AFLATOXIN PROBLEM IN CORN AND POSSIBLE SOLUTIONS

E. B. LILLEHOJ I Northern Regional Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Peoria, Ill. 61604. 2 Agricultural Research Service, U.S. Department of Agriculture, University of Missouri, Columbia, Mo. 65201. Of the wide array of identified, toxic, fungal metabolites or mycotoxins, the aflatoxins have been studied the most intensively. Expanding research effort developed especially after aflatoxins were recognized as substances that occur naturally in some commodities traditionally used for human food and animal feed. These toxins are highly carcinogenic in various animal species and at sublethal levels can dramatically reduce feed efficiency and the general health of domestic animals. Historically, .aflatoxins were discovered in the early 1960's after an outbreak of a disease in turkeys was attributed to a fungal-contaminated peanut meal (14). The predominant fungus in the meal was Aspergillus flavus Link ex Fr. This organism is widely distributed in nature, occurring in soil and various plant residues. The genus Aspergillus is divided into a number of sections of closely related species; A. flavus is taxonomically associated with the larger Aspergillus flavus-oryzae group (43). Members of this group are broadly characterized by production of greenishyellow spores and by the absence of ascospores.

[1]  C. Christensen Deterioration of stored grains by fungi , 1957, The Botanical Review.

[2]  C. W. Hesseltine,et al.  Aspergillus flavus infection and aflatoxin production in mixtures of high-moisture and dry maize☆ , 1976 .

[3]  W. Kwolek,et al.  Aflatoxin production and Lepidopteran insect injury on corn in Georgia , 1975 .

[4]  Shotwell Ol,et al.  A quantitative method for determination of aflatoxin B in roasted corn. , 1975 .

[5]  H. W. Anderson,et al.  Aflatoxin contamination of corn in the field. , 1975, Journal of agricultural and food chemistry.

[6]  M. S. Zuber,et al.  Aflatoxin Production in Aspergillus flavus Inoculated Ears of Corn Grown at Diverse Locations , 1975 .

[7]  O. Brekke,et al.  Cleaning trials for corn containing aflatoxin , 1975 .

[8]  M. M. Kulik,et al.  Susceptibility of freshly picked ear corn to invasion by fungi. , 1975, Applied microbiology.

[9]  B. Mackey,et al.  Incidence of aflatoxin in California almonds. , 1975, Applied microbiology.

[10]  T. Campbell,et al.  Implication of mycotoxins for human health. , 1974, Journal of agricultural and food chemistry.

[11]  H. G. Wiseman,et al.  The transmission of aflatoxin B1 into eggs. , 1974, Poultry science.

[12]  G. W. Rambo,et al.  Preharvest Inoculation and Infection of Dent Corn Ears with Aspergillus flavus and A. parasiticus , 1974 .

[13]  J. T. Bell,et al.  Effects of ammoniation on aflatoxins in rations fed lactating cows , 1973, Journal of the American Oil Chemists' Society.

[14]  R. Adamson,et al.  Occurrence of a primary liver carcinoma in a Rhesus monkey fed aflatoxin B 1 . , 1973, Journal of the National Cancer Institute.

[15]  L. A. Goldblatt Learning to live with mycotoxins: aflatoxin - a case history , 1973 .

[16]  A. D. Campbell,et al.  Aflatoxin residues in bacon pigs , 1973 .

[17]  E. Lillehoj Feed sources and conditions conducive to production of aflatoxin, ochratoxin, Fusarium toxins, and zearalenone. , 1973, Journal of the American Veterinary Medical Association.

[18]  R. V. Bhat,et al.  Factor responsible for varietal differences in aflatoxin production in maize. , 1972, Journal of agricultural and food chemistry.

[19]  R. C. Shank,et al.  Dietary aflatoxins and human liver cancer. III. Field survey of rural Thai families for ingested aflatoxins , 1972 .

[20]  R. C. Shank,et al.  Dietary aflatoxins and human liver cancer. II. Aflatoxins in market foods and foodstuffs of Thailand and Hong Kong , 1972 .

[21]  A. Keyl,et al.  Aflatoxin effects in livestock , 1971, Journal of the American Oil Chemists' Society.

[22]  C S Davidson,et al.  Association between aflatoxin content of food and hepatoma frequency in Uganda , 1971, Cancer.

[23]  R. Smith,et al.  Laboratory wet-milling of corn containing high levels of aflatoxin and a survey of commercial wet-milling products. , 1971 .

[24]  E. Martínez Differences Among Lines and Varieties of Maize in Susceptibility to Damage by Storage Fungi , 1971 .

[25]  C. W. Hesseltine,et al.  Survey of Corn from Different Regions for Aflatoxin, Ochratoxin, and Zearalenone , 1971 .

[26]  I. Purchase,et al.  Preliminary results from food analyses in the Inhambane area. , 1971 .

[27]  L. Salamat,et al.  Aflatoxin Ingestion and Excretion by Humans , 1971 .

[28]  C. W. Hesseltine,et al.  Survey of corn for aflatoxin, zearalenone, and ochratoxin. , 1970 .

[29]  Clyde M. Christensen,et al.  Grain Storage: The Role of Fungi in Quality Loss , 1969 .

[30]  P. B. Marsh,et al.  Relation of aflatoxins in cotton seeds at harvest to fluorescence in the fiber , 1969 .

[31]  P. B. Marsh,et al.  Mechanism of formation of a fluorescence in cotton fiber associated with aflatoxins in the seeds at harvest , 1969 .

[32]  C. W. Hesseltine,et al.  Survey of cereal grains and soybeans for the presence of aflatoxin. 1. Wheat, grain sorghum, and oats. , 1969 .

[33]  C. J. Kensler,et al.  CHAPTER XII – PROCESSING TO ENSURE WHOLESOME PRODUCTS , 1969 .

[34]  B. Oser REGULATORY ASPECTS OF CONTROL OF MYCOTOXINS IN FOODS AND FEEDS , 1969 .

[35]  J. Halver Aflatoxicosis and trout hepatoma. , 1968, Bulletin - Office international des epizooties.

[36]  H. Heitman,et al.  Aflatoxin Toxicity in Beef Cattle , 1968, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[37]  R. Carnaghan Hepatic tumours and other chronic liver changes in rats following a single oral administration of aflatoxin. , 1967, British Journal of Cancer.

[38]  H. Heitman,et al.  Aflatoxin Toxicity in Swine , 1967, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[39]  G. Wogan,et al.  Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat. , 1967, Cancer research.

[40]  G. Wogan Chemical nature and biological effects of the aflatoxins. , 1966, Bacteriological reviews.

[41]  L. Ashworth,et al.  Association of Aspergillus flavus and aflatoxins with a greenish yellow fluorescence of cotton seed. , 1966 .

[42]  W. Sippel,et al.  A disease of swine and cattle caused by eating moldy corn. II. Experimental production with pure cultures of molds. , 1957, American journal of veterinary research.