Expression of Type XXIII Collagen mRNA and Protein*

Collagen XXIII is a member of the transmembranous subfamily of collagens containing a cytoplasmic domain, a membrane-spanning hydrophobic domain, and three extracellular triple helical collagenous domains interspersed with non-collagenous domains. We cloned mouse, chicken, and humanα1(XXIII) collagen cDNAs and showed that this non-abundant collagen has a limited tissue distribution in non-tumor tissues. Lung, cornea, brain, skin, tendon, and kidney are the major sites of expression. In contrast, five transformed cell lines were tested for collagen XXIII expression, and all expressed the mRNA. In vivo the α1(XXIII) mRNA is found in mature and developing organs, the latter demonstrated using stages of embryonic chick cornea and mouse embryos. Polyclonal antibodies were generated in guinea pig and rabbit and showed that collagen XXIII has a transmembranous form and a shed form. Comparison of collagen XXIII with its closest relatives in the transmembranous subfamily of collagens, types XIII and XXV, which have the same number of triple helical and non-collagenous regions, showed that there is a discontinuity in the alignment of domains but that striking similarities remain despite this.

[1]  M. Paulsson,et al.  Collagen XXVIII, a Novel von Willebrand Factor A Domain-containing Protein with Many Imperfections in the Collagenous Domain* , 2006, Journal of Biological Chemistry.

[2]  Claus-Werner Franzke,et al.  Collagenous Transmembrane Proteins: Recent Insights into Biology and Pathology* , 2005, Journal of Biological Chemistry.

[3]  M. Bachem,et al.  Oxidized Low-Density Lipoproteins Stimulate Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Release by Coronary Smooth Muscle Cells , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[4]  R. Burgeson,et al.  A Novel Marker of Tissue Junctions, Collagen XXII* , 2004, Journal of Biological Chemistry.

[5]  S. Mundlos,et al.  Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[6]  J. Lavail,et al.  The microvesicle as a vehicle for EMMPRIN in tumor–stromal interactions , 2004, Oncogene.

[7]  D. Zillikens,et al.  The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini. , 2003, The Journal of investigative dermatology.

[8]  Fabien Calvo,et al.  Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells. , 2003, Cancer research.

[9]  R. Burgeson,et al.  Collagen XXIV, a Vertebrate Fibrillar Collagen with Structural Features of Invertebrate Collagens , 2003, Journal of Biological Chemistry.

[10]  Damien Ficheux,et al.  α-Helical Coiled-coil Oligomerization Domains Are Almost Ubiquitous in the Collagen Superfamily* , 2003, Journal of Biological Chemistry.

[11]  T. Pihlajaniemi,et al.  Type XIII Collagen and Some Other Transmembrane Collagens Contain Two Separate Coiled-coil Motifs, Which May Function as Independent Oligomerization Domains* , 2003, Journal of Biological Chemistry.

[12]  B. Zetter,et al.  Type XXIII Collagen, a New Transmembrane Collagen Identified in Metastatic Tumor Cells* , 2003, Journal of Biological Chemistry.

[13]  Paul E. Boardman,et al.  A Comprehensive Collection of Chicken cDNAs , 2002, Current Biology.

[14]  I. Kanazawa,et al.  CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC‐P/collagen type XXV , 2002, The EMBO journal.

[15]  T. Pihlajaniemi,et al.  Lack of cytosolic and transmembrane domains of type XIII collagen results in progressive myopathy. , 2001, The American journal of pathology.

[16]  T. Pihlajaniemi,et al.  Abnormal adherence junctions in the heart and reduced angiogenesis in transgenic mice overexpressing mutant type XIII collagen , 2001, The EMBO journal.

[17]  R. Burgeson,et al.  α1(XX) Collagen, a New Member of the Collagen Subfamily, Fibril-associated Collagens with Interrupted Triple Helices* , 2001, The Journal of Biological Chemistry.

[18]  K. Tasanen,et al.  Hemizygosity for a glycine substitution in collagen XVII: unfolding and degradation of the ectodomain. , 2000, The Journal of investigative dermatology.

[19]  J. Heino,et al.  Distinct Recognition of Collagen Subtypes by α1β1 and α2β1Integrins , 2000, The Journal of Biological Chemistry.

