Mild cognitive impairment

[1]  P. Pinel A treatise on insanity. , 1806 .

[2]  H. Merritt,et al.  The cerebrospinal fluid , 1938 .

[3]  D. Wechsler The measurement and appraisal of adult intelligence, 4th ed. , 1958 .

[4]  V. A. Kral,et al.  Senescent forgetfulness: benign and malignant. , 1962, Canadian Medical Association journal.

[5]  G. Glaser,et al.  Familial Alzheimer's disease , 1963, Neurology.

[6]  J. G. Gilbert,et al.  A Preliminary Report on a New Memory Scale , 1968, Perceptual and motor skills.

[7]  P. Daniel,et al.  Creutzfeldt-Jakob disease. The neuropathology of a transmission experiment. , 1969, Brain : a journal of neurology.

[8]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[9]  Paul A. Bottomley,et al.  19F magnetic resonance imaging , 1977 .

[10]  J. Ware,et al.  Random-effects models for longitudinal data. , 1982, Biometrics.

[11]  B. Reisberg,et al.  The Global Deterioration Scale for assessment of primary degenerative dementia. , 1982, The American journal of psychiatry.

[12]  C. P. Hughes,et al.  A New Clinical Scale for the Staging of Dementia , 1982, British Journal of Psychiatry.

[13]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[14]  G. V. Van Hoesen,et al.  Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. , 1984, Science.

[15]  J. Ulrich,et al.  Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type , 1985, Annals of neurology.

[16]  F. Huppert,et al.  CAMDEX: A Standardised Instrument for the Diagnosis of Mental Disorder in the Elderly with Special Reference to the Early Detection of Dementia , 1986, British Journal of Psychiatry.

[17]  S. Ferris,et al.  Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group , 1986 .

[18]  Douglas L. Rosene,et al.  The Hippocampal Formation of the Primate Brain , 1987 .

[19]  P. S. St George-Hyslop,et al.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.

[20]  D. Pollen,et al.  The genetic defect causing familial Alzheimer's disease maps on chromosome 21. , 1987, Science.

[21]  W. Jagust,et al.  Longitudinal studies of regional cerebral metabolism in Alzheimer's disease , 1988, Neurology.

[22]  R. Mohs,et al.  Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. , 2002, Psychopharmacology bulletin.

[23]  T. Crook,et al.  Interrelationships among everyday memory tests: Stability of factor structure with age. , 1988 .

[24]  H. Duvernoy The Human Hippocampus: An Atlas of Applied Anatomy , 1988 .

[25]  W. Jagust,et al.  Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease , 1988, Magnetic resonance in medicine.

[26]  Antonio F. Govoni,et al.  Quantitative nmr measurements of hippocampal atrophy in Alzheimer's disease :Seab JP, Jagust WJ, Wong STS, Roos MS, Reed BR, Budinger TF (Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720, USA). Magn Reson Med 1988;8:200–208 , 1989 .

[27]  J. Morris,et al.  Very mild senile dementia of the Alzheimer type. I. Clinical assessment. , 1989, Archives of neurology.

[28]  Gwenn S. Smith,et al.  EARLY MARKER FOR ALZHEIMER'S DISEASE: THE ATROPHIC HIPPOCAMPUS , 1989, The Lancet.

[29]  J. Tsuruda,et al.  Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. , 1990, Radiology.

[30]  S. Mirra,et al.  Consortium to Establish a Registry for Alzheimer’s Disease (CERAD): Clinical, neuropsychological, and neuropathological components , 1990, Aging.

[31]  M J de Leon,et al.  CT diagnostic features of Alzheimer disease: importance of the choroidal/hippocampal fissure complex. , 1990, AJNR. American journal of neuroradiology.

[32]  A. R. Damasio,et al.  Memory‐related neural systems in Alzheimer's disease , 1990, Neurology.

[33]  C. Jack,et al.  MR imaging-based volume measurements of the hippocampal formation and anterior temporal lobe: validation studies. , 1990, Radiology.

[34]  J. M. Anderson,et al.  A quantitative histological study of early clinical and preclinical Alzheimer's disease , 1990, Neuropathology and applied neurobiology.

[35]  C. Jonker,et al.  The Amstel project: design and first findings. The course of mild cognitive impairment of the aged; a longitudinal 4-year study. , 1990, Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa.

