Hemispheric asymmetry in depression and mania. A longitudinal QEEG study in bipolar disorder.

BACKGROUND previous research has been inconclusive about the nature of hemispheric asymmetry in emotional processing. METHOD 13 patients with DSM-IV bipolar disorder received repeated QEEGs over 2 years in different mood states. Z-score measures of asymmetry were assessed. RESULTS asymmetry in frontotemporal slow-wave activity appeared to be in opposite directions in depression compared to mania/hypomania. CONCLUSIONS mood change in bipolar disorder is associated with change in QEEG asymmetry. LIMITATIONS study of larger numbers of more homogenous patients under similar conditions is needed. CLINICAL RELEVANCE study of mood state-dependent asymmetry changes in bipolar disorder may lead to better understanding of hemispheric processing of emotion.

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