Amyotrophic lateral sclerosis (ALS).

ALS symptoms vary from one person to another according to which group of muscles is affected by the disease. Tripping, dropping things, abnormal fatigue in the arms and/or legs, slurred speech, difficulty in talking loudly, uncontrollable bouts of laughing or crying, and muscle cramps and twitches are all symptoms of ALS. ALS usually starts first in the hands and will cause problems in dressing, bathing, or other simple tasks. It may progress to more on one side of the body and generally proceeds up the arm or leg. If it starts in the feet, walking will become difficult. ALS can also start in the throat, causing difficulty with swallowing.