Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

[1]  Hui Li,et al.  Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy , 2017, Science Translational Medicine.

[2]  L. Liao,et al.  The histone demethylase Kdm3a is required for normal epithelial proliferation, ductal elongation and tumor growth in the mouse mammary gland , 2017, Oncotarget.

[3]  M. Claudino,et al.  Detrimental role of lysyl oxidase in cardiac remodeling. , 2017, Journal of molecular and cellular cardiology.

[4]  Saptarsi M. Haldar,et al.  BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure , 2017, Science Translational Medicine.

[5]  N. Frangogiannis,et al.  The extracellular matrix in myocardial injury, repair, and remodeling , 2017, The Journal of clinical investigation.

[6]  I. Jackson,et al.  KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability , 2017, The Journal of cell biology.

[7]  M. Fornage,et al.  Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association , 2017, Circulation.

[8]  W. Reik,et al.  The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy , 2017, The Journal of clinical investigation.

[9]  D. Kass,et al.  Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease. , 2016, Handbook of experimental pharmacology.

[10]  Xiuhua Wang,et al.  Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63–Integrin &bgr;1 Interaction , 2017, Hypertension.

[11]  Stuart A. Cook,et al.  Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy. , 2016, Journal of the American College of Cardiology.

[12]  Peter A. Jones,et al.  Targeting the cancer epigenome for therapy , 2016, Nature Reviews Genetics.

[13]  K. Yutzey,et al.  Cardiac Fibrosis: The Fibroblast Awakens. , 2016, Circulation research.

[14]  J. Gardner,et al.  Featured Article: Cardioprotective effects of lysyl oxidase inhibition against volume overload-induced extracellular matrix remodeling , 2016, Experimental biology and medicine.

[15]  Yaqin Xu,et al.  Systemic injection of AAV9 carrying a periostin promoter targets gene expression to a myofibroblast-like lineage in mouse hearts after reperfused myocardial infarction , 2016, Gene Therapy.

[16]  J. Rizo,et al.  KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. , 2015, Chemistry & biology.

[17]  Joseph A. Hill,et al.  Abstract 261: Foxo4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1 , 2015 .

[18]  Peili Bu,et al.  The histone demethylase PHF8 represses cardiac hypertrophy upon pressure overload. , 2015, Experimental cell research.

[19]  Qing-Jun Zhang,et al.  Histone methylations in heart development, congenital and adult heart diseases. , 2015, Epigenomics.

[20]  T. Secomb,et al.  Effect of Lysyl Oxidase Inhibition on Angiotensin II-Induced Arterial Hypertension, Remodeling, and Stiffness , 2015, PloS one.

[21]  M. Biddle,et al.  A report from the American Heart Association Council on Cardiovascular and Stroke Nursing. , 2015, The Journal of cardiovascular nursing.

[22]  Praveen Shukla,et al.  Chemically defined generation of human cardiomyocytes , 2014, Nature Methods.

[23]  B. Cui,et al.  Chemically Defined and Small Molecule-Based Generation of Human Cardiomyocytes , 2014, Nature methods.

[24]  J. Molkentin,et al.  Myofibroblasts: trust your heart and let fate decide. , 2014, Journal of molecular and cellular cardiology.

[25]  L. D. de Windt,et al.  Regulation of fetal gene expression in heart failure. , 2013, Biochimica et biophysica acta.

[26]  D. Wilhelm,et al.  Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a , 2013, Science.

[27]  Joseph A. Hill,et al.  Pathological Ventricular Remodeling: Mechanisms Part 1 of 2 , 2013, Circulation.

[28]  S. Peña-Llopis,et al.  A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth , 2013, Nature Communications.

[29]  J. Backs,et al.  HDAC4 controls histone methylation in response to elevated cardiac load. , 2013, The Journal of clinical investigation.

[30]  J. Molkentin,et al.  Signaling effectors underlying pathologic growth and remodeling of the heart. , 2013, The Journal of clinical investigation.

[31]  D. Kass,et al.  Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling , 2012, Circulation.

[32]  M. Zile,et al.  Changes in plasma profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in stress-induced cardiomyopathy. , 2012, Journal of cardiac failure.

[33]  De-Pei Liu,et al.  The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. , 2011, The Journal of clinical investigation.

[34]  Ayan R Patel,et al.  Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. , 2011, JACC. Cardiovascular imaging.

[35]  W. Brown Framingham Heart Study. , 2011, Journal of clinical lipidology.

[36]  Dong I. Lee,et al.  Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5. , 2010, Journal of the American College of Cardiology.

[37]  Roger R Markwald,et al.  Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β. , 2010, The Journal of clinical investigation.

[38]  S. Colan,et al.  Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy. , 2010, The New England journal of medicine.

[39]  P. Dorrestein,et al.  PHF8 Mediates Histone H4 Lysine 20 Demethylation Events Involved in Cell Cycle Progression , 2010, Nature.

[40]  Xiang Wang,et al.  PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis , 2010, Cell Research.

[41]  B. Chazotte Labeling cytoskeletal F-actin with rhodamine phalloidin or fluorescein phalloidin for imaging. , 2010, Cold Spring Harbor protocols.

[42]  Arantxa González,et al.  Circulating Biomarkers of Collagen Metabolism in Cardiac Diseases , 2010, Circulation.

[43]  Yang Shi,et al.  Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases , 2010, Nature Structural &Molecular Biology.

[44]  Stephanie L. K. Bowers,et al.  Cardiac Fibroblast: The Renaissance Cell , 2009, Circulation research.

[45]  Xian Chen,et al.  Jmjd1a Demethylase-regulated Histone Modification Is Essential for cAMP-response Element Modulator-regulated Gene Expression and Spermatogenesis* , 2009, The Journal of Biological Chemistry.

[46]  Yi Zhang,et al.  Role of Jhdm2a in regulating metabolic gene expression and obesity resistance , 2009, Nature.

[47]  James B. Mitchell,et al.  Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin: Efficacy of Recoupling Nitric Oxide Synthase as a Therapeutic Strategy , 2008, Circulation.

[48]  Y. Mishina,et al.  Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis , 2007, Nature.

[49]  E. Olson,et al.  Toward transcriptional therapies for the failing heart: chemical screens to modulate genes. , 2005, The Journal of clinical investigation.

[50]  M. Zile,et al.  Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition. , 2005, American journal of physiology. Heart and circulatory physiology.

[51]  J. Bos,et al.  FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK , 2004, The EMBO journal.

[52]  D. Levy,et al.  Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study. , 2004, European heart journal.

[53]  E. Creemers,et al.  Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice. , 2003, American journal of physiology. Heart and circulatory physiology.

[54]  E. Olson,et al.  Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[55]  M. Zile,et al.  Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. , 2000, Journal of molecular and cellular cardiology.