Dysregulation of Protein Kinase A Signaling in the Aged Prefrontal Cortex New Strategy for Treating Age-Related Cognitive Decline
暂无分享,去创建一个
A. Arnsten | R. Duman | S. Birnbaum | B. Ramos | I. Lindenmayer | S. Newton
[1] B. Winblad,et al. The antidepressant and antiinflammatory effects of rolipram in the central nervous system. , 2006, CNS drug reviews.
[2] A. Granholm,et al. Age-related deficits as working memory load increases: relationships with growth factors , 2003, Neurobiology of Aging.
[3] M. Kelz,et al. Inducible and brain region-specific CREB transgenic mice. , 2002, Molecular pharmacology.
[4] Patrick R Hof,et al. Morphological alterations in neurons forming corticocortical projections in the neocortex of aged Patas monkeys , 2002, Neuroscience Letters.
[5] I. Izquierdo,et al. The ubiquitin–proteasome cascade is required for mammalian long‐term memory formation , 2001, The European journal of neuroscience.
[6] C. Wellman,et al. Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. , 2001, Journal of neurobiology.
[7] J. Desmond,et al. Prefrontal regions involved in keeping information in and out of mind. , 2001, Brain : a journal of neurology.
[8] Lawrence J. Whalley,et al. The Ageing Brain , 2001 .
[9] R U Muller,et al. Parallel Instabilities of Long-Term Potentiation, Place Cells, and Learning Caused by Decreased Protein Kinase A Activity , 2000, The Journal of Neuroscience.
[10] Joseph E LeDoux,et al. Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala , 2000, The Journal of Neuroscience.
[11] E R Kandel,et al. Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation , 2000, The Journal of Neuroscience.
[12] I. Izquierdo,et al. Molecular signalling pathways in the cerebral cortex are required for retrieval of one-trial avoidance learning in rats , 2000, Behavioural Brain Research.
[13] J. O'Donnell,et al. Inhibition of Cyclic AMP Phosphodiesterase (PDE4) Reverses Memory Deficits Associated with NMDA Receptor Antagonism , 2000, Neuropsychopharmacology.
[14] J. O'Donnell,et al. Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats , 2000, Psychopharmacology.
[15] Endel Tulving,et al. Prefrontal cortex and episodic memory retrieval mode. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[16] JaneR . Taylor,et al. A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex , 1999, Biological Psychiatry.
[17] JaneR . Taylor,et al. Activation of cAMP-Dependent Protein Kinase A in Prefrontal Cortex Impairs Working Memory Performance , 1999, The Journal of Neuroscience.
[18] D. Storm,et al. Regulation and Immunohistochemical Localization of βγ-Stimulated Adenylyl Cyclases in Mouse Hippocampus , 1999, The Journal of Neuroscience.
[19] E. Kandel,et al. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[20] K. Widnell,et al. Cell Type‐Specific Regulation of CREB Gene Expression: Mutational Analysis of CREB Promoter Activity , 1998, Journal of neurochemistry.
[21] E R Kandel,et al. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. , 1998, Learning & memory.
[22] Eric R Kandel,et al. Postsynaptic Induction and PKA-Dependent Expression of LTP in the Lateral Amygdala , 1998, Neuron.
[23] A. Arnsten. The Biology of Being Frazzled , 1998, Science.
[24] A. Arnsten,et al. The α-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys , 1998, Psychopharmacology.
[25] M. Gallagher,et al. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[26] M. Albert,et al. The ageing brain: normal and abnormal memory. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[27] JaneR . Taylor,et al. Opposite Modulation of Opiate Withdrawal Behaviors on Microinfusion of a Protein Kinase A Inhibitor Versus Activator into the Locus Coeruleus or Periaqueductal Gray , 1997, The Journal of Neuroscience.
[28] G. Aghajanian,et al. CREB (cAMP Response Element-Binding Protein) in the Locus Coeruleus: Biochemical, Physiological, and Behavioral Evidence for a Role in Opiate Dependence , 1997, The Journal of Neuroscience.
[29] R. Killiany,et al. Patterns of cognitive decline in aged rhesus monkeys , 1997, Behavioural Brain Research.
[30] I Izquierdo,et al. Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[31] E. Kandel,et al. Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory , 1997, Cell.
[32] T. Yamamoto,et al. Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents. , 1997, European journal of pharmacology.
[33] H. Tanila,et al. The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats , 1996, Brain Research Bulletin.
[34] H. Tanila,et al. Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys , 1996, Pharmacology Biochemistry and Behavior.
[35] R. West,et al. An application of prefrontal cortex function theory to cognitive aging. , 1996, Psychological bulletin.
[36] Daniel L. Schacter,et al. The role of hippocampus and frontal cortex in age‐ related memory changes: a PET study , 1996, Neuroreport.
[37] R. Duman,et al. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[38] Y. Itoyama,et al. Age-related changes in bindings of second messengers in the rat brain , 1995, Brain Research.
[39] R. Knight,et al. Prefrontal alterations during memory processing in aging. , 1995, Cerebral cortex.
[40] E Tulving,et al. Functional role of the prefrontal cortex in retrieval of memories: a PET study , 1995, Neuroreport.
[41] R. Iyengar,et al. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[42] R. Taussig,et al. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. , 1994, The Journal of biological chemistry.
[43] E. Kandel,et al. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. , 1993, Science.
[44] R. Iyengar. Molecular and functional diversity of mammalian Gs‐stimulated adenylyl cyclases , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[45] H. Tanila,et al. Effects of medetomidine, an α-2 adrenoceptor agonist, and atipamezole, an α-2 antagonist, on spatial memory performance in adult and aged rats , 1992 .
[46] S. Ando,et al. Longitudinal study on age-related changes of working and reference memory in the rat , 1991, Neuroscience Letters.
[47] M. Montminy,et al. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 , 1989, Cell.
[48] D. Amaral,et al. Evidence for task-dependent memory dysfunction in the aged monkey , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[49] P. Goldman-Rakic,et al. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[50] P. Goldman-Rakic,et al. Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. , 1985, Science.
[51] F. Morrell,et al. Pentoxifylline reverses age-related deficits in spatial memory. , 1984, Behavioral and neural biology.
[52] D. Quartermain,et al. Brain cyclic AMP and memory in mice , 1982, Pharmacology Biochemistry and Behavior.
[53] H R Johnson,et al. Aging in the rhesus monkey: debilitating effects on short-term memory. , 1978, Journal of gerontology.
[54] M. Feldman,et al. Loss of dendritic spines in aging cerebral cortex , 1975, Anatomy and Embryology.
[55] I. Divac. Frontal lobe system and spatial reversal in the rat. , 1971, Neuropsychologia.
[56] K. Jellinger. Principles of frontal lobe function , 2003 .
[57] H. Tanila. Noradrenergic regulation of hippocampal place cells , 2001, Hippocampus.
[58] A. Arnsten,et al. Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine α-1 receptor mechanisms , 2000 .
[59] R. Knight,et al. Prefrontal deficits in attention and inhibitory control with aging. , 1997, Cerebral cortex.
[60] M. Gallagher,et al. The use of animal models to study the effects of aging on cognition. , 1997, Annual review of psychology.
[61] R. Bernabeu,et al. Involvement of hippocampal D1/D5 receptor-cAMP signaling pathways in a late memory consolidation phase of an aversively-motivated task in rats , 1997 .