Research Review: The effects of mindfulness‐based interventions on cognition and mental health in children and adolescents – a meta‐analysis of randomized controlled trials

Background Mindfulness based interventions (MBIs) are an increasingly popular way of attempting to improve the behavioural, cognitive and mental health outcomes of children and adolescents, though there is a suggestion that enthusiasm has moved ahead of the evidence base. Most evaluations of MBIs are either uncontrolled or nonrandomized trials. This meta‐analysis aims to establish the efficacy of MBIs for children and adolescents in studies that have adopted a randomized, controlled trial (RCT) design. Methods A systematic literature search of RCTs of MBIs was conducted up to October 2017. Thirty‐three independent studies including 3,666 children and adolescents were included in random effects meta‐analyses with outcome measures categorized into cognitive, behavioural and emotional factors. Separate random effects meta‐analyses were completed for the seventeen studies (n = 1,762) that used an RCT design with an active control condition. Results Across all RCTs we found significant positive effects of MBIs, relative to controls, for the outcome categories of Mindfulness, Executive Functioning, Attention, Depression, Anxiety/Stress and Negative Behaviours, with small effect sizes (Cohen's d), ranging from .16 to .30. However, when considering only those RCTs with active control groups, significant benefits of an MBI were restricted to the outcomes of Mindfulness (d = .42), Depression (d = .47) and Anxiety/Stress (d = .18) only. Conclusions This meta‐analysis reinforces the efficacy of using MBIs for improving the mental health and wellbeing of youth as assessed using the gold standard RCT methodology. Future RCT evaluations should incorporate scaled‐up definitive trial designs to further evaluate the robustness of MBIs in youth, with an embedded focus on mechanisms of action.

[1]  I. Colman,et al.  Time trends in symptoms of mental illness in children and adolescents in Canada , 2014, Canadian Medical Association Journal.

[2]  S. Iliffe,et al.  Bmc Medical Research Methodology Open Access the Hawthorne Effect: a Randomised, Controlled Trial , 2022 .

[3]  Nick Black,et al.  The Cooksey review of UK health research funding , 2006, BMJ : British Medical Journal.

[4]  Per Capita,et al.  About the authors , 1995, Machine Vision and Applications.

[5]  Olga V. Demler,et al.  Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[6]  Harald Walach,et al.  Measuring Mindfulness in Insight Meditation ( Vipassana ) and Meditation-Based Psychotherapy : The Development of the Freiburg Mindfulness Inventory ( FMI ) by , 2008 .

[7]  P. Liehr,et al.  A pilot study examining the effect of mindfulness on depression and anxiety for minority children. , 2010, Archives of psychiatric nursing.

[8]  J. Kupersmidt,et al.  The impact of mindfulness education on elementary school students: evaluation of the Master Mind program , 2014, Advances in school mental health promotion.

[9]  L. Denson,et al.  The Long-Term Effects of Mindfulness-Based Cognitive Therapy as a Relapse Prevention Treatment for Major Depressive Disorder , 2010, Behavioural and Cognitive Psychotherapy.

[10]  Lisa Miller,et al.  Mindfulness Interventions with Youth: A Meta-Analysis , 2015 .

[11]  S. Smalley,et al.  Effects of Mindful Awareness Practices on Executive Functions in Elementary School Children , 2010 .

[12]  I. Grant,et al.  Test–retest reliability and practice effects of Expanded Halstead–Reitan Neuropsychological Test Battery , 1999, Journal of the International Neuropsychological Society.

[13]  Harald Walach,et al.  Measuring mindfulness in insight meditation (Vipassana) and meditationbased psychotherapy: The development of the Freiburg mindfulness inventory (FMI). Journal for Meditation and Meditation Research, . , 2001 .

[14]  Christine Burke,et al.  Effectiveness of a school-based mindfulness program for transdiagnostic prevention in young adolescents. , 2016, Behaviour research and therapy.

[15]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement , 2009, BMJ : British Medical Journal.

[16]  Simon B. Goldberg,et al.  Promoting prosocial behavior and self-regulatory skills in preschool children through a mindfulness-based Kindness Curriculum. , 2015, Developmental psychology.

[17]  M. Tingen,et al.  Impact of Stress Reduction Interventions on Hostility and Ambulatory Systolic Blood Pressure in African American Adolescents , 2011, The Journal of black psychology.

[18]  Michael C. Mullarkey,et al.  A School-Based Mindfulness Pilot Study for Ethnically Diverse At-Risk Adolescents , 2016, Mindfulness.

[19]  P. Grossman,et al.  Mindfulness-based stress reduction and health benefits. A meta-analysis. , 2004, Journal of psychosomatic research.

[20]  Jacob Cohen Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[21]  V. Barnes,et al.  Impact of Meditation on Resting and Ambulatory Blood Pressure and Heart Rate in Youth , 2004, Psychosomatic medicine.

[22]  A. Jha,et al.  Mindfulness training improves attentional task performance in incarcerated youth: a group randomized controlled intervention trial , 2013, Front. Psychol..