[36]  J. Price,et al.  Very mild Alzheimer's disease , 1991, Neurology.

[37]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[38]  G. V. Van Hoesen,et al.  The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. , 1991, Cerebral cortex.

[39]  J. Price,et al.  The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease , 1991, Neurobiology of Aging.

[40]  J. Hoskinson,et al.  AETIOLOGY AND TREATMENT , 1991 .

[41]  Terry L. Jernigan,et al.  Cerebral structure on MRI, part II: Specific changes in Alzheimer's and Huntington's diseases , 1991, Biological Psychiatry.

[42]  M. Pericak-Vance,et al.  Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. , 1991, American journal of human genetics.

[43]  B. Reisberg,et al.  Mild cognitive impairment in the elderly , 1991, Neurology.

[44]  G. Ratcliff,et al.  Effects of age, gender, and education on cognitive tests in a rural elderly community sample: norms from the Monongahela Valley Independent Elders Survey. , 1991, Neuroepidemiology.

[45]  P. Scheltens,et al.  Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[46]  J. Pettegrew,et al.  N‐acetyl‐L‐aspartate and other amino acid metabolites in Alzheimer's disease brain , 1992, Neurology.

[47]  A. Delacourte,et al.  Presence of abnormally phosphorylated Tau proteins in the entorhinal cortex of aged non-demented subjects , 1992, Neuroscience Letters.

[48]  J. Weber,et al.  Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. , 1992, Science.

[49]  J. Hardy,et al.  A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene , 1992, Nature Genetics.

[50]  Bradley T. Hyman,et al.  Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease , 1992, Neurology.

[51]  D. Pollen,et al.  Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 , 1992, Nature Genetics.

[52]  C. Broeckhoven,et al.  Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3 , 1992, Nature Genetics.

[53]  J. Morris The Clinical Dementia Rating (CDR) , 1993, Neurology.

[54]  M. Leon,et al.  Hippocampal atrophy in normal aging. An association with recent memory impairment. , 1993, Archives of neurology.

[55]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[56]  B. Reisberg,et al.  A Two-Year Longitudinal Study of Cognitive Function in Normal Aging and Alzheimer's Disease , 1993, Journal of geriatric psychiatry and neurology.

[57]  Gwenn S. Smith,et al.  The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. , 1993, AJNR. American journal of neuroradiology.

[58]  J. Wegiel,et al.  COMPUTER-ASSISTED 3D-RECONSTRUCTION OF THE HIPPOCAMPAL FORMATION IN AD , 1993 .

[59]  M. Folstein,et al.  Population-based norms for the Mini-Mental State Examination by age and educational level. , 1993, JAMA.

[60]  M. Bobinski,et al.  Dilatation of the lateral part of the transverse fissure of the brain in Alzheimer's disease. , 1993, Acta neurobiologiae experimentalis.

[61]  E. R. John,et al.  Quantitative EEG correlates of cognitive deterioration in the elderly , 1994, Neurobiology of Aging.

[62]  Fergus I. M. Craik,et al.  Memory Changes in Normal Aging , 1994 .

[63]  N. Butters,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery , 1994, Neurology.

[64]  M. Sliwinski,et al.  Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons , 1994, Neurology.

[65]  M. Mega,et al.  The Neuropsychiatric Inventory , 1994, Neurology.

[66]  Michael W. Vannier,et al.  Hippocampal MR volumetry , 1994, Other Conferences.

[67]  R. Lévy,et al.  Aging-Associated Cognitive Decline , 1994, International Psychogeriatrics.

[68]  D. Schaid,et al.  Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. , 1995, JAMA.

[69]  G. Livingston,et al.  The Gospel Oak Study stage IV: the clinical relevance of subjective memory impairment in older people , 1995, Psychological Medicine.

[70]  K. Marder,et al.  Neuropsychological detection and characterization of preclinical Alzheimer's disease , 1995, Neurology.

[71]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[72]  M. Laakso,et al.  A Follow‐Up Study of Age‐Associated Memory Impairment: Neuropsychological Predictors of Dementia , 1995, Journal of the American Geriatrics Society.

[73]  G. Schellenberg,et al.  Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.

[74]  D. Hogan,et al.  Cognitive impairment in the nondemented elderly. Results from the Canadian Study of Health and Aging. , 1995, Archives of neurology.

