Healthcare Chip Based on Integrated Electrochemical Sensors Used for Clinical Diagnostics of Bun

Research based on health marker sensors, such as Na+, glucose, K+ have been carried out using integrated ISE (ion selectivity electrode). In this study, focus has been placed on potentiometric measurement of ammonia and blood urea nitrogen (BUN) sensors using new 19-membered crown ionophore, TD19C6 (2,6,13,16,23,26-hexaoxaheptacyclo-[25.4.4.4 7,12.4 17,22.O 1,17.O 7,12.O 17.22]), poly(vinyl chloride) (PVC) membranes along with anionic additives, potassium tetrakis(4-chlorophenyl)borate (k-TCPB), sodium tetrakis(4-fluorophenyl)borate dehydrate (TFPB), and plasticizers, bis(1-butylphenyl)adipate (BBPA) and tris(2-ethylhexyl)trimellitate (TOTM). Screen-printed electrodes Ag/AgCl (250 mm in diameter) and a disposable polycarbonate chip (PC) designed using a trace amount of whole blood are also used.