[23]  The Effects of Mindful Awareness Teaching Practices on the Executive Functions of Students in an Urban, Low Income Middle School , 2011 .

[24]  Z. Segal,et al.  Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse: An Individual Patient Data Meta-analysis From Randomized Trials. , 2016, JAMA psychiatry.

[25]  R. Ryan,et al.  Mindfulness: Theoretical Foundations and Evidence for its Salutary Effects , 2007 .

[26]  R. Ryan,et al.  The benefits of being present: mindfulness and its role in psychological well-being. , 2003, Journal of personality and social psychology.

[27]  Sam Himelstein,et al.  Does Mindfulness Meditation Increase Effectiveness of Substance Abuse Treatment with Incarcerated Youth? A Pilot Randomized Controlled Trial , 2015 .

[28]  S. Lynn,et al.  Mindfulness Skills and Depressive Symptoms: A Longitudinal Study , 2010 .

[29]  Willoughby B. Britton,et al.  A randomized controlled pilot trial of classroom-based mindfulness meditation compared to an active control condition in sixth-grade children. , 2014, Journal of school psychology.

[30]  S. Morris Estimating Effect Sizes From Pretest-Posttest-Control Group Designs , 2008 .

[31]  Manoj Sharma,et al.  Mindfulness-based stress reduction for healthy individuals: A meta-analysis. , 2015, Journal of psychosomatic research.

[32]  G. Harshfield,et al.  Impact of breathing awareness meditation on ambulatory blood pressure and sodium handling in prehypertensive African American adolescents. , 2008, Ethnicity & disease.

[33]  Jacob Cohen,et al.  A power primer. , 1992, Psychological bulletin.

[34]  S. Blakemore,et al.  Development of the adolescent brain: implications for executive function and social cognition. , 2006 .

[35]  W. Gropp,et al.  Accepted for publication , 2001 .

[36]  Lisa Miller,et al.  A Randomized Trial of Mindfulness-Based Cognitive Therapy for Children: Promoting Mindful Attention to Enhance Social-Emotional Resiliency in Children , 2010 .

[37]  Zac E. Imel,et al.  The validation of an active control intervention for Mindfulness Based Stress Reduction (MBSR). , 2012, Behaviour research and therapy.

[38]  Jay N Giedd,et al.  The teen brain: insights from neuroimaging. , 2008, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[39]  J. Kabat-Zinn,et al.  An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. , 1982, General hospital psychiatry.

[40]  Willem Kuyken,et al.  Home practice in Mindfulness-Based Cognitive Therapy and Mindfulness-Based Stress Reduction: A systematic review and meta-analysis of participants' mindfulness practice and its association with outcomes , 2017, Behaviour research and therapy.

[41]  Julian P T Higgins,et al.  Association Between Risk-of-Bias Assessments and Results of Randomized Trials in Cochrane Reviews: The ROBES Meta-Epidemiologic Study , 2017, American journal of epidemiology.

[42]  R. Roeser,et al.  Mindfulness and compassion training in adolescence: a developmental contemplative science perspective. , 2014, New directions for youth development.

[43]  Lynn C Holley,et al.  Mindfulness Training for Elementary School Students , 2005 .

[44]  C. Zahn-Waxler,et al.  A Pilot Study of Contemplative Practices with Economically Disadvantaged Preschoolers: Children’s Empathic and Self-Regulatory Behaviors , 2016 .

[45]  Jordan T. Quaglia,et al.  Pilot randomized controlled trial of a mindfulness-based group intervention in adolescent girls at risk for type 2 diabetes with depressive symptoms. , 2017, Complementary therapies in medicine.

[46]  K. Alexander,et al.  A Randomized Controlled Trial Examining the Effect of Mindfulness Meditation on Working Memory Capacity in Adolescents. , 2016, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[47]  A FRAMEWORK FOR DEVELOPMENT AND EVALUATION OF RCTs FOR COMPLEX INTERVENTIONS TO IMPROVE HEALTH , 2000 .

[48]  G. Keri,et al.  The Promotion of Social Awareness: Powerful Lessons from the Partnership of Developmental Theory and Classroom Practice , 2004 .

[49]  Harald Walach,et al.  Mindfulness-based interventions in schools—a systematic review and meta-analysis , 2014, Front. Psychol..

[50]  Christine Burke,et al.  A randomized controlled evaluation of a secondary school mindfulness program for early adolescents: Do we have the recipe right yet? , 2017, Behaviour research and therapy.

[51]  P. Easterbrook,et al.  Publication bias in clinical research , 1991, The Lancet.

[52]  Sara B. Johnson,et al.  School-based mindfulness instruction for urban male youth: a small randomized controlled trial. , 2013, Preventive medicine.

[53]  Adele Diamond,et al.  Enhancing cognitive and social-emotional development through a simple-to-administer mindfulness-based school program for elementary school children: a randomized controlled trial. , 2015, Developmental psychology.

