Selective regulation of cellular processes via protein cascades acting as band‐pass filters for time‐limited oscillations

We show by mathematical modelling that a two‐level protein cascade can act as a band‐pass filter for time‐limited oscillations. The band‐pass filters are then combined into a network of three‐level signalling cascades that by filtering the frequency of time‐limited oscillations selectively switches cellular processes on and off. The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time‐limited calcium oscillations.

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