A review of stimuli-responsive nanocarriers for drug and gene delivery.

[1]  V. Torchilin Targeted pharmaceutical nanocarriers for cancer therapy and imaging , 2007, The AAPS Journal.

[2]  Y. Nagasaki,et al.  Synthesis, characterization, and biomedical applications of core–shell-type stimuli-responsive nanogels – Nanogel composed of poly[2-(N,N-diethylamino)ethyl methacrylate] core and PEG tethered chains , 2007 .

[3]  Z. Duan,et al.  Paclitaxel and ceramide co‐administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer , 2007, International journal of cancer.

[4]  T. Young,et al.  Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[5]  M. Türk,et al.  Smart and cationic poly(NIPA)/PEI block copolymers as non‐viral vectors: in vitro and in vivo transfection studies , 2007, Journal of tissue engineering and regenerative medicine.

[6]  N. Rapoport Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery , 2007 .

[7]  C. van Nostrum,et al.  Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: an attractive tool for drug delivery. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[8]  J. Santamaría,et al.  Magnetic nanoparticles for drug delivery , 2007 .

[9]  Z. Duan,et al.  Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer. , 2007, Cancer research.

[10]  Ernst Wagner,et al.  Programmed drug delivery: nanosystems for tumor targeting , 2007, Expert opinion on biological therapy.

[11]  Shirui Mao,et al.  Crosslinked nanocarriers based upon poly(ethylene imine) for systemic plasmid delivery: in vitro characterization and in vivo studies in mice. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[12]  S. Kawakami,et al.  Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[13]  M. Amiji,et al.  Poly(ethylene glycol)-modified thiolated gelatin nanoparticles for glutathione-responsive intracellular DNA delivery. , 2007, Nanomedicine : nanotechnology, biology, and medicine.

[14]  Y. Tong,et al.  Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anticancer drugs. , 2007, Biomaterials.

[15]  Ick Chan Kwon,et al.  pH- and temperature-sensitive, injectable, biodegradable block copolymer hydrogels as carriers for paclitaxel. , 2007, International journal of pharmaceutics.

[16]  Ajay Kumar Gupta,et al.  Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. , 2007, Nanomedicine.

[17]  Vladimir P Torchilin,et al.  Enhanced transfection of tumor cells in vivo using “Smart” pH-sensitive TAT-modified pegylated liposomes , 2007, Journal of drug targeting.

[18]  Vladimir P Torchilin,et al.  Antinucleosome Antibody-Modified Liposomes and Lipid-Core Micelles for Tumor-Targeted Delivery of Therapeutic and Diagnostic Agents , 2007, Journal of liposome research.

[19]  K. Kang,et al.  Application of novel metal nanoparticles as optical/thermal agents in optical mammography and hyperthermic treatment for breast cancer. , 2007, Advances in experimental medicine and biology.

[20]  I. Bravo-Osuna,et al.  Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system. , 2007, Biomaterials.

[21]  R. Langer,et al.  Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model , 2007, Cancer Chemotherapy and Pharmacology.

[22]  Bhawna Gupta,et al.  Monoclonal antibody 2C5-modified doxorubicin-loaded liposomes with significantly enhanced therapeutic activity against intracranial human brain U-87 MG tumor xenografts in nude mice , 2007, Cancer Immunology, Immunotherapy.

[23]  Paula Gould,et al.  NANOMAGNETISM SHOWS IN VIVO POTENTIAL , 2006 .

[24]  M. Ogris,et al.  Reversibly stable thiopolyplexes for intracellular delivery of genes. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[25]  W. Arap,et al.  Display technologies: Application for the discovery of drug and gene delivery agents , 2006, Advanced Drug Delivery Reviews.

[26]  Jia-cong Shen,et al.  The development and characterization of a glutathione-sensitive cross-linked polyethylenimine gene vector. , 2006, Biomaterials.

[27]  Vladimir P Torchilin,et al.  Recent approaches to intracellular delivery of drugs and DNA and organelle targeting. , 2006, Annual review of biomedical engineering.

[28]  Jia-Ling Yang,et al.  Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery. , 2006, International journal of pharmaceutics.

[29]  U. Nielsen,et al.  Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. , 2006, Cancer research.

[30]  P. Couvreur,et al.  Nanotechnology: Intelligent Design to Treat Complex Disease , 2006, Pharmaceutical Research.

[31]  Yuhan Lee,et al.  Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[32]  I. Buchan,et al.  Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. , 2006, JAMA.

