Unexpected partial H1-receptor agonism of imidazole-type histamine H3-receptor antagonists lacking a basic side chain

[1]  H. Pertz,et al.  Structure-activity relationships of histamine H1-receptor agonists. , 2004, Mini reviews in medicinal chemistry.

[2]  R. Seifert,et al.  Structure-activity relationships of histamine H2 receptor ligands. , 2004, Mini reviews in medicinal chemistry.

[3]  H. Stark,et al.  Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum: evidence for H3 receptor heterogeneity? , 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

[4]  R. Seifert,et al.  Structure-Activity Relationships of Histamine H_2 Receptor Ligands, , 2004 .

[5]  Rob Leurs,et al.  A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine. , 2003, Journal of medicinal chemistry.

[6]  R. Seifert,et al.  N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists. , 2003, Journal of medicinal chemistry.

[7]  J. Schwartz,et al.  Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. , 2002, Journal of medicinal chemistry.

[8]  J. Schwartz,et al.  The histamine H3 receptor and its ligands. , 2001, Progress in medicinal chemistry.

[9]  K. Tanaka,et al.  Molecular cloning and characterization of a new human histamine receptor, HH4R. , 2000, Biochemical and biophysical research communications.

[10]  Y. Masuho,et al.  Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes* , 2000, The Journal of Biological Chemistry.

[11]  J. Schwartz,et al.  Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. , 2000, Journal of medicinal chemistry.

[12]  J. Schwartz,et al.  New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. , 2000, Journal of medicinal chemistry.

[13]  H. Timmerman,et al.  Selective ligands as tools to study histamine receptors. , 2000, European journal of medicinal chemistry.

[14]  J. Schwartz,et al.  Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity. , 1999, Journal of medicinal chemistry.

[15]  H. Stark,et al.  Ciproxifan and chemically related compounds are highly potent and selective histamine H3-receptor antagonists , 1998, Naunyn-Schmiedeberg's Archives of Pharmacology.

[16]  J. Schwartz,et al.  Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. , 1998, The Journal of pharmacology and experimental therapeutics.

[17]  H. Haas,et al.  International Union of Pharmacology. XIII. Classification of histamine receptors. , 1997, Pharmacological reviews.

[18]  M. Garbarg,et al.  Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues. , 1995, Journal of medicinal chemistry.

[19]  W. Schunack,et al.  Developments in histamine H1-receptor agonists. , 1995, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[20]  A. Kaumann,et al.  On the statistics of drug-receptor constants for partial agonists. , 1976, The Journal of pharmacology and experimental therapeutics.

[21]  R. Furchgott.  The Classification of Adrenoceptors (Adrenergic Receptors). An Evaluation from the Standpoint of Receptor Theory , 1972 .

[22]  Van Rossum Jm.  Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. , 1963 .

[23]  H. Schild,et al.  SOME QUANTITATIVE USES OF DRUG ANTAGONISTS , 1997, British journal of pharmacology and chemotherapy.