Induction of retinal‐dependent calcium influx in human melanocytes by UVA or UVB radiation contributes to the stimulation of melanosome transfer

The transfer of melanosomes from melanocytes to neighbouring keratinocytes is critical to protect the skin from the deleterious effects of ultraviolet A (UVA) and ultraviolet B (UVB) irradiation; however, the initial factor(s) that stimulates melanosome transfer remains unclear. In this study, we investigated the induction of retinal‐dependent calcium (Ca2+) influx in melanocytes (MCs) by UVA or UVB irradiation and the effect of transient receptor potential cation channel subfamily M member 1 (TRPM1) (melastatin1)‐related Ca2+ influx on melanosome transfer.

[1]  J. Lehmann,et al.  Photocarcinogenesis and Skin Cancer Prevention Strategies. , 2016, Anticancer research.

[2]  V. Hearing,et al.  Photobiological implications of melanin photoprotection after UVB‐induced tanning of human skin but not UVA‐induced tanning , 2015, Pigment cell & melanoma research.

[3]  R. Halaban,et al.  Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure , 2015, Science.

[4]  R. Duvoisin,et al.  Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels. , 2015, Investigative ophthalmology & visual science.

[5]  E. Oancea,et al.  Opsin Expression in Human Epidermal Skin , 2014, Photochemistry and photobiology.

[6]  J. Brissette,et al.  Skin as a living coloring book: how epithelial cells create patterns of pigmentation , 2014, Pigment cell & melanoma research.

[7]  J. Hammer,et al.  Melanosome transfer: it is best to give and receive. , 2014, Current opinion in cell biology.

[8]  I. Han,et al.  Keratinocyte-derived Laminin-332 Protein Promotes Melanin Synthesis via Regulation of Tyrosine Uptake* , 2014, The Journal of Biological Chemistry.

[9]  E. Oancea,et al.  UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes , 2014, The Journal of general physiology.

[10]  L. Hudson,et al.  Melanocytes and keratinocytes have distinct and shared responses to ultraviolet radiation and arsenic. , 2014, Toxicology letters.

[11]  E. Entcheva,et al.  Optogenetic control of cardiomyocytes via viral delivery. , 2014, Methods in molecular biology.

[12]  Yan Sun,et al.  Opsin3 sensitizes hepatocellular carcinoma cells to 5-fluorouracil treatment by regulating the apoptotic pathway. , 2012, Cancer letters.

[13]  M. Ichihashi,et al.  Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion. , 2012, The Journal of investigative dermatology.

[14]  Dong-Seok Kim,et al.  A Simple Assay Method for Melanosome Transfer , 2012, Annals of dermatology.

[15]  M. Tucker,et al.  Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment , 2012, Nature Communications.

[16]  E. Oancea,et al.  UVA Phototransduction Drives Early Melanin Synthesis in Human Melanocytes , 2011, Current Biology.

[17]  Junzo Kinoshita,et al.  Mechanism of voriconazole-induced transient visual disturbance: reversible dysfunction of retinal ON-bipolar cells in monkeys. , 2011, Investigative ophthalmology & visual science.

[18]  V. Hearing,et al.  The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin , 2011, Pigment cell & melanoma research.

[19]  V. Hearing,et al.  Update on the regulation of mammalian melanocyte function and skin pigmentation. , 2011, Expert review of dermatology.

[20]  W. Reinhold,et al.  Regulation of human skin pigmentation in situ by repetitive UV exposure: molecular characterization of responses to UVA and/or UVB. , 2010, The Journal of investigative dermatology.

[21]  Dong-guang Li,et al.  Efficacy of quantifying melanosome transfer with flow cytometry in a human melanocyte–HaCaT keratinocyte co‐culture system in vitro , 2009, Experimental dermatology.

[22]  C. Weber,et al.  Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light. , 2009, American journal of physiology. Cell physiology.

[23]  D. Clapham,et al.  TRPM1 Forms Ion Channels Associated with Melanin Content in Melanocytes , 2009, Science Signaling.

[24]  L. Marrot,et al.  Skin DNA photodamage and its biological consequences. , 2008, Journal of the American Academy of Dermatology.

[25]  V. Hearing,et al.  The Protective Role of Melanin Against UV Damage in Human Skin † , 2008, Photochemistry and photobiology.

[26]  M. Yaar,et al.  Keratin 16 Expression in Epidermal Melanocytes of Normal Human Skin , 2005, The American Journal of dermatopathology.

[27]  K. Maeda,et al.  Involvement of photooxidation of melanogenic precursors in prolonged pigmentation induced by ultraviolet A. , 2004, The Journal of investigative dermatology.

[28]  V. Hearing,et al.  A melanocyte-keratinocyte coculture model to assess regulators of pigmentation in vitro. , 2002, Analytical biochemistry.

[29]  H. Hönigsmann,et al.  Erythema and pigmentation , 2002, Photodermatology, photoimmunology & photomedicine.

[30]  G. Scott,et al.  Protease-activated receptor 2, a receptor involved in melanosome transfer, is upregulated in human skin by ultraviolet irradiation. , 2001, The Journal of investigative dermatology.

[31]  V. Virador,et al.  Effects of all-trans retinoic acid on melanogenesis in pigmented skin equivalents and monolayer culture of melanocytes. , 2001, Journal of dermatological science.

[32]  W. Cunliffe,et al.  Biosynthesis of 3,4-didehydroretinol from retinol by human skin keratinocytes in culture. , 1993, The Biochemical journal.