology.

[59]  K. G. Thomas,et al.  Hydrazine-Induced Room-Temperature Transformation of CdTe Nanoparticles to Nanowires , 2010 .

[60]  D. Sreeramulu,et al.  Antioxidant activity and phenolic content of roots, tubers and vegetables commonly consumed in India. , 2010 .

[61]  K. Jesionkowska,et al.  Studies on the usefulness of Cucurbita maxima for the production of ready-to-eat dried vegetable snacks with a high carotenoid content , 2010 .

[62]  M. Andjelkovic,et al.  Phenolic compounds and some quality parameters of pumpkin seed oil , 2010 .

[63]  S. Colucci,et al.  Downy mildew of cucurbits. , 2010 .

[64]  A. EI-Aziz Antimicrobial proteins and oil seeds from pumpkin (Cucurbita moschata). , 2011 .

[65]  A. Rufai,et al.  Phytochemical Screening and Antibacterial Activity of Cucurbita pepo (Pumpkin) against Staphylococcus aureus and Salmonella typhi , 2011 .

[66]  N. Gill,et al.  Isolation of Anti Ulcer Cucurbitane Type Triterpenoid from the Seeds of Cucurbita pepo , 2011 .

[67]  N. Jacobo-Valenzuela,et al.  Physicochemical, technological properties, and health-benefits of Cucurbita moschata Duchense vs. Cehualca: A Review , 2011 .

[68]  S. Badr,et al.  Chemical composition and biological activity of ripe pumpkin fruits (Cucurbita pepo L.) cultivated in Egyptian habitats , 2011, Natural product research.

[69]  N. Jacobo-Valenzuela,et al.  Chemical and physicochemical characterization of winter squash (Cucurbita moschata D.). , 2011 .

[70]  Ekrem Koksal,et al.  Purification and Characterization of Peroxidase from Sweet Gourd (Cucurbita moschata Lam. Poiret) , 2012 .

[71]  C. Elinge,et al.  Proximate, Mineral and Anti-nutrient Composition of Pumpkin (Cucurbitapepo L) Seeds Extract , 2012 .

[72]  L. Rezig,et al.  Chemical composition and profile characterisation of pumpkin (Cucurbita maxima) seed oil , 2012 .

[73]  S. Dubey OVERVIEW ON Cucurbita maxima , 2012 .

[74]  M. Y. Kim,et al.  Comparison of the chemical compositions and nutritive values of various pumpkin (Cucurbitaceae) species and parts , 2012, Nutrition research and practice.

[75]  L. D. Carvalho,et al.  Total carotenoid content, α-carotene and β-carotene, of landrace pumpkins (Cucurbita moschata Duch): A preliminary study , 2012 .

[76]  I. Iswaldi,et al.  Profiling of phenolic and other polar compounds in zucchini (Cucurbita pepo L.) by reverse-phase high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry , 2013 .

[77]  Steven C. Cermak,et al.  Seed oil content and fatty acid composition in a genebank collection of Cucurbita moschata Duchesne and C. argyrosperma C. Huber , 2013, Plant Genetic Resources.

[78]  P. Denev,et al.  Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts. , 2014, Acta biochimica Polonica.

[79]  Gao-feng Yuan,et al.  Conjugated linolenic acids and their bioactivities: a review. , 2014, Food & function.

[80]  Asma Sohail,et al.  CHARACTERIZATION AND ANTIBACTERIAL STUDY OF PUMPKIN SEED OIL (CUCURBITA PEPO) , 2014 .

[81]  Chengrong Wang,et al.  Ultrasound-assisted enzymatic extraction and antioxidant activity of polysaccharides from pumpkin (Cucurbita moschata). , 2014, Carbohydrate polymers.

[82]  Mahnaz Bahlgerdi,et al.  The Study of Plant Density and Planting Methods on Some Growth Characteristics, Seed and Oil Yield of Medicinal Pumpkin (Cucurbita Pepo Var. Styriaca, Cv. ‘Kaki) , 2014 .

[83]  Naglaa Z. H. Eleiwa,et al.  Phytochemical and Pharmacological Screening of Seeds and Fruits Pulp of Cucurbita moschata Duchesne Cultivated in Egypt , 2014 .