[33]  Robert Langer,et al.  Nanoparticle–aptamer bioconjugates for cancer targeting , 2006, Expert opinion on drug delivery.

[34]  H. Shmeeda,et al.  Reduced Toxicity and Superior Therapeutic Activity of a Mitomycin C Lipid-Based Prodrug Incorporated in Pegylated Liposomes , 2006, Clinical Cancer Research.

[35]  V. Torchilin,et al.  Transactivating transcriptional activator-mediated drug delivery , 2006, Expert opinion on drug delivery.

[36]  Sung Wan Kim,et al.  Novel pH sensitive block copolymer micelles for solvent free drug loading. , 2006, Macromolecular bioscience.

[37]  Kwang Hee Lee,et al.  Biodegradable thermo-sensitive nanoparticles from poly(L-lactic acid)/poly(ethylene glycol) alternating multi-block copolymer for potential anti-cancer drug carrier. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[38]  M. Dewhirst,et al.  Hyperthermia mediated liposomal drug delivery , 2006, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[39]  J. Dobson Magnetic nanoparticles for drug delivery , 2006 .

[40]  Ho-Suk Choi,et al.  Doxorubicin-encapsulated thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-acrylamide): drug release behavior and stability in the presence of serum. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[41]  V. Torchilin Multifunctional nanocarriers. , 2006, Advanced drug delivery reviews.

[42]  Zeljko Vujaskovic,et al.  Re-setting the biologic rationale for thermal therapy , 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[43]  S. B. Tiwari,et al.  Long-Circulating Polymeric Nanovectors for Tumor-Selective Gene Delivery , 2005, Technology in cancer research & treatment.

[44]  C. Alexander,et al.  Thermoresponsive polymers as gene delivery vectors: cell viability, DNA transport and transfection studies. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[45]  R. Langer,et al.  Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies , 2005, Pharmaceutical Research.

[46]  H. Hui,et al.  Thermo- and pH-sensitive dendrimer derivatives with a shell of poly(N,N-dimethylaminoethyl methacrylate) and study of their controlled drug release behavior , 2005 .

[47]  M. Türk,et al.  Intelligent polymers as nonviral vectors , 2005, Gene Therapy.

[48]  Yasuo Shinohara,et al.  Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy. , 2005, International journal of pharmaceutics.

[49]  S. Goldberg,et al.  Combined radiofrequency ablation and adjuvant liposomal chemotherapy: effect of chemotherapeutic agent, nanoparticle size, and circulation time. , 2005, Journal of vascular and interventional radiology : JVIR.

[50]  M. Amiji,et al.  Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione. , 2005, Bioconjugate chemistry.

[51]  Kazunori Kataoka,et al.  Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. , 2005, Molecular bioSystems.

[52]  S. Otto,et al.  Reversible covalent chemistry in drug delivery. , 2005, Current drug discovery technologies.

[53]  Mansoor Amiji,et al.  Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. , 2005, Molecular pharmaceutics.

[54]  A. Hoffman,et al.  'Smart' delivery systems for biomolecular therapeutics. , 2005, Orthodontics & craniofacial research.

[55]  E. Pişkin Stimuli-responsive polymers in gene delivery , 2005, Expert review of medical devices.

[56]  Hiroyuki Honda,et al.  Medical application of functionalized magnetic nanoparticles. , 2005, Journal of bioscience and bioengineering.

[57]  S. Sahoo,et al.  Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. , 2005, Molecular pharmaceutics.

[58]  Mansoor Amiji,et al.  Tumor-Targeted Gene Delivery Using Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles: In Vitro and in Vivo Studies , 2005, Pharmaceutical Research.

[59]  M. Amiji,et al.  Poly(ethylene oxide)-modified poly(ɛ-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer , 2005 .

[60]  F. Szoka,et al.  Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[61]  A. C. Hunter,et al.  Nanomedicine: current status and future prospects , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[62]  V. Torchilin Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[63]  You Han Bae,et al.  Super pH-sensitive multifunctional polymeric micelle. , 2005, Nano letters.

[64]  H. Fain,et al.  Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[65]  Kazunori Kataoka,et al.  Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. , 2005, Bioconjugate chemistry.

[66]  Mansoor Amiji,et al.  Cellular interactions and in vitro DNA transfection studies with poly(ethylene glycol)-modified gelatin nanoparticles. , 2005, Journal of pharmaceutical sciences.

[67]  Jean-Christophe Leroux,et al.  Report on the use of poly(organophosphazenes) for the design of stimuli-responsive vesicles. , 2004, Biomacromolecules.

