Intravitreal Sirolimus for the Treatment of Noninfectious Uveitis: Evolution through Preclinical and Clinical Studies.
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Q. Nguyen | D. Do | P. Merrill | M. Ibrahim | Y. Sepah | A. Banker | A. Leonardi | M. Chernock | Sri Mudumba | Q. Nguyen
[1] A. Dick,et al. Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III. , 2018, Ophthalmology.
[2] A. Denniston,et al. Uveitis: a sight-threatening disease which can impact all systems , 2017, Postgraduate Medical Journal.
[3] M. Galeazzi,et al. Impact of Uveitis on Quality of Life: A Prospective Study from a Tertiary Referral Rheumatology-Ophthalmology Collaborative Uveitis Center in Italy. , 2017, The Israel Medical Association journal : IMAJ.
[4] Matthieu Defrance,et al. MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis , 2017, Journal of Neuroinflammation.
[5] S. Srivastava,et al. Association Between Visual Function Response and Reduction of Inflammation in Noninfectious Uveitis of the Posterior Segment. , 2017, Investigative ophthalmology & visual science.
[6] Jia Liu,et al. Intravitreal infusion: A novel approach for intraocular drug delivery , 2016, Scientific Reports.
[7] Q. Nguyen,et al. Intravitreal Sirolimus for Noninfectious Uveitis: A Phase III Sirolimus Study Assessing Double-masKed Uveitis TReAtment (SAKURA). , 2016, Ophthalmology.
[8] Cecilia S Lee,et al. Management of noninfectious posterior uveitis with intravitreal drug therapy , 2016, Clinical ophthalmology.
[9] A. Dick,et al. Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial , 2016, The Lancet.
[10] A. Heiligenhaus,et al. Adalimumab in Patients with Active Noninfectious Uveitis. , 2016, The New England journal of medicine.
[11] Q. Nguyen,et al. The Effect of Different Dosing Schedules of Intravitreal Sirolimus, a Mammalian Target of Rapamycin (mTOR) Inhibitor, in the Treatment of Non-Infectious Uveitis (An American Ophthalmological Society Thesis). , 2016, Transactions of the American Ophthalmological Society.
[12] A. Dick,et al. Direct and indirect resource use, healthcare costs and work force absence in patients with non‐infectious intermediate, posterior or panuveitis , 2016, Acta ophthalmologica.
[13] Michael N. Hall,et al. Architecture of human mTOR complex 1 , 2016, Science.
[14] E. Cunningham,et al. Sustained-release Corticosteroids for Uveitis , 2015, Ocular immunology and inflammation.
[15] A. Urtti,et al. Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data. , 2015, Experimental eye research.
[16] J. Kempen,et al. Prevalence and Risk Factors of Epiretinal membrane in the Multicenter Uveitis Steroid Treatment (MUST) Trial , 2015 .
[17] N. Jones. The Manchester Uveitis Clinic: The First 3000 Patients—Epidemiology and Casemix , 2015, Ocular immunology and inflammation.
[18] N. Jones. The Manchester Uveitis Clinic: The first 3000 patients, 2: Uveitis Manifestations, Complications, Medical and Surgical Management , 2015, Ocular immunology and inflammation.
[19] Q. Nguyen,et al. One-Year Outcomes of the SAVE Study: Sirolimus as a Therapeutic Approach for UVEitis. , 2015, Translational vision science & technology.
[20] A. Dick,et al. Multicenter study of intravitreal dexamethasone implant in noninfectious uveitis: indications, outcomes, and reinjection frequency. , 2014, American journal of ophthalmology.
[21] A. Bar,et al. Long-term clinical outcome and causes of vision loss in patients with uveitis. , 2014, Ophthalmology.
[22] George A. Williams,et al. INTRAVITREAL INJECTION TECHNIQUE AND MONITORING: Updated Guidelines of an Expert Panel , 2014, Retina.
[23] A. Dick,et al. Autoimmune and autoinflammatory mechanisms in uveitis , 2014, Seminars in Immunopathology.
