论文信息 - Pharmacokinetics of Fluconazole in Serum and Cerebrospinal Fluid in a Patient with AIDS and Cryptococcal Meningitis

Pharmacokinetics of Fluconazole in Serum and Cerebrospinal Fluid in a Patient with AIDS and Cryptococcal Meningitis

The detailed pharmacokinetics of fluconazole in serum and cerebrospinal fluid (CSF) were studied in a patient with acquired immunodeficiency syndrome and cryptococcal meningitis, after an intravenous dose of 400 mg. Fluconazole exhibited a serum elimination half‐life of 34.2 hours, distribution volume of 0.56 17kg, and clearance of 0.19 ml/min/kg. Peak CSF concentration occurred at 4 hours after the dose. Overall penetration of fluconazole based on the ratio of areas under the curve of CSF to serum was 70%. The drug exhibited an excellent pharmacokinetic profile for treatment of central nervous system fungal infections.

I. Fong | T. Chin | A. Vandenbroucke | T. Chin

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