Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1.
暂无分享,去创建一个
M. Imamura | D. Ito | K. Kami | M. Koizumi | Tomohiko Mori | E. Toyoda | K. Fujimoto | R. Doi | Y. Kawaguchi | G. Gittes
[1] M. Imamura,et al. Chronic exposure of transforming growth factor beta 1 confers a more aggressive tumor phenotype through downregulation of p21(WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells. , 2004, Surgery.
[2] M. Imamura,et al. Conditional transformation of mouse pancreatic epithelial cells: an in vitro model for analysis of genetic events in pancreatocarcinogenesis. , 2004, Biochemical and biophysical research communications.
[3] Douglas A. Melton,et al. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation , 2004, Nature.
[4] M. Imamura,et al. Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer. , 2003, Surgery.
[5] I. Fidler,et al. Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis. , 2003, Cancer research.
[6] M. Hussain,et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion , 2003 .
[7] J. Slack,et al. Experimental Conversion of Liver to Pancreas , 2003, Current Biology.
[8] Michael B Wheeler,et al. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. , 2002, Diabetes.
[9] Jie Zhou,et al. Exendin‐4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX‐1 and HNF3β transcription factors , 2002, Journal of cellular physiology.
[10] T. Miyatsuka,et al. PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. , 2002, Diabetes.
[11] Jie Zhou,et al. Glucagon-Like Peptide-1 Causes Pancreatic Duodenal Homeobox-1 Protein Translocation from the Cytoplasm to the Nucleus of Pancreatic β-Cells by a Cyclic Adenosine Monophosphate/Protein Kinase A-Dependent Mechanism. , 2001, Endocrinology.
[12] R. McKay,et al. Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets , 2001, Science.
[13] C. Wright,et al. Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. , 2001, Diabetes.
[14] D. Drucker,et al. Minireview: the glucagon-like peptides. , 2001, Endocrinology.
[15] R. Whitehead,et al. Conditionally immortalized mouse hepatocytes for use in liver gene therapy , 2000, Journal of gastroenterology and hepatology.
[16] S. Bonner-Weir,et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. , 2000, Diabetes.
[17] Jie Zhou,et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. , 1999, Diabetes.
[18] Jie Zhou,et al. Glucagon-Like Peptide-1 Regulates the Beta Cell Transcription Factor, PDX-1, in Insulinoma Cells. , 1999, Endocrinology.
[19] M. Prentki,et al. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells , 1999, Diabetologia.
[20] M. Noble,et al. Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties. , 1995, Circulation.
[21] H. Edlund,et al. Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.
[22] M. Noble,et al. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.