HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation
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J. Pouysségur | E. Berra | D. Richard | E. Gothié | Edurne Berra | Emmanuel Gothié | Jacques Pouysségur
[1] J. Pouysségur,et al. p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1* , 1999, The Journal of Biological Chemistry.
[2] C. Wykoff,et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis , 1999, Nature.
[3] J. Pouysségur,et al. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. , 2000, The Journal of biological chemistry.
[4] O. Hankinson,et al. Cloning of a factor required for activity of the Ah (dioxin) receptor. , 1991, Science.
[5] G. Semenza,et al. Purification and Characterization of Hypoxia-inducible Factor 1 (*) , 1995, The Journal of Biological Chemistry.
[6] Arnold J. Levine,et al. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 , 1990, Cell.
[7] M. Oren,et al. Mdm2 promotes the rapid degradation of p53 , 1997, Nature.
[8] J. Caro,et al. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. , 1997, The Journal of biological chemistry.
[9] A. Koong,et al. Loss of PTEN facilitates HIF-1-mediated gene expression. , 2000, Genes & development.
[10] T. Maniatis,et al. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. , 1995, Genes & development.
[11] G. Semenza,et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. , 2000, Genes & development.
[12] G. Semenza,et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. , 2000, Cancer research.
[13] D. Mottet,et al. ERK activation upon hypoxia: involvement in HIF‐1 activation , 2000, FEBS letters.
[14] G. Semenza,et al. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. , 1999, Annual review of cell and developmental biology.
[15] J. Gutkind,et al. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. , 2000, Cancer research.
[16] Aaron Ciechanover,et al. The ubiquitin–proteasome pathway: on protein death and cell life , 1998, The EMBO journal.
[17] Yuichi Makino,et al. Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway* , 1999, The Journal of Biological Chemistry.
[18] Stephen N. Jones,et al. Regulation of p53 stability by Mdm2 , 1997, Nature.
[19] L. Neckers,et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1α , 1998, Nature.
[20] H. Pahl,et al. Phosphorylation of human I kappa B‐alpha on serines 32 and 36 controls I kappa B‐alpha proteolysis and NF‐kappa B activation in response to diverse stimuli. , 1995, The EMBO journal.
[21] M. Krasnow,et al. The Hypoxic Response: Huffing and HIFing , 1997, Cell.
[22] J. Pouysségur,et al. Oncogenic Raf-1 Activates p70 S6 Kinase via a Mitogen-activated Protein Kinase-independent Pathway* , 1996, The Journal of Biological Chemistry.
[23] L. Huang,et al. Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway , 1998 .
[24] M. McMahon,et al. Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1 , 1994, Molecular and cellular biology.
[25] G. Semenza,et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[26] Y Taya,et al. DNA damage induces phosphorylation of the amino terminus of p53. , 1997, Genes & development.
[27] L. Poellinger,et al. Mechanism of regulation of the hypoxia‐inducible factor‐1α by the von Hippel‐Lindau tumor suppressor protein , 2000, The EMBO journal.
[28] G. Semenza. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. , 1998, Current opinion in genetics & development.
[29] Eamonn R. Maher,et al. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein* , 2000, The Journal of Biological Chemistry.
[30] M. McMahon,et al. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase , 1993, Molecular and cellular biology.
[31] M. Ivan,et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein , 2000, Nature Cell Biology.
[32] Yoichi Taya,et al. DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 , 1997, Cell.
[33] D. Livingston,et al. Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit* , 1996, The Journal of Biological Chemistry.
[34] A. Levine,et al. Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6 , 1998, Molecular and Cellular Biology.
[35] P. W. Conrad,et al. EPAS1 trans-Activation during Hypoxia Requires p42/p44 MAPK* , 1999, The Journal of Biological Chemistry.