[68]  H. Schluesener,et al.  Selection of recombinant phages binding to pathological endothelial and tumor cells of rat glioblastoma by in-vivo display , 2004, Journal of the Neurological Sciences.

[69]  J. Fréchet,et al.  Stimuli-responsive supramolecular assemblies of linear-dendritic copolymers. , 2004, Journal of the American Chemical Society.

[70]  K. Ulbrich,et al.  Antibody-targeted Polymer–doxorubicin Conjugates with pH-controlled Activation , 2004, Journal of drug targeting.

[71]  S. Briggs,et al.  Increased Resistance of DNA Lipoplexes to Protein Binding In Vitro by Surface-modification with a Multivalent Hydrophilic Polymer , 2004, Journal of drug targeting.

[72]  David Cunliffe,et al.  Thermo and pH responsive polymers as gene delivery vectors: effect of polymer architecture on DNA complexation in vitro. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[73]  N. Rapoport Combined cancer therapy by micellar-encapsulated drug and ultrasound. , 2004, International journal of pharmaceutics.

[74]  J. Leroux,et al.  Preparation and characterization of water-soluble pH-sensitive nanocarriers for drug delivery. , 2004, International journal of pharmaceutics.

[75]  M. Türk,et al.  In vitro transfection of HeLa cells with temperature sensitive polycationic copolymers. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[76]  Kazuo Maruyama,et al.  Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system. , 2004, Biochemistry.

[77]  P. Couvreur,et al.  "Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes. , 2004, Advanced drug delivery reviews.

[78]  Sérgio Simões,et al.  On the formulation of pH-sensitive liposomes with long circulation times. , 2004, Advanced drug delivery reviews.

[79]  Y. Yoshioka,et al.  Design of a pH-Sensitive Polymeric Carrier for Drug Release and Its Application in Cancer Therapy , 2004, Clinical Cancer Research.

[80]  P. Cullis,et al.  Drug Delivery Systems: Entering the Mainstream , 2004, Science.

[81]  K. Ulbrich,et al.  Polymer‐coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction , 2004, The journal of gene medicine.

[82]  J. Benoit,et al.  Serum-stable and long-circulating, PEGylated, pH-sensitive liposomes. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[83]  M. Türk,et al.  Gene delivery: intelligent but just at the beginning , 2004, Journal of biomaterials science. Polymer edition.

[84]  Jean M. J. Fréchet,et al.  Development of acid-sensitive copolymer micelles for drug delivery , 2004 .

[85]  Mansoor Amiji,et al.  Long-Circulating Poly(Ethylene Glycol)-Modified Gelatin Nanoparticles for Intracellular Delivery , 2002, Pharmaceutical Research.

[86]  C. Anthony Hunt,et al.  Engineering Targeted In Vivo Drug Delivery. I. The Physiological and Physicochemical Principles Governing Opportunities and Limitations , 2004, Pharmaceutical Research.

[87]  Allan Hoffman,et al.  A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[88]  S. Brocchini,et al.  Polyacetal-doxorubicin conjugates designed for pH-dependent degradation. , 2003, Bioconjugate chemistry.

[89]  Kam W Leong,et al.  Thermally responsive polymeric micellar nanoparticles self-assembled from cholesteryl end-capped random poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): synthesis, temperature-sensitivity, and morphologies. , 2003, Journal of colloid and interface science.

[90]  You Han Bae,et al.  Polymeric micelle for tumor pH and folate-mediated targeting. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[91]  S. Hui,et al.  Localized delivery to CT-26 tumors in mice using thermosensitive liposomes. , 2003, International journal of pharmaceutics.

[92]  Hyun Joon Shin,et al.  Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[93]  M. Johansson,et al.  Cell surface adherence and endocytosis of protein transduction domains. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

[94]  Jean Campbell,et al.  Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[95]  S. Armes,et al.  Synthesis and Aqueous Solution Behavior of a pH-Responsive Schizophrenic Diblock Copolymer , 2003 .

[96]  Eun Seong Lee,et al.  Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[97]  Joel A Swanson,et al.  Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities. , 2003, Advanced drug delivery reviews.

[98]  S. W. Kim,et al.  Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics , 2002 .

[99]  F. Szoka,et al.  Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization. , 2002, Bioconjugate chemistry.

[100]  K. Kono,et al.  Effect of poly(ethylene glycol) grafts on temperature-sensitivity of thermosensitive polymer-modified liposomes. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[101]  Ernst Wagner,et al.  Targeting tumors with non-viral gene delivery systems. , 2002, Drug discovery today.

