Peptides Regulate Cortical Thymocytes Differentiation, Proliferation, and Apoptosis

The processes of differentiation, proliferation, and apoptosis were studied in a cell culture of human cortical thymocytes under the influence of short peptides T-32 (Glu-Asp-Ala) and T-38 (Lys-Glu-Asp). Peptides T-32 and T-38 amplified cortical thymocytes differentiation towards regulatory T cells, increased their proliferative activity, and decreased the level of apoptosis. Moreover, peptides under study stimulated proliferative and antiapoptotic activity of the mature regulatory T cells.

[1]  V. Khavinson,et al.  Morphofunctional fundamentals for peptide regulation of aging , 2011, Biology Bulletin Reviews.

[2]  R. Kominami,et al.  Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus. , 2010, International journal of radiation oncology, biology, physics.

[3]  V. Anisimov,et al.  Peptide bioregulation of aging: results and prospects , 2010, Biogerontology (Dordrecht).

[4]  V. Polyakova,et al.  Age-related differences in expression of signal differentiation factors for human thymic epithelial cells , 2007, Bulletin of Experimental Biology and Medicine.

[5]  G. Sukhikh,et al.  Expression of regulatory T-lymphocyte phenotype in human fetal hemopoietic and lymphoid cell culture , 2006, Bulletin of Experimental Biology and Medicine.

[6]  V. Khavinson,et al.  Gerontological Aspects of Genome Peptide Regulation , 2005 .

[7]  I. M. Belyakov,et al.  Cytokines in the thymus: production and biological effects. , 2004, Current medicinal chemistry.

[8]  V. Khavinson,et al.  Role of Aqueous Medium in Mechanisms Underlying the Influence of Immunoactive Peptides in Ultralow Doses , 2003, Bulletin of Experimental Biology and Medicine.

[9]  V. Yuzhakov,et al.  Hormonal function and proliferative activity of thymic cells in humans: immunocytochemical correlations. , 2003, Neuro endocrinology letters.

[10]  V. Khavinson,et al.  Peptides of pineal gland and thymus prolong human life. , 2003, Neuro endocrinology letters.

[11]  V. Khavinson,et al.  Diffuse neuroendocrine system and mitochondrial diseases: molecular and cellular bases of pathogenesis, new approaches to diagnosis and therapy. , 2000, Neuro endocrinology letters.