[75]  J. Rommens,et al.  Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.

[76]  L. Wahlund,et al.  Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele ϵ4 during 14 months follow-up , 1996, Neuroscience Letters.

[77]  A. Kurz,et al.  Cerebrospinal protein tau is elevated in early Alzheimer's disease , 1996, Neuroscience Letters.

[78]  J. Morris,et al.  Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease , 1996, The Journal of Neuroscience.

[79]  W. Snow,et al.  A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment , 1996, Neurology.

[80]  P. S. St George-Hyslop,et al.  Prediction of probable Alzheimer's disease in memory-impaired patients , 1996, Neurology.

[81]  Ronald C. Petersen,et al.  Definition, course, and outcome of mild cognitive impairment , 1996 .

[82]  O Almkvist,et al.  Quantitative electroencephalography power and coherence in Alzheimer's disease and mild cognitive impairment. , 1996, Dementia.

[83]  S. Thibodeau,et al.  Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. , 1996, The New England journal of medicine.

[84]  Nick C Fox,et al.  Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study. , 1996, Brain : a journal of neurology.

[85]  C. Hock,et al.  Dependence of cerebrospinal fluid Tau protein levels on apolipoprotein E4 allele frequency in patients with Alzheimer's disease , 1997, Neuroscience Letters.

[86]  J. Trojanowski,et al.  Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology. , 1997, Biochemical and biophysical research communications.

[87]  D. Galasko,et al.  Assessment of CSF levels of tau protein in mildly demented patients with Alzheimer's disease , 1997, Neurology.

[88]  Walter Kukull,et al.  Progression to dementia in patients with isolated memory loss , 1997, The Lancet.

[89]  H. Arai Elevated cerebrospinal fluid tau protein level as a predictor of dementia in memory-impaired individuals , 1997 .

[90]  J. Démonet,et al.  Age related cognitive decline: a clinical entity? A longitudinal study of cerebral blood flow and memory performance. , 1997, Journal of neurology, neurosurgery, and psychiatry.

[91]  K. Marder,et al.  Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment. , 1997, The American journal of psychiatry.

[92]  T. Hagen,et al.  Perfusion MRI in cerebral infarction , 1997, Der Radiologe.

[93]  M. Osawa,et al.  Early-stage Alzheimer's disease and multiple subcortical infarction with mild cognitive impairment: neuropsychological comparison using an easily applicable test battery. , 1997, Dementia and geriatric cognitive disorders.

[94]  P Woodbury,et al.  A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. , 1997, The New England journal of medicine.

[95]  D. Knook,et al.  Impact of mild cognitive impairment on survival in very elderly people: cohort study , 1997, BMJ.

[96]  W. Markesbery,et al.  Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. , 1997, JAMA.

[97]  Janice E Graham,et al.  Prevalence and severity of cognitive impairment with and without dementia in an elderly population , 1997, The Lancet.

[98]  J. Kaye,et al.  Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia , 1997, Neurology.

[99]  J. Trojanowski,et al.  Effect of Genetic Risk Factors and Disease Progression on the Cerebrospinal Fluid Tau Levels in Alzheimer's Disease , 1997, Journal of the American Geriatrics Society.

[100]  A. Hofman,et al.  Insulin and Cognitive Function in an Elderly Population: The Rotterdam Study , 1997, Diabetes Care.

[101]  R. Petersen,et al.  Aging, Memory, and Mild Cognitive Impairment , 1997, International Psychogeriatrics.

[102]  Yaakov Stern,et al.  Questionable Dementia: Clinical Course and Predictors of Outcome , 1997, Journal of the American Geriatrics Society.

[103]  H. Wiśniewski,et al.  Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease , 1998, Neuroscience Letters.

[104]  R Brookmeyer,et al.  Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. , 1998, American journal of public health.

[105]  J. Tuomilehto,et al.  Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial , 1998, The Lancet.

[106]  J. Kaye,et al.  High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. , 1998, Archives of neurology.

[107]  C. van Broeckhoven,et al.  Molecular genetics of Alzheimer's disease. , 1998, Annals of medicine.

[108]  A Hofman,et al.  Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. , 1998, Human molecular genetics.

[109]  P F Renshaw,et al.  Dynamic susceptibility contrast MR imaging of regional cerebral blood volume in Alzheimer disease: a promising alternative to nuclear medicine. , 1998, AJNR. American journal of neuroradiology.

