Short review of the biomedical properties and application of magnesium alloys for bone tissue bioengineering

Aim: to review current scientific literature concerning the main advances and problems of magnesium (Mg) alloys for traumatology and orthopedics. Methodology of the study. Analytical review based the comprehensive investigation of public scientific and technological sources. Results of the study. Modern knowledge about classification, in vitro and in vivo biodegradation, biomechanics, local and general biocompatibilities, clinical efficacy, and hazards of infectious complications in conditions of osteosynthesis with implants made of Mg alloys with or without protective (anticorrosion and antimicrobial) coatings is presented. Conclusion. Fast degradation and a risk of periprosthetic infection strongly limit clinical application of implants made of Mg and its alloys. Development of novel Mg alloys and their modification by incorporating antimicrobial elements into their body or protective coating is a promising direction to control biomedical characteristics of Mg alloys.

[1]  F. Witte,et al.  Biodegradable Metals , 2018, Biomaterials Science.

[2]  M. Dinescu,et al.  Hydroxyapatite coatings on Mg-Ca alloy prepared by Pulsed Laser Deposition: Properties and corrosion resistance in Simulated Body Fluid , 2018, Ceramics International.

[3]  S. Ullah,et al.  Advances and Challenges of Biodegradable Implant Materials with a Focus on Magnesium-Alloys and Bacterial Infections , 2018, Metals.

[4]  H. Hermawan.  Updates on the research and development of absorbable metals for biomedical applications , 2018, Progress in Biomaterials.

[5]  Xinbing Zhao,et al.  Biodegradable Magnesium Alloys Developed as Bone Repair Materials: A Review , 2018, Scanning.

[6]  K. Daniilidis,et al.  Bioabsorbable magnesium versus standard titanium compression screws for fixation of distal metatarsal osteotomies - 3 year results of a randomized clinical trial. , 2017, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[7]  Frank Witte,et al.  Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective. , 2017, Biomaterials.

[8]  H. Bail,et al.  Bioabsorbable metal screws in traumatology: A promising innovation , 2017, Trauma case reports.

[9]  M. Basista,et al.  Recent advances in research on magnesium alloys and magnesium–calcium phosphate composites as biodegradable implant materials , 2017, Journal of biomaterials applications.

[10]  James F Curtin,et al.  Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications. , 2016, Materials science & engineering. C, Materials for biological applications.

[11]  A. Cricenti,et al.  Glass-ceramic coated Mg-Ca alloys for biomedical implant applications. , 2016, Materials science & engineering. C, Materials for biological applications.

[12]  M. Rohde,et al.  Susceptibility of metallic magnesium implants to bacterial biofilm infections. , 2016, Journal of biomedical materials research. Part A.

[13]  S. Gnedenkov,et al.  Corrosion-resistant composite coatings on biodegradable magnesium alloys: In vitro studies , 2016, Russian Journal of Inorganic Chemistry.

[14]  Yangde Li,et al.  Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head. , 2016, Biomaterials.

[15]  Akiko Yamamoto,et al.  Biocompatibility and in Vitro Degradation Behavior of Magnesium-Calcium Alloy Coated with Calcium Phosphate Using an Unconventional Electrolyte. , 2016, ACS biomaterials science & engineering.

[16]  Diego Mantovani,et al.  Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy , 2016, Proceedings of the National Academy of Sciences.

[17]  Frank Feyerabend,et al.  Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates? A review. , 2015, Acta biomaterialia.

[18]  Frank Feyerabend,et al.  Magnesium-based implants: a mini-review. , 2014, Magnesium research.

[19]  S. Dorozhkin.  Calcium orthophosphate coatings on magnesium and its biodegradable alloys. , 2014, Acta biomaterialia.

[20]  Andrea Meyer-Lindenberg,et al.  Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant. , 2013, Acta biomaterialia.

[21]  P. Kumta,et al.  In vitro degradation and cytotoxicity response of Mg-4% Zn-0.5% Zr (ZK40) alloy as a potential biodegradable material. , 2013, Acta biomaterialia.

[22]  W. Heineman,et al.  Fast escape of hydrogen from gas cavities around corroding magnesium implants. , 2013, Acta biomaterialia.

[23]  Daokui Xu,et al.  Relationship between fatigue crack initiation and activated {101¯2} twins in as-extruded pure magnesium , 2013 .

[24]  C. Stukenborg-Colsman,et al.  Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: short term results of the first prospective, randomized, controlled clinical pilot study , 2013, Biomedical engineering online.

