Alsin/Rac1 signaling controls survival and growth of spinal motoneurons

Recessive mutations in alsin, a guanine‐nucleotide exchange factor for the GTPases Rab5 and Rac1, cause juvenile amyotrophic lateral sclerosis (ALS2) and related motoneuron disorders. Alsin function in motoneurons remained unclear because alsin knock‐out mice do not develop overt signs of motoneuron degeneration.

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