[84]  B. Rabrenović,et al.  The most important bioactive components of cold pressed oil from different pumpkin (Cucurbita pepo L.) seeds , 2014 .

[85]  Dong Chen,et al.  The effect of high hydrostatic pressure on the microbiological quality and physical–chemical characteristics of Pumpkin (Cucurbita maxima Duch.) during refrigerated storage , 2014 .

[86]  M. Irshad,et al.  Antioxidant Capacity and Phenolic Content of the Aqueous Extract of Commonly Consumed Cucurbits , 2014 .

[87]  Peyman Pakrokh Ghavi Modeling and Optimization of Ultrasound‐Assisted Extraction of Polysaccharide from the Roots of Althaea Officinalis , 2015 .

[88]  STUDIES ON THE POWDERY MILDEWS OF CUCURBITS , 2015 .

[89]  U. Kaushik,et al.  Cucurbitacins – An insight into medicinal leads from nature , 2015, Pharmacognosy reviews.

[90]  A. Zambrowicz,et al.  Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia) , 2015 .

[91]  T. Conrad,et al.  Diglycolic acid, the toxic metabolite of diethylene glycol, chelates calcium and produces renal mitochondrial dysfunction in vitro , 2016, Clinical toxicology.

[92]  M. Dinu,et al.  Biochemical Composition of Some Local Pumpkin Population , 2016 .

[93]  J. Tripathi,et al.  Impact of radiation processing on the stability of cucurbitacin glycosides in ready-to-cook (RTC) pumpkin during storage , 2016 .

[94]  R. Gutierrez,et al.  Review of Cucurbita pepo (Pumpkin) its Phytochemistry andPharmacology , 2016 .

[95]  M. Bannayan Growth Analysis of Pumpkin (Cucurbita pepo L.) Under Various Management Practices and Temperature Regimes , 2017 .

[96]  Garcia Gonzalez Jessica,et al.  CHEMICAL CHARACTERIZATION OF A HYPOGLYCEMIC EXTRACT FROM CUCURBITA FICIFOLIA BOUCHE THAT INDUCES LIVER GLYCOGEN ACCUMULATION IN DIABETIC MICE , 2017, African journal of traditional, complementary, and alternative medicines : AJTCAM.

[97]  G. Andolfo,et al.  Draft of Zucchini (Cucurbita pepo L.) Proteome: A Resource for Genetic and Genomic Studies , 2017, Front. Genet..

[98]  Z. Selamoğlu Polyphenolic Compounds in Human Health with Pharmacological Properties , 2017 .

[99]  A. Dar,et al.  Pumpkin the functional and therapeutic ingredient: A review , 2017 .

[100]  Hassan,et al.  A review on the ethnobotany, phytochemistry, pharmacology and nutritional composition of Cucurbita pepo L. , 2017, The Journal of Phytopharmacology.

[101]  R. RobertAugustoRodríguez,et al.  Características agronómicas y calidad nutricional de los frutos y semillas de zapallo Cucurbita sp. , 2018 .

[102]  G. Le Roux,et al.  Poisoning by non-edible squash: retrospective series of 353 patients from French Poison Control Centers , 2018, Clinical toxicology.

[103]  B. Salehi,et al.  Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion , 2018, Molecules.

[104]  B. Salehi,et al.  Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications. , 2018, Microbiological research.

[105]  B. Salehi,et al.  In vitro and in vivo assessment of free radical scavenging and antioxidant activities of Veronica persica Poir. , 2018, Cellular and molecular biology.

[106]  Z. Selamoğlu The Natural Products and Healthy Life , 2018 .

[107]  A. Mishra,et al.  Satyrium nepalense, a high altitude medicinal orchid of Indian Himalayan region: chemical profile and biological activities of tuber extracts. , 2018, Cellular and molecular biology.

[108]  B. Salehi,et al.  Bioactive compounds and health benefits of edible Rumex species-A review. , 2018, Cellular and molecular biology.

[109]  Z. Selamoğlu,et al.  Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential , 2019, Molecules.

[110]  Jeroen S. Dickschat Terpenes , 2019, Beilstein journal of organic chemistry.

[111]  C. Jeffrey 1. Systematics Of The Cucurbitaceae: An Overview , 2019, Biology and Utilization of the Cucurbitaceae.