Antibiotics from the Nematode-Trapping Basidiomycete Nematoctonus robustus

Abstract Pleurotin, dihydropleurotinic acid and leucopleurotin, metabolites previously isolated from cultures of a Hohenbuehelia species, were obtained from cultures of the nematode-trapping deuteromycete Nematoctonus robustus. Crystals suitable for X-ray analysis were obtained from dihydropleurotinic acid. All three compounds exhibited antibacterial, antifungal and cytotoxic but no nematicidal activities. The production of these compounds by Nematoctonus, a known anamorph of Hohenbuehelia reveals also a close chemotaxonomic relationship between the sexual and imperfect stage of these basidiomycetes.

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