Design and activity of AP endonuclease-1 inhibitors
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Zhiwei Feng | Xiang-Qun Xie | Paul A Johnston | Lirong Wang | X. Xie | P. Johnston | B. Gold | David A. Close | Zhiwei Feng | David Close | A. Srinivasan | Stanton Kochanek | LiRong Wang | Ajay Srinivasan | Abdulrahman A Almehizia | Prema Iyer | Barry Gold | Stanton J Kochanek | Prema C Iyer | A. Almehizia
[1] Laxmikant V. Kale,et al. NAMD2: Greater Scalability for Parallel Molecular Dynamics , 1999 .
[2] J. Sung,et al. Molecular and biological roles of Ape1 protein in mammalian base excision repair. , 2005, DNA repair.
[3] M. Kelley,et al. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[4] Sophia T. Mundle,et al. Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate , 2009, Biochemistry.
[5] Chang Ming Li,et al. Involvement of superoxide and nitric oxide in BRAF(V600E) inhibitor PLX4032-induced growth inhibition of melanoma cells. , 2014, Integrative biology : quantitative biosciences from nano to macro.
[6] L. Thompson,et al. Life without DNA repair. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[7] M. Kelley,et al. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. , 1997, Anticancer research.
[8] M. Kelley,et al. The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. , 2007, Molecular aspects of medicine.
[9] Alessandro Pedretti,et al. VEGA: a versatile program to convert, handle and visualize molecular structure on Windows-based PCs. , 2002, Journal of molecular graphics & modelling.
[10] Junmei Wang,et al. GPCR Structure-Based Virtual Screening Approach for CB2 Antagonist Search , 2007, J. Chem. Inf. Model..
[11] M. Berger,et al. Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[12] B. Demple,et al. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[13] M. Kelley,et al. Histology-Specific Expression of a DNA Repair Protein in Pediatric Rhabdomyosarcomas , 2001, Journal of pediatric hematology/oncology.
[14] Richard J Smeyne,et al. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[15] A. Hauschild,et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. , 2011, The New England journal of medicine.
[16] K. Bhakat,et al. Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein. , 2007, DNA repair.
[17] S. Madhusudan,et al. Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer. , 2010, Cancer treatment reviews.
[18] I. Hickson,et al. Nuclear expression of human apurinic/apyrimidinic endonuclease (HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome. , 2001, International journal of radiation oncology, biology, physics.
[19] J. Silber,et al. Synthesis and characterization of DNA minor groove binding alkylating agents. , 2013, Chemical research in toxicology.
[20] J. Tainer,et al. The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites , 1997, The EMBO journal.
[21] David M. Wilson,et al. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. , 2012, Journal of medicinal chemistry.
[22] Lirong Wang,et al. Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. , 2012, Biochemistry.
[23] David M. Wilson,et al. Impairment of APE1 Function Enhances Cellular Sensitivity to Clinically Relevant Alkylators and Antimetabolites , 2009, Molecular Cancer Research.
[24] Ajay N. Jain. Scoring noncovalent protein-ligand interactions: A continuous differentiable function tuned to compute binding affinities , 1996, J. Comput. Aided Mol. Des..
[25] T. Lindahl. Repair of intrinsic DNA lesions. , 1990, Mutation research.
[26] S. Fox,et al. Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis. , 1998, British Journal of Cancer.
[27] David M. Wilson,et al. Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1 , 2009, PloS one.
[28] T. Lindahl,et al. Rate of depurination of native deoxyribonucleic acid. , 1972, Biochemistry.
[29] M. Sternberg,et al. Isolation of a small molecule inhibitor of DNA base excision repair , 2005, Nucleic acids research.
[30] L. Dekker,et al. Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines , 2011, British Journal of Cancer.
[31] Alexander D. MacKerell,et al. All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.
[32] Peng Yang,et al. Modeling, Molecular Dynamics Simulation, and Mutation Validation for Structure of Cannabinoid Receptor 2 Based on Known Crystal Structures of GPCRs , 2014, J. Chem. Inf. Model..
[33] R. S. Coleman,et al. Effect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complex. , 2005, Biophysical journal.
[34] J. Stivers,et al. Potent Inhibition of Human Apurinic/Apyrimidinic Endonuclease 1 by Arylstibonic Acids , 2008, Molecular Pharmacology.
[35] M. Kelley,et al. Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. , 2004, Anticancer research.
[36] John E. Stone,et al. Using VMD: An Introductory Tutorial , 2008, Current protocols in bioinformatics.
[37] K. Wilson,et al. Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major. , 2007, Journal of molecular biology.
[38] S. Mitra,et al. Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells , 2008, Cell Research.
[39] Chen-Hsiang Yeang,et al. An integrated analysis of molecular aberrations in NCI-60 cell lines , 2010, BMC Bioinformatics.
[40] L. Loeb,et al. Mutagenesis by apurinic/apyrimidinic sites. , 1986, Annual review of genetics.
[41] Jan H. Jensen,et al. Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKa Values. , 2011, Journal of chemical theory and computation.
[42] M. Kelley,et al. Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). , 2010, Journal of medicinal chemistry.
[43] A. Maitra,et al. Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration , 2008, Molecular Cancer Therapeutics.
[44] Ramu Anandakrishnan,et al. H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations , 2012, Nucleic Acids Res..
[45] Chen-Hsiang Yeang,et al. Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines , 2011, BMC Systems Biology.
[46] T. Chou. Drug combination studies and their synergy quantification using the Chou-Talalay method. , 2010, Cancer research.
[47] M. Tomicic,et al. APE/Ref-1 and the mammalian response to genotoxic stress. , 2003, Toxicology.
[48] Gagandeep Kaur,et al. DNA repair and redox activities and inhibitors of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1): a comparative analysis and their scope and limitations toward anticancer drug development. , 2014, Journal of medicinal chemistry.
[49] J. Hendry,et al. Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers. , 1998, British Journal of Cancer.
[50] J. Tainer,et al. DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination , 2000, Nature.
[51] T. Darden,et al. A smooth particle mesh Ewald method , 1995 .
[52] R. Dayam,et al. Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors. , 2009, Journal of medicinal chemistry.
[53] B. Gold,et al. Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins. , 1993, Biochemistry.
[54] G. Garçon,et al. Mitochondrial oxidative stress is the achille's heel of melanoma cells resistant to Braf-mutant inhibitor , 2013, Oncotarget.
[55] Yun-Jeong Kim,et al. Overview of base excision repair biochemistry. , 2012, Current molecular pharmacology.
[56] M. Karplus,et al. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations , 1983 .