[102]  M. Yokoyama Gene delivery using temperature-responsive polymeric carriers. , 2002, Drug discovery today.

[103]  V. Lenaerts,et al.  Optimizing pH-responsive Polymeric Micelles for Drug Delivery in a Cancer Photodynamic Therapy Model , 2002, Journal of drug targeting.

[104]  G. Molineux Pegylation: engineering improved pharmaceuticals for enhanced therapy. , 2002, Cancer treatment reviews.

[105]  K. Kono,et al.  Thermosensitive polymer-modified liposomes. , 2001, Advanced drug delivery reviews.

[106]  T. Ishida,et al.  Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells. , 2001, Biochimica et biophysica acta.

[107]  S. Hui,et al.  Temperature-controlled content release from liposomes encapsulating Pluronic F127. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[108]  M. Dewhirst,et al.  Drug targeting using thermally responsive polymers and local hyperthermia. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[109]  V. Torchilin,et al.  Drug and DNA delivery to mitochondria. , 2001, Advanced drug delivery reviews.

[110]  E. Wagner,et al.  Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. , 2001, Bioconjugate chemistry.

[111]  Freya Q. Schafer,et al.  Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. , 2001, Free radical biology & medicine.

[112]  E. Roux,et al.  N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[113]  D. Tomalia,et al.  Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. , 2001, Drug discovery today.

[114]  Martin L Read,et al.  Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene therapy. , 2001, Blood.

[115]  E. Snyder,et al.  Protein/peptide transduction domains: potential to deliver large DNA molecules into cells. , 2001, Current opinion in molecular therapeutics.

[116]  K. Kataoka,et al.  Block copolymer micelles for drug delivery: design, characterization and biological significance. , 2001, Advanced drug delivery reviews.

[117]  O. Danos,et al.  Polyethylenimine‐mediated gene delivery: a mechanistic study , 2001, The journal of gene medicine.

[118]  S. Armes,et al.  The remarkable `flip-flop' self assembly of a diblock copolymer in aqueous solution. , 2001 .

[119]  L. Seymour,et al.  Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo , 2001, Gene Therapy.

[120]  M. Dewhirst,et al.  Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. , 2000, Cancer research.

[121]  I. Niculescu-Duvaz Technology evaluation: gemtuzumab ozogamicin, Celltech Group. , 2000, Current opinion in molecular therapeutics.

[122]  G. Schoehn,et al.  Lipoic acid-derived amphiphiles for redox-controlled DNA delivery. , 2000, Chemistry & biology.

[123]  S. W. Kim,et al.  pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer. , 2000, Bioconjugate chemistry.

[124]  Hongwei Shen,et al.  Control of Architecture in Block‐Copolymer Vesicles , 2000 .

[125]  Y. M. Lee,et al.  Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(epsilon-caprolactone) (PCL) amphiphilic block copolymeric nanospheres. II. Thermo-responsive drug release behaviors. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[126]  T. Okano,et al.  Inner core segment design for drug delivery control of thermo-responsive polymeric micelles. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[127]  T. Okano,et al.  Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[128]  K. Ulbrich,et al.  Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[129]  K. Ulbrich,et al.  Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab')(2)-targeted conjugates and combined therapy with immunomodulators. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[130]  J. Taillefer,et al.  Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs. , 2000, Journal of pharmaceutical sciences.

[131]  T. Okano,et al.  Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate). , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[132]  K. Kono,et al.  Temperature‐dependent interaction of thermo‐sensitive polymer‐modified liposomes with CV1 cells , 1999, FEBS letters.

[133]  D. Carlo,et al.  Stabilization of poly-L-lysine/DNA polyplexes for in vivo gene delivery to the liver. , 1999, Biochimica et biophysica acta.

[134]  K. Kono,et al.  Thermosensitive polymer-modified liposomes that release contents around physiological temperature. , 1999, Biochimica et biophysica acta.

[135]  J. Drevs,et al.  In Vivo and In Vitro Efficacy of an Acid-Sensitive Albumin Conjugate of Adriamycin Compared to the Parent Compound in Murine Renal-Cell Carcinoma , 1999 .

[136]  T. Kasama,et al.  Analysis of glycosphingolipids of human head and neck carcinomas with comparison to normal tissue , 1998, Biochemistry and molecular biology international.

[137]  C. Unger,et al.  Synthesis and in vitro efficacy of transferrin conjugates of the anticancer drug chlorambucil. , 1998, Journal of medicinal chemistry.