[24] J. Rosenbaum,et al. Update on the use of systemic biologic agents in the treatment of noninfectious uveitis , 2014, Biologics : targets & therapy.
[25] D. Chu,et al. Healthcare costs and utilization for privately insured patients treated for non-infectious uveitis in the USA , 2013, Journal of Ophthalmic Inflammation and Infection.
[26] Jacques P. Brown,et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy , 2013, Allergy, Asthma & Clinical Immunology.
[27] F. Bandello,et al. Review on the Worldwide Epidemiology of Uveitis , 2013, European journal of ophthalmology.
[28] J. Naor,et al. Ocular tolerability and efficacy of intravitreal and subconjunctival injections of sirolimus in patients with non-infectious uveitis: primary 6-month results of the SAVE Study , 2013, Journal of Ophthalmic Inflammation and Infection.
[29] J. Naor,et al. Tolerability and pharmacokinetics of intravitreal sirolimus. , 2012, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
[30] Hongbo Chi,et al. Regulation and function of mTOR signalling in T cell fate decisions , 2012, Nature Reviews Immunology.
[31] M. Horton,et al. Regulation of immune responses by mTOR. , 2012, Annual review of immunology.
[32] A. Dick,et al. Interplay between innate and adaptive immunity in the development of non-infectious uveitis , 2012, Progress in Retinal and Eye Research.
[33] J. Vander. Randomized Comparison of Systemic Anti-inflammatory Therapy Versus Fluocinolone Acetonide Implant for Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment Trial , 2012 .
[34] George A. Williams,et al. A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema. , 2012, Ophthalmology.
[35] P. Murray,et al. Understanding uveitis: The impact of research on visual outcomes , 2011, Progress in Retinal and Eye Research.
[36] T. Louis,et al. Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. , 2011, Ophthalmology.
[37] C. Lowder,et al. Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis. , 2011, Archives of ophthalmology.
[38] P. Worley,et al. The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling , 2011, Nature Immunology.
[39] W. Feuer,et al. Scale for photographic grading of vitreous haze in uveitis. , 2010, American journal of ophthalmology.
[40] R. Caspi. A look at autoimmunity and inflammation in the eye. , 2010, The Journal of clinical investigation.
[41] P. Chévez-Barrios,et al. Testing intravitreal toxicity of rapamycin in rabbit eyes. , 2009, Arquivos brasileiros de oftalmologia.
[42] B. Gilger,et al. Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses. , 2008, Journal of veterinary pharmacology and therapeutics.
[43] Q. Nguyen,et al. Treating Chronic Noninfectious Posterior Segment Uveitis: The Impact of Cumulative Damage Proceedings of an Expert Panel Roundtable Discussion , 2006, Retina.
[44] Douglas A Jabs,et al. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. , 2005, American journal of ophthalmology.
[45] H. Dua,et al. The efficacy of sirolimus in the treatment of patients with refractory uveitis , 2005, British Journal of Ophthalmology.
[46] Andrew D. Dick,et al. The standardization of uveitis nomenclature (SUN) working group; standardization of uveitis nomenclature for reporting clinical data: Results of the first international workshop , 2005 .
[47] S. Sehgal. Sirolimus: its discovery, biological properties, and mechanism of action. , 2003, Transplantation proceedings.
[48] P. Taylor,et al. From Beach to Bedside: History of the Development of Sirolimus , 2001, Therapeutic drug monitoring.
[49] S. Yalkowsky,et al. Solubilization of rapamycin. , 2001, International journal of pharmaceutics.
[50] M. Metcalfe,et al. Rapamycin in transplantation: a review of the evidence. , 2001, Kidney international.
[51] R. V. Van Gelder,et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. , 2000, American journal of ophthalmology.
[52] V. Berlin,et al. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[53] C. Chan,et al. Treatment of autoimmune uveoretinitis in the rat with rapamycin, an inhibitor of lymphocyte growth factor signal transduction. , 1993, Current eye research.
[54] Stuart L. Schreiber,et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes , 1991, Cell.
[55] R. Nussenblatt,et al. Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. , 1985, Ophthalmology.