[54]  G. Martin,et al.  Taming the adolescent mind: a randomised controlled trial examining clinical efficacy of an adolescent mindfulness-based group programme. , 2015, Child and adolescent mental health.

[55]  B. Zumbo,et al.  A Validation Study of the Mindful Attention Awareness Scale Adapted for Children , 2014 .

[56]  M. Tingen,et al.  Breathing awareness meditation and LifeSkills Training programs influence upon ambulatory blood pressure and sodium excretion among African American adolescents. , 2011, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[57]  J. Brewer,et al.  What defines mindfulness-based programs? The warp and the weft , 2016, Psychological Medicine.

[58]  J. Labus,et al.  Cognitive behavioral therapy for depressed adolescents exposed to interpersonal trauma: an initial effectiveness trial. , 2014, Psychotherapy.

[59]  M. Tingen,et al.  Influences of Family Environment and Meditation Efficacy on Hemodynamic Function among African American Adolescents , 2010, Journal of complementary & integrative medicine.

[60]  J. M. Aguilar-Parra,et al.  [Effects of a mindfulness intervention in Chilean high schoolers]. , 2017, Revista medica de Chile.

[61]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2009, Journal of clinical epidemiology.

[62]  Guillaume Fortin,et al.  Mindfulness-based therapy: a comprehensive meta-analysis. , 2013, Clinical psychology review.

[63]  C. Justo Efectos de un programa de meditación sobre los niveles de creatividad verbal de un grupo de alumnos/as de Bachillerato , 2009 .

[64]  Brandy R. Maynard,et al.  Mindfulness‐based interventions for improving cognition, academic achievement, behavior, and socioemotional functioning of primary and secondary school students , 2017 .

[65]  Gregory T. Smith,et al.  Using Self-Report Assessment Methods to Explore Facets of Mindfulness , 2006, Assessment.

[66]  T. Wade,et al.  Mindfulness-based prevention for eating disorders: A school-based cluster randomized controlled study. , 2015, The International journal of eating disorders.

[67]  K. Weare Developing the Emotionally Literate School , 2003 .

[68]  Z. Segal,et al.  Mindfulness: A Proposed Operational Definition , 2004 .

[69]  Kevin D. Carlson,et al.  Impact of Experimental Design on Effect Size: Findings From the Research Literature on Training , 1999 .

[70]  J. Ellen,et al.  School-Based Mindfulness Instruction: An RCT , 2016, Pediatrics.

[71]  David A. Klingbeil,et al.  Mindfulness-based interventions with youth: A comprehensive meta-analysis of group-design studies. , 2017, Journal of school psychology.

[72]  Robert L. Leahy,et al.  The Construction of the Self: A Developmental Perspective , 2001, Journal of Cognitive Psychotherapy.

[73]  Nirbhay N. Singh,et al.  A Systematic Review of Mindfulness-Based Interventions for Youth in School Settings , 2015, Mindfulness.

[74]  S. Shapiro,et al.  Mindfulness-based stress reduction for the treatment of adolescent psychiatric outpatients: A randomized clinical trial. , 2009, Journal of consulting and clinical psychology.

[75]  Lucy B. G. Tan A critical review of adolescent mindfulness-based programmes , 2015, Clinical child psychology and psychiatry.

[76]  M. Greenberg,et al.  Nurturing Mindfulness in Children and Youth: Current State of Research , 2012 .

[77]  José Gallego,et al.  The Applications of Mindfulness with Students of Secondary School: Results on the Academic Performance, Self-concept and Anxiety , 2010, WSKS.

[78]  N. Heath,et al.  Effectiveness of a Classroom Mindfulness Coloring Activity for Test Anxiety in Children , 2015 .

[79]  Rachel Potek Mindfulness as a school-based prevention program and its effect on adolescent stress, anxiety and emotion regulation , 2012 .

[80]  R. DeRubeis,et al.  Allegiance in Psychotherapy Outcome Research: Separating Association From Bias , 2009 .

[81]  Sarah-Jayne Blakemore,et al.  Is adolescence a sensitive period for sociocultural processing? , 2014, Annual review of psychology.

[82]  T. Dalgleish,et al.  The effectiveness and cost-effectiveness of a mindfulness training programme in schools compared with normal school provision (MYRIAD): study protocol for a randomised controlled trial , 2017, Trials.

[83]  D M Caldwell,et al.  Waiting list may be a nocebo condition in psychotherapy trials: a contribution from network meta‐analysis , 2014, Acta psychiatrica Scandinavica.

[84]  P. M. Podsakoff,et al.  Self-Reports in Organizational Research: Problems and Prospects , 1986 .

[85]  J. Ricarte,et al.  Mindfulness-Based Intervention in a Rural Primary School: Effects on Attention, Concentration and Mood , 2015 .

[86]  H. Dubben,et al.  Systematic review of publication bias in studies on publication bias , 2005, BMJ : British Medical Journal.