[110]  S. Hirai,et al.  Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer's disease: A study in Japan , 1998 .

[111]  A. Kurz,et al.  Tau Protein in Cerebrospinal Fluid Is Significantly Increased at the Earliest Clinical Stage of Alzheimer Disease , 1998, Alzheimer disease and associated disorders.

[112]  J. Trojanowski,et al.  Increased F2‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[113]  E. Tangalos,et al.  Normative data for the Mattis Dementia Rating Scale. , 1998, Journal of clinical and experimental neuropsychology.

[114]  H. Chertkow,et al.  Prevalence of potentially reversible dementias and actual reversibility in a memory clinic cohort. , 1998, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[115]  B L Holman,et al.  Preclinical prediction of Alzheimer's disease using SPECT , 1998, Neurology.

[116]  C. Gottfries,et al.  Identification of Cognitive Impairment in the Elderly: Homocysteine Is an Early Marker , 1998, Dementia and Geriatric Cognitive Disorders.

[117]  Y. Nakamura,et al.  Basic and clinical studies on the measurement of tau protein in cerebrospinal fluid as a biological marker for Alzheimer's disease and related disorders: multicenter study in Japan. , 1998, Methods and findings in experimental and clinical pharmacology.

[118]  C. Jack,et al.  Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment , 1999, Neurology.

[119]  P. Mehta,et al.  Quantification of sub-femtomole amounts of Alzheimer amyloid β peptides , 1999 .

[120]  K. Marder,et al.  Functional significance of mild cognitive impairment in elderly patients without a dementia diagnosis. , 1999, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[121]  W. Markesbery,et al.  Oxidative Alterations in Alzheimer's Disease , 1999, Brain pathology.

[122]  Hirofumi Sakurai,et al.  Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer’s disease , 1999, Journal of the Neurological Sciences.

[123]  Hiroyuki Arai,et al.  Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease , 1999, Neuroscience Letters.

[124]  R. Motter,et al.  Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse , 1999, Nature.

[125]  S. Rapoport,et al.  Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls , 1999, Neuroscience Letters.

[126]  Cees Jonker,et al.  Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment , 1999, Journal of Neurology.

[127]  B. Winblad,et al.  Mortality in nondemented subjects with cognitive impairment: the influence of health-related factors. , 1999, American journal of epidemiology.

[128]  S H Ferris,et al.  Neuropsychological Prediction of Decline to Dementia in Nondemented Elderly , 1999, Journal of geriatric psychiatry and neurology.

[129]  C. Fabrigoule,et al.  Functional Impairment in Instrumental Activities of Daily Living: An Early Clinical Sign of Dementia? , 1999, Journal of the American Geriatrics Society.

[130]  A. Tamaoka,et al.  [Amyloid beta protein]. , 1999, Nihon rinsho. Japanese journal of clinical medicine.

[131]  B Engvall,et al.  Cerebrospinal fluid Aβ42 is increased early in sporadic Alzheimer's disease and declines with disease progression , 1999, Annals of neurology.

[132]  G. Schellenberg,et al.  Impaired olfaction as a marker for cognitive decline: Interaction with apolipoprotein E 4 status , 1999 .

[133]  F. Fazio,et al.  Impairment of Neocortical Metabolism Predicts Progression in Alzheimer’s Disease , 1999, Dementia and Geriatric Cognitive Disorders.

[134]  K. Blennow,et al.  Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample. , 1999, Neurology.

[135]  E. Matsubara,et al.  Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease , 1999, Neuroscience Letters.

[136]  M. Rossor,et al.  Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer's disease , 1999, Neuroscience Letters.

[137]  K. Blennow,et al.  Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease. , 1999, Archives of neurology.

[138]  L. Beckett,et al.  Entorhinal Cortex β-Amyloid Load in Individuals with Mild Cognitive Impairment , 1999, Experimental Neurology.

[139]  Oliver T Wolf,et al.  MRI volume of the amygdala: a reliable method allowing separation from the hippocampal formation , 1999, Psychiatry Research: Neuroimaging.

[140]  B. Winblad,et al.  Occurrence and progression of dementia in a community population aged 75 years and older: relationship of antihypertensive medication use. , 1999, Archives of neurology.

[141]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[142]  L. Bouter,et al.  Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. , 1999, The American journal of psychiatry.

