Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities
暂无分享,去创建一个
D. Behm | R. Bentley | C. Doe | R. Willette | S. Khandekar | R. Stavenger | Dennis Lee | J. Marino | E. Hu | Zunxuan Chen | R. Kirkpatrick | E. Grygielko | Gary K. Smith | Robert P Lafferty | L. Jolivette | C. Webb | T. Yi | Terry A. Panchal | E. Dul | D. Jung | M. Bamford | L. Wright
[1] K. Dobashi,et al. Effect of Y-27632 on release of cytokines from peripheral T cells in asthmatic patients and normal subjects. , 2004, International immunopharmacology.
[2] J. Hieble,et al. Expression and functional role of Rho‐kinase in rat urinary bladder smooth muscle , 2003, British journal of pharmacology.
[3] S. Khandekar,et al. Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells. , 2006, Protein and peptide letters.
[4] Dennis Lee,et al. Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges , 2005, Expert opinion on therapeutic targets.
[5] A. Somlyo,et al. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. , 2003, Physiological reviews.
[6] W. Steers,et al. RhoA-mediated Ca2+ Sensitization in Erectile Function* , 2002, The Journal of Biological Chemistry.
[7] Dexter L. Lee,et al. Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature. , 2004, Hypertension.
[8] N. Suttorp,et al. Reduction of tumor necrosis factor-alpha (TNF-α) related nuclear factor-kappaB (NF-κB) translocation but not inhibitor kappa-B (Iκ-B)-degradation by Rho protein inhibition in human endothelial cells , 2002 .
[9] D. Hartshorne,et al. Activation of RhoA and Inhibition of Myosin Phosphatase as Important Components in Hypertension in Vascular Smooth Muscle , 2003, Circulation research.
[10] A. Takeshita,et al. Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans , 2001, Hypertension.
[11] K. Kaibuchi,et al. Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase , 1997, Science.
[12] A. Dorrance,et al. Increaseed expression of mRNA for regulator of G protein signaling domain-containing Rho guanine nucleotide exchange factors in aorta from stroke-prone spontaneously hypertensive rats. , 2004, American journal of hypertension.
[13] N. Suttorp,et al. Reduction of tumor necrosis factor-alpha (TNF-alpha) related nuclear factor-kappaB (NF-kappaB) translocation but not inhibitor kappa-B (Ikappa-B)-degradation by Rho protein inhibition in human endothelial cells. , 2002, Biochemical pharmacology.
[14] Y. Pinto,et al. Lessons from rat models of hypertension: from Goldblatt to genetic engineering. , 1998, Cardiovascular research.
[15] K. Takeda,et al. Rho-Kinase Mediates Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression in Rat Vascular Smooth Muscle Cells , 2001, Hypertension.
[16] D. Brooks,et al. Inhibition of Gene Markers of Fibrosis with a Novel Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase in Puromycin-Induced Nephritis , 2005, Journal of Pharmacology and Experimental Therapeutics.
[17] Y. Kaziro,et al. G Protein βγ Subunits Induce Stress Fiber Formation and Focal Adhesion Assembly in a Rho-dependent Manner in HeLa Cells* , 2000, The Journal of Biological Chemistry.
[18] A. Tedgui,et al. Rho-Associated Protein Kinase Contributes to Early Atherosclerotic Lesion Formation in Mice , 2003, Circulation research.
[19] A. Takeshita,et al. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[20] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[21] K. Dobashi,et al. Comparison of effects of Y-27632 and Isoproterenol on release of cytokines from human peripheral T cells. , 2003, International immunopharmacology.
[22] P. Cohen,et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. , 2000, The Biochemical journal.
[23] Y. Yoshikawa,et al. Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure. , 2003, Journal of molecular and cellular cardiology.
[24] K. Fujisawa,et al. The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. , 1996, The EMBO journal.
[25] S. Narumiya,et al. Targeted Disruption of the Mouse Rho-Associated Kinase 2 Gene Results in Intrauterine Growth Retardation and Fetal Death , 2003, Molecular and Cellular Biology.
[26] D. Behm,et al. p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 1. p38 MAPK-Dependent Endothelial Dysfunction and Hypertension , 2003, Journal of Pharmacology and Experimental Therapeutics.
[27] T. Yamamoto,et al. Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. , 1996, The EMBO journal.
[28] X. Q. Chen,et al. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton , 1996, Molecular and cellular biology.
[29] Shuh Narumiya,et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension , 1997, Nature.
[30] T. Lüscher,et al. Statin Prevents Tissue Factor Expression in Human Endothelial Cells: Role of Rho/Rho-Kinase and Akt Pathways , 2002, Circulation.
[31] Y. Kaziro,et al. G protein betagamma subunits induce stress fiber formation and focal adhesion assembly in a Rho-dependent manner in HeLa cells. , 2000, The Journal of biological chemistry.
[32] K. Kaibuchi,et al. RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. , 2004, Hypertension research : official journal of the Japanese Society of Hypertension.
[33] H. Shimokawa. Rho-kinase as a Novel Therapeutic Target in Treatment of Cardiovascular Diseases , 2002, Journal of cardiovascular pharmacology.
[34] David G. Behm,et al. Pharmacological characterization of SB‐710411 (Cpa‐c[D‐Cys‐Pal‐D‐Trp‐Lys‐Val‐Cys]‐Cpa‐amide), a novel peptidic urotensin‐II receptor antagonist , 2002, British journal of pharmacology.
[35] Hiroko Oshima,et al. ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles , 2005, The Journal of cell biology.
[36] Anne J. Ridley,et al. ROCKs: multifunctional kinases in cell behaviour , 2003, Nature Reviews Molecular Cell Biology.
[37] 伊藤 浩司. Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system : Possible involvement in neural mechanisms of hypertension , 2003 .
[38] J. Galmiche,et al. Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. , 2003, Gastroenterology.
[39] J. Liao,et al. ROCKs as therapeutic targets in cardiovascular diseases , 2005, Expert review of cardiovascular therapy.
[40] K. Kaibuchi,et al. Regulation and functions of Rho-associated kinase. , 2000, Experimental cell research.
[41] W. Bao,et al. Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury. , 2004, Cardiovascular research.