Amygdala, affect and cognition: evidence from 10 patients with Urbach-Wiethe disease.

Patients with Urbach-Wiethe disease constitute a unique nature experiment as more than half have bilaterally symmetrical damage in the amygdaloid region. Ten such patients were studied neuropsychologically and, nine of them, neuroradiologically with static (CT) and functional imaging techniques [single-photon emission computed tomography (SPECT) and PET]. Their principal bilateral amygdala damage was confirmed. Neuropsychologically, the patients showed cognitively little deviation from normal subjects, while they differed emotionally. This was evident in their judgement of all emotions in facial expressions, in an odour-figure association test as well as in remembering negative and positive pictures. This suggests that the human amygdala influences both negative and positive emotional processing.

[1]  R. Rosenberg,et al.  Neurologic involvement in Urbach‐Wiethe's disease (lipoid proteinosis) , 1971, Neurology.

[2]  P. Ekman.  Pictures of Facial Affect , 1976 .

[3]  A. Benton.  Contributions to Neuropsychological Assessment: A Clinical Manual , 1983 .

[4]  C. Reynolds,et al.  Wechsler memory scale-revised , 1988 .

[5]  Robert A. Bornstein,et al.  The Wechsler Memory Scale—Revised , 1990 .

[6]  O. Spreen,et al.  A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary , 1991 .

[7]  Jacob Cohen,et al.  A power primer. , 1992, Psychological bulletin.

[8]  M. Bradley,et al.  Remembering pictures: pleasure and arousal in memory. , 1992, Journal of experimental psychology. Learning, memory, and cognition.

[9]  J. Kessler,et al.  The amygdala's contribution to memory—a study on two patients with Urbach-Wiethe disease , 1994 .

[10]  Pasquale Calabrese,et al.  The amygdala's contribution to memory—a study on two patients with Urbach‐Wiethe disease , 1994, Neuroreport.

[11]  D. Perrett,et al.  A differential neural response in the human amygdala to fearful and happy facial expressions , 1996, Nature.

[12]  S. Rauch,et al.  Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression , 1996, Neuron.

[13]  J L McGaugh,et al.  Amygdala activity at encoding correlated with long-term, free recall of emotional information. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[14]  R. Adolphs.  Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala , 1997 .

[15]  R. Adolphs,et al.  Impaired declarative memory for emotional material following bilateral amygdala damage in humans. , 1997, Learning & memory.

[16]  Ralph Adolphs,et al.  Fear and the human amygdala , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  Thomas P. Naidich,et al.  Urbach-Wiethe Disease(Lipoid Proteinosis) , 1998, Pediatric Neurosurgery.

[18]  J. Desmond,et al.  Hemispheric asymmetry for emotional stimuli detected with fMRI , 1998, Neuroreport.

[19]  A. Anderson,et al.  Specifying the Contributions of the Human Amygdala to Emotional Memory: A Case Study , 1998 .

[20]  Karl J. Friston,et al.  A neuromodulatory role for the human amygdala in processing emotional facial expressions. , 1998, Brain : a journal of neurology.

[21]  H. Markowitsch.  Differential contribution of right and left amygdala to affective information processing. , 1998, Behavioural neurology.

[22]  James L. McGaugh,et al.  Mechanisms of emotional arousal and lasting declarative memory , 1998, Trends in Neurosciences.

[23]  R. Adolphs,et al.  Normal recognition of emotional similarity between facial expressions following bilateral amygdala damage , 1999, Neuropsychologia.

[24]  R. Dolan,et al.  Common effects of emotional valence, arousal and attention on neural activation during visual processing of pictures , 1999, Neuropsychologia.

[25]  Scott T. Grafton,et al.  Amygdala activity related to enhanced memory for pleasant and aversive stimuli , 1999, Nature Neuroscience.

[26]  Gary H. Glover,et al.  fMRI identifies a network of structures correlated with retention of positive and negative emotional memory , 1999, Psychobiology.

[27]  N. Costes,et al.  Emotional Responses to Pleasant and Unpleasant Olfactory, Visual, and Auditory Stimuli: a Positron Emission Tomography Study , 2000, The Journal of Neuroscience.

[28]  R. Adolphs,et al.  Impaired emotional declarative memory following unilateral amygdala damage. , 2000, Learning & memory.

[29]  E. Stein,et al.  Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. , 2000, The American journal of psychiatry.

[30]  The possible contribution of the amygdala to memory , 2000 .

[31]  Larry Cahill.  The amygdala and emotional memory , 2000 .

[32]  J. Gabrieli,et al.  Event-Related Activation in the Human Amygdala Associates with Later Memory for Individual Emotional Experience , 2000, The Journal of Neuroscience.

[33]  R. Blair,et al.  Dissociation between 'theory of mind' and executive functions in a patient with early left amygdala damage. , 2001, Brain : a journal of neurology.

[34]  Silke Lux,et al.  Verbaler Lern- und Merkfähigkeitstest , 2001 .

[35]  B. Steinhoff,et al.  Amygdala lesion in temporal lobe epilepsy subjects impairs associative learning of emotional facial expressions , 2001, Neuropsychologia.

[36]  Thomas J. Ross,et al.  Amygdala response to both positively and negatively valenced stimuli , 2001, Neuroreport.

[37]  John M Hoffman,et al.  Ecstasy and Agony: Activation of the Human Amygdala in Positive and Negative Emotion , 2002, Psychological science.

[38]  S. Hamann,et al.  Positive and negative emotional verbal stimuli elicit activity in the left amygdala , 2002, Neuroreport.

[39]  Stephan Eliez,et al.  Amygdalar activation associated with positive and negative facial expressions , 2002, Neuroreport.

[40]  B. Papps,et al.  Dissociation of affective modulation of recollective and perceptual experience following amygdala damage , 2003, Journal of neurology, neurosurgery, and psychiatry.