[20]  Gillian Murphy,et al.  Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signaling Pathways and Mediated by a Timp-3–Sensitive Metalloproteinase , 2000, The Journal of cell biology.

[21]  R. Burgeson,et al.  Characterization and Expression of the Laminin γ3 Chain: A Novel, Non-Basement Membrane–associated, Laminin Chain , 1999, The Journal of cell biology.

[22]  M. Bernfield,et al.  Regulated Shedding of Syndecan-1 and -4 Ectodomains by Thrombin and Growth Factor Receptor Activation* , 1997, The Journal of Biological Chemistry.

[23]  C. Gilles,et al.  Tumor Collagenase Stimulatory Factor (TCSF) Expression and Localization in Human Lung and Breast Cancers , 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[24]  S. Peltonen,et al.  Alternative splicing of mouse alpha1(XIII) collagen RNAs results in at least 17 different transcripts, predicting alpha1(XIII) collagen chains with length varying between 651 and 710 amino acid residues. , 1997, DNA and cell biology.

[25]  J. W. Foley,et al.  Temporal expression of types XII and XIV collagen mRNA and protein during avian corneal development , 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

[26]  J. R. McMillan,et al.  Mutations in the 180–kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa , 1995, Nature Genetics.

[27]  Marcel,et al.  180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa. , 1995, The Journal of clinical investigation.

[28]  H. Handa,et al.  An SV40-immortalized human corneal epithelial cell line and its characterization. , 1995, Investigative ophthalmology & visual science.

[29]  T. Pihlajaniemi,et al.  Location and alternative splicing of type XIII collagen RNA in the early human placenta. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[30]  K. Nabeshima,et al.  Enhanced expression of a tumor‐cell‐derived collagenase‐stimulatory factor in urothelial carcinoma: Its usefulness as a tumor marker for bladder cancers , 1993, International journal of cancer.

[31]  M. Boguski,et al.  dbEST — database for “expressed sequence tags” , 1993, Nature Genetics.

[32]  S. Zucker,et al.  Tumor cell-derived collagenase-stimulatory factor increases expression of interstitial collagenase, stromelysin, and 72-kDa gelatinase. , 1993, Cancer research.

[33]  T. Pihlajaniemi,et al.  Patterns of expression of the six alternatively spliced exons affecting the structures of the COL1 and NC2 domains of the alpha 1(XIII) collagen chain in human tissues and cell lines. , 1992, The Journal of biological chemistry.

[34]  L. Diaz,et al.  Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. , 1992, The Journal of investigative dermatology.

[35]  T. Pihlajaniemi,et al.  The alpha 1 chain of type XIII collagen consists of three collagenous and four noncollagenous domains, and its primary transcript undergoes complex alternative splicing. , 1990, The Journal of biological chemistry.

[36]  W. Saunders,et al.  Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome. , 1990, The Journal of clinical investigation.

[37]  I. Gipson,et al.  Reassembly of the anchoring structures of the corneal epithelium during wound repair in the rabbit. , 1989, Investigative ophthalmology & visual science.

[38]  T. Pihlajaniemi,et al.  Gene structure for the alpha 1 chain of a human short-chain collagen (type XIII) with alternatively spliced transcripts and translation termination codon at the 5' end of the last exon. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[39]  J. Seyer,et al.  Partial characterization of a low molecular weight human collagen that undergoes alternative splicing. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[40]  T. Linsenmayer,et al.  Embryonic avian cornea contains layers of collagen with greater than average stability , 1986, The Journal of cell biology.

[41]  B. Hogan,et al.  Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell ‘culture shock’ glycoprotein of Mr 43,000. , 1986, The EMBO journal.

[42]  R. Colvin,et al.  Basement membrane components in healing rabbit corneal epithelial wounds: immunofluorescence and ultrastructural studies , 1984, The Journal of cell biology.

[43]  Gregor Eichele,et al.  GenePaint.org: an atlas of gene expression patterns in the mouse embryo , 2004, Nucleic Acids Res..

[44]  J. W. Foley,et al.  Type XVII collagen (BP 180) in the developing avian cornea. , 1997, Investigative ophthalmology & visual science.

[45]  T. Pihlajaniemi,et al.  Two new collagen subgroups: membrane-associated collagens and types XV and XVII. , 1995, Progress in nucleic acid research and molecular biology.