[25]  Ke Yang,et al.  Biodegradable Materials for Bone Repairs: A Review , 2013 .

[26]  T. Lei,et al.  Effects of Zn on microstructure, mechanical properties and corrosion behavior of Mg-Zn alloys , 2012 .

[27]  J. Parvizi,et al.  Periprosthetic Joint Infection: What is on the Horizon? , 2012, The International journal of artificial organs.

[28]  Ling Qin,et al.  Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[29]  N. Kirkland,et al.  Magnesium biomaterials: Past, present and future , 2012 .

[30]  P. Uggowitzer,et al.  Magnesium alloys for temporary implants in osteosynthesis: in vivo studies of their degradation and interaction with bone. , 2012, Acta biomaterialia.

[31]  Lei Guo,et al.  In vitro and in vivo evaluations on osteogenesis and biodegradability of a β-tricalcium phosphate coated magnesium alloy. , 2012, Journal of biomedical materials research. Part A.

[32]  Yuebin B. Guo,et al.  Biodegradable Orthopedic Magnesium-Calcium (MgCa) Alloys, Processing, and Corrosion Performance , 2012, Materials.

[33]  Baoping Zhang,et al.  Mechanical properties, degradation performance and cytotoxicity of Mg–Zn–Ca biomedical alloys with different compositions , 2011 .

[34]  Yufeng Zheng,et al.  Research activities of biomedical magnesium alloys in China , 2011 .

[35]  M. Kietzmann,et al.  Effects of Degradable Mg-Ca Alloys on Dendritic Cell Function , 2011, Journal of biomaterials applications.

[36]  Fritz Thorey,et al.  Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: a comparative in vivo study in rabbits. , 2011, Acta biomaterialia.

[37]  R. Walter,et al.  In-vitro degradation behaviour of WE54 magnesium alloy in simulated body fluid , 2011 .

[38]  R. Buchheit,et al.  Electrochemical Properties of Intermetallic Phases and Common Impurity Elements in Magnesium Alloys , 2011 .

[39]  A. Fekry,et al.  Electrochemical behavior of magnesium alloys as biodegradable materials in Hank's solution , 2010 .

[40]  Frank Witte,et al.  The history of biodegradable magnesium implants: a review. , 2010, Acta biomaterialia.

[41]  Duane A Robinson,et al.  In vitro antibacterial properties of magnesium metal against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. , 2010, Acta biomaterialia.

[42]  J. Gray-Munro,et al.  Influence of surface modification on the in vitro corrosion rate of magnesium alloy AZ31. , 2009, Journal of biomedical materials research. Part A.

[43]  Ke Yang,et al.  In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation. , 2009, Journal of biomedical materials research. Part A.

[44]  C. Xie,et al.  In vitro degradation, hemolysis and MC3T3-E1 cell adhesion of biodegradable Mg–Zn alloy , 2009 .

[45]  Yufeng Zheng,et al.  In vitro corrosion and biocompatibility of binary magnesium alloys. , 2009, Biomaterials.

[46]  Yufeng Zheng,et al.  The development of binary Mg-Ca alloys for use as biodegradable materials within bone. , 2008, Biomaterials.

[47]  Ke Yang,et al.  In vitro corrosion behaviour of Mg alloys in a phosphate buffered solution for bone implant application , 2008, Journal of materials science. Materials in medicine.

[48]  Frank Witte,et al.  In vitro and in vivo corrosion measurements of magnesium alloys. , 2006, Biomaterials.

[49]  Alexis M Pietak,et al.  Magnesium and its alloys as orthopedic biomaterials: a review. , 2006, Biomaterials.

[50]  G. Song.  Recent Progress in Corrosion and Protection of Magnesium Alloys , 2005 .

[51]  H. Haferkamp,et al.  In vivo corrosion of four magnesium alloys and the associated bone response. , 2005, Biomaterials.

[52]  A. Yamamoto,et al.  Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells. , 1998, Journal of biomedical materials research.

[53]  M. Mourot,et al.  Study of the corrosionin vitro andin vivo of magnesium anodes involved in an implantable bioelectric battery , 1975, Medical and biological engineering.

[54]  Motoki Inoue,et al.  In vitro and in vivo biocompatibility and corrosion behaviour of a bioabsorbable magnesium alloy coated with octacalcium phosphate and hydroxyapatite. , 2015, Acta biomaterialia.

[55]  S. Stanzl-Tschegg,et al.  Bone-implant interface strength and osseointegration: Biodegradable magnesium alloy versus standard titanium control. , 2011, Acta biomaterialia.