[143]  J. Morris,et al.  Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease , 1999, Annals of neurology.

[144]  D E Kuhl,et al.  Neuropsychological function and cerebral glucose utilization in isolated memory impairment and Alzheimer's disease. , 1999, Journal of psychiatric research.

[145]  P. Lansbury,et al.  Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain. , 1999, Journal of medicinal chemistry.

[146]  H Bergman,et al.  Lack of Prognostic Significance of SPECT Abnormalities in Non-demented Elderly Subjects with Memory Loss , 1999, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[147]  B. Reisberg,et al.  Equilibrium and Limb Coordination in Mild Cognitive Impairment and Mild Alzheimer's Disease , 1999, Journal of the American Geriatrics Society.

[148]  G A Johnson,et al.  Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[149]  K. Blennow,et al.  Cerebrospinal fluid tau and Aβ42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment , 1999, Neuroscience Letters.

[150]  P. Visser Predictors of Alzheimer type dementia in subjects with mild cognitive impairments , 2000 .

[151]  A. Nordberg,et al.  Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer’s disease , 2000, Neurobiology of Aging.

[152]  H. Gertz,et al.  Do white matter changes contribute to the subsequent development of dementia in patients with mild cognitive impairment? A longitudinal study , 2000, International journal of geriatric psychiatry.

[153]  J. Jolles,et al.  Distinction Between Preclinical Alzheimer's Disease and Depression , 2000, Journal of the American Geriatrics Society.

[154]  K. Marder,et al.  Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. , 2000, The American journal of psychiatry.

[155]  C. Jack,et al.  Rates of hippocampal atrophy correlate with change in clinical status in aging and AD , 2000, Neurology.

[156]  J. Detre,et al.  Assessment of cerebral blood flow in Alzheimer's disease by spin‐labeled magnetic resonance imaging , 2000, Annals of neurology.

[157]  M. Neumann,et al.  Decreased CSF amyloid β42 and normal tau levels in dementia with Lewy bodies , 2000, Neurology.

[158]  P. Scheltens,et al.  Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects , 2000, Journal of Neurology.

[159]  N. Fox Increased rates of atrophy in early and preclinical AD: Studies with registration of serial MRI , 2000, Neurobiology of Aging.

[160]  L. Fratiglioni,et al.  The evolution of cognitive impairment in the non-demented elderly. Population data from the Kungsholmen project , 2000, Neurobiology of Aging.

[161]  K. Blennow,et al.  CSF levels of tau, β-amyloid1–42 and GAP-43 in frontotemporal dementia, other types of dementia and normal aging , 2000, Journal of Neural Transmission.

[162]  J. Trojanowski,et al.  Increased 8,12‐iso‐iPF2α‐VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity , 2000, Annals of neurology.

[163]  Robert J. Cotter,et al.  Elevated Aβ42 in Skeletal Muscle of Alzheimer Disease Patients Suggests Peripheral Alterations of AβPP Metabolism , 2000 .

[164]  D. Zaitchik,et al.  Predicting conversion to Alzheimer disease using standardized clinical information. , 2000, Archives of neurology.

[165]  H. Chertkow,et al.  Evaluation of heme oxygenase-1 as a systemic biological marker of sporadic AD , 2000, Neurology.

[166]  J. Jolles,et al.  Course of objective memory impairment in non‐demented subjects attending a memory clinic and predictors of outcome , 2000, International journal of geriatric psychiatry.

[167]  J. Mintzer,et al.  Anticholinergic side-effects of drugs in elderly people , 2000, Journal of the Royal Society of Medicine.

[168]  Bin Zhang,et al.  In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. , 2000 .

[169]  G. Ratcliff,et al.  Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented , 2000, Neurology.

[170]  M Takasaki,et al.  Magnetization transfer measurements of the hippocampus in patients with Alzheimer's disease, vascular dementia, and other types of dementia. , 2000, AJNR. American journal of neuroradiology.

[171]  H. Wiśniewski,et al.  Plasma and cerebrospinal fluid Levels of amyloid β proteins 1-40 and 1-42 in Alzheimer disease , 2000 .

[172]  J. Touchon,et al.  Mild cognitive impairment: conceptual basis and current nosological status , 2000, The Lancet.

[173]  E. Cochran,et al.  Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease , 2000, The Journal of comparative neurology.

