Compartment boundaries: at the edge of development.

Compartment boundaries have fascinated biologists for more than 25 years. We now know that these boundaries play important roles in pattern formation, yet how these boundaries are established during development remained a mystery. Here, we describe the exciting progress that has been made recently towards elucidating the mechanisms of boundary formation.

[1]  T. Tabata,et al.  Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs , 1994, Cell.

[2]  A. Joyner,et al.  Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum. , 1991, Development.

[3]  A. Fausto-Sterling,et al.  In vitro culture of Drosophila imaginal disc cells: aggregation, sorting out, and differentiative abilities. , 1987, Developmental biology.

[4]  A. Lumsden,et al.  Segregation of Rhombomeres by Differential Chemoaffinity , 1997, Molecular and Cellular Neuroscience.

[5]  C Irving,et al.  Cell-cell interactions and segmentation in the developing vertebrate hindbrain. , 1996, Biochemical Society symposium.

[6]  Peter A Lawrence,et al.  Morphogens, Compartments, and Pattern: Lessons from Drosophila? , 1996, Cell.

[7]  D. Wilkinson.  Genetic control of segmentation in the vertebrate hindbrain. , 1995, Perspectives on developmental neurobiology.

[8]  A. Nose,et al.  A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos , 1986, The Journal of cell biology.

[9]  P. Lawrence,et al.  Further studies of the engrailed phenotype in Drosophila. , 1982, The EMBO journal.

[10]  Konrad Basler,et al.  Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein , 1994, Nature.

[11]  T. Tabata,et al.  The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. , 1992, Genes & development.

[12]  A. Garcı́a-Bellido.  Changes in selective affinity following transdetermination in imaginal disc cells of Drosophila melanogaster. , 1966, Experimental cell research.

[13]  J G Flanagan,et al.  The ephrins and Eph receptors in neural development. , 1998, Annual review of neuroscience.

[14]  S. Carroll,et al.  Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions. , 1993, Development.

[15]  G. Struhl,et al.  Direct and Long-Range Action of a Wingless Morphogen Gradient , 1996, Cell.

[16]  G. Morata,et al.  Developmental compartmentalisation of the wing disk of Drosophila. , 1973, Nature: New biology.

[17]  P. Lawrence,et al.  Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen. , 1997, Development.

[18]  P. O’Farrell,et al.  The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression , 1985, Cell.

[19]  G. Edelman,et al.  Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Blair,et al.  Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. , 1997, Development.

[21]  H. Ursprung,et al.  The Biology of Imaginal Disks , 1972, Results and Problems in Cell Differentiation.

[22]  M. Dominguez,et al.  A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye , 1998, Nature.

[23]  Malcolm S. Steinberg,et al.  Reconstruction of Tissues by Dissociated Cells , 1963 .

[24]  Y. Jan,et al.  Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. , 1996, Genes & development.

[25]  S. Cohen,et al.  Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila , 1993, Cell.

[26]  S. Fraser,et al.  Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions , 1990, Nature.

[27]  C. Neumann,et al.  Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. , 1997, Development.

[28]  P. Lawrence.  Compartments in vertebrates? , 1990, Nature.

[29]  M. Takeichi,et al.  Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[30]  S. Cohen,et al.  Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing , 1996, Nature.

[31]  P. Lawrence,et al.  Control of compartment development by the engrailed gene in Drosophila , 1975, Nature.

[32]  D. Wilkinson,et al.  Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. , 1995, Development.

[33]  D. St Johnston,et al.  Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis. , 1998, Development.

[34]  D. Wilkinson,et al.  In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins , 1999, Nature.

[35]  G. Struhl,et al.  Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. , 1995, Development.

[36]  B. Lewin.  The Mystique of Epigenetics , 1998, Cell.

[37]  Konrad Basler,et al.  Control of compartmental affinity boundaries by Hedgehog , 1997, Nature.

[38]  Akinao Nose,et al.  Expressed recombinant cadherins mediate cell sorting in model systems , 1988, Cell.

[39]  Wolfgang Wurst,et al.  The mouse Engrailed-1 gene and ventral limb patterning , 1996, Nature.

[40]  S. Carroll,et al.  Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing , 1995, Cell.

[41]  John B. Thomas,et al.  The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. , 1994, Development.

[42]  Philip L. Townes,et al.  Directed movements and selective adhesion of embryonic amphibian cells , 1955 .

[43]  J. Clarke,et al.  Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb. , 1997, Development.

[44]  G. Struhl,et al.  Direct and Long-Range Action of a DPP Morphogen Gradient , 1996, Cell.

[45]  V. Prince,et al.  Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts. , 1993, Development.

[46]  W. Gelbart,et al.  A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family , 1987, Nature.

[47]  Qiling Xu,et al.  Eph receptors and ephrins restrict cell intermingling and communication , 1999, Nature.

[48]  Ulrich Tepass,et al.  Drosophila oocyte localization is mediated by differential cadherin-based adhesion , 1998, Nature.

[49]  M. Takeichi,et al.  Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos. , 1987, Developmental biology.

[50]  S. Blair.  Mechanisms of compartment formation: evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila. , 1993, Development.

[51]  M. Takeichi,et al.  Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development , 1986, Nature.

[52]  A. Garcı́a-Bellido,et al.  Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. , 1996, Development.

[53]  F. Díaz-Benjumea,et al.  Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. , 1995, Development.