[138]  P. Low,et al.  The Effects of pH and Intraliposomal Buffer Strength on the Rate of Liposome Content Release and Intracellular Drug Delivery , 1998, Bioscience reports.

[139]  F Lechenault,et al.  Transferrin conjugates of doxorubicin: synthesis, characterization, cellular uptake, and in vitro efficacy. , 1998, Journal of pharmaceutical sciences.

[140]  P. Low,et al.  Folate-mediated targeting of therapeutic and imaging agents to cancers. , 1998, Critical reviews in therapeutic drug carrier systems.

[141]  S. Davis,et al.  Biomedical applications of nanotechnology--implications for drug targeting and gene therapy. , 1997, Trends in biotechnology.

[142]  C. Malvy,et al.  pH-Sensitive Liposomes: An Intelligent System for the Delivery of Antisense Oligonucleotides , 1997 .

[143]  Teruo Okano,et al.  Polymeric micelles as new drug carriers , 1996 .

[144]  Samuel Zalipsky,et al.  Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol) , 1996, FEBS letters.

[145]  K. Kono,et al.  Temperature-controlled release property of phospholipid vesicles bearing a thermo-sensitive polymer. , 1996, Biochimica et biophysica acta.

[146]  L. Gerweck,et al.  Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. , 1996, Cancer research.

[147]  J. Leiden Gene therapy--promise, pitfalls, and prognosis. , 1995, The New England journal of medicine.

[148]  T. Okano,et al.  Comb-type grafted hydrogels with rapid deswelling response to temperature changes , 1995, Nature.

[149]  P. Low,et al.  Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro. , 1995, Biochimica et biophysica acta.

[150]  J. Ross,et al.  Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications , 1994, Cancer.

[151]  Y. Bae,et al.  pH/temperature-sensitive polymers for macromolecular drug loading and release , 1994 .

[152]  Sydney S. Weinstein,et al.  Flip/flop , 1993 .

[153]  L. Huang,et al.  Phosphatidylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications. , 1992, Biochimica et biophysica acta.

[154]  H. G. Schild Poly(N-isopropylacrylamide): experiment, theory and application , 1992 .

[155]  E. Unanue,et al.  Reduction of disulfide bonds within lysosomes is a key step in antigen processing. , 1991, Journal of immunology.

[156]  Herbert H. Hooper,et al.  SWELLING EQUILIBRIA FOR WEAKLY IONIZABLE, TEMPERATURE-SENSITIVE HYDROGELS , 1991 .

[157]  P. Okunieff,et al.  Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. , 1989, Cancer research.

[158]  L. Huang,et al.  Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes. , 1989, Biochemistry.

[159]  H. Maeda,et al.  Tumoritropic and lymphotropic principles of macromolecular drugs. , 1989, Critical reviews in therapeutic drug carrier systems.

[160]  N. Bodor,et al.  Evidence for suppression of serum LH without elevation in serum estradiol or prolactin with a brain-enhanced redox delivery system for estradiol. , 1988, Life sciences.

[161]  H. Maeda,et al.  Anticancer effects of arterial administration of the anticancer agent SMANCS with lipiodol on metastatic lymph nodes , 1987, Cancer.

[162]  L. Huang,et al.  pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs. , 1986, Cancer research.

[163]  P. Spiller,et al.  Blood flow. , 1985, European heart journal.

[164]  R. Lenkinski,et al.  A nuclear magnetic resonance study of the self-association of adriamycin and daunomycin in aqueous solution , 1985 .

[165]  James R. Dewald,et al.  A New Class of Polymers: Starburst-Dendritic Macromolecules , 1985 .

[166]  J. Haveman,et al.  The relevance of tumour pH to the treatment of malignant disease. , 1984, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[167]  F. Szoka,et al.  pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. , 1984, Biochemistry.

[168]  E. Simpson,et al.  Cholesterol metabolism in cancer cells in monolayer culture. VI. Metabolism of high-density lipoprotein. , 1982, Archives of biochemistry and biophysics.

[169]  E. Simpson,et al.  Cholesterol metabolism in cancer cells in monolayer culture. III. Low‐density lipoprotein metabolism , 1981, International journal of cancer.

[170]  R Blumenthal,et al.  Design of liposomes for enhanced local release of drugs by hyperthermia. , 1978, Science.

[171]  M. Heskins,et al.  Solution Properties of Poly(N-isopropylacrylamide) , 1968 .

[172]  I. A. Rose Glutathione , 1960, Nature.