[174]  E G Tangalos,et al.  Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease , 2000, Neurology.

[175]  K. Blennow,et al.  Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization , 2000, Neuroscience Letters.

[176]  Nobuyuki Okamura,et al.  CSF Phosphorylated Tau Protein and Mild Cognitive Impairment: A Prospective Study , 2000, Experimental Neurology.

[177]  Hilkka Soininen,et al.  Relationship between apoE genotype and CSF β-amyloid (1–42) and tau in patients with probable and definite Alzheimer’s disease , 2000, Neurobiology of Aging.

[178]  M. Tierney,et al.  Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment , 2000, Lipids.

[179]  R. Havlik,et al.  Midlife blood pressure and dementia: the Honolulu–Asia aging study☆ , 2000, Neurobiology of Aging.

[180]  H. Soininen,et al.  Three-year follow-up of cerebrospinal fluid tau, β-amyloid 42 and 40 concentrations in Alzheimer's disease , 2000, Neuroscience Letters.

[181]  J. Touchon,et al.  Subclinical ognitive impairment: Epidemiology and clinical characteristics , 2000 .

[182]  N. Holtzman,et al.  Will genetics revolutionize medicine? , 2000, The New England journal of medicine.

[183]  H Jick,et al.  Statins and the risk of dementia , 2000, The Lancet.

[184]  R. Mayeux,et al.  Natural history of Alzheimer’s disease , 2001, Aging.

[185]  E. Tangalos,et al.  CME Practice parameter: , 2022 .

[186]  P. Mehta,et al.  Amyloid β protein 1–40 and 1–42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease , 2001, Neuroscience Letters.

[187]  J. Touchon,et al.  Classification criteria for mild cognitive impairment , 2001, Neurology.

[188]  P. Whitehouse The end of Alzheimer disease. , 2001, Alzheimer disease and associated disorders.

[189]  H. Reiber,et al.  Dynamics of brain-derived proteins in cerebrospinal fluid. , 2001, Clinica chimica acta; international journal of clinical chemistry.

[190]  J. Price,et al.  Mild cognitive impairment represents early-stage Alzheimer disease. , 2001, Archives of neurology.

[191]  L. Parnetti,et al.  CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies , 2001, Neurological Sciences.

[192]  L. Fratiglioni,et al.  Stability of the preclinical episodic memory deficit in Alzheimer's disease. , 2001, Brain : a journal of neurology.

[193]  B. Oken Practice parameter: Management of dementia (an evidence-based review) , 2001, Neurology.

[194]  Nick C Fox,et al.  Rates of global and regional cerebral atrophy in AD and frontotemporal dementia , 2001, Neurology.

[195]  A. Convit,et al.  Hippocampal formation glucose metabolism and volume losses in MCI and AD , 2001, Neurobiology of Aging.

[196]  C. Junqué,et al.  Neuropsychological and Genetic Differences Between Age‐Associated Memory Impairment and Mild Cognitive Impairment Entities , 2001, Journal of the American Geriatrics Society.

[197]  K. Blennow,et al.  Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke , 2001, Neuroscience Letters.

[198]  K. Blennow,et al.  Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice. , 2001, Archives of neurology.

[199]  B. Reisberg,et al.  The Alzheimer's Disease Activities of Daily Living International Scale (ADL-IS) , 2001, International Psychogeriatrics.

[200]  Y. Stern,et al.  Influence of leisure activity on the incidence of Alzheimer’s Disease , 2001, Neurology.

[201]  G. Pearlson,et al.  Diffusion Tensor Imaging and Axonal Tracking in the Human Brainstem , 2001, NeuroImage.

[202]  O Almkvist,et al.  Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment , 2001, Neuroreport.

[203]  D. Bennett,et al.  Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment , 2001, Annals of neurology.

[204]  A. Drzezga,et al.  Primary Degenerative Mild Cognitive Impairment: Study Population, Clinical, Brain Imaging and Biochemical Findings , 2001, Dementia and Geriatric Cognitive Disorders.

[205]  M. Bobinski,et al.  Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-d-glucose/positron-emission tomography (FDG/PET) , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[206]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[207]  A. Korten,et al.  Memory complaints as a precursor of memory impairment in older people: a longitudinal analysis over 7–8 years , 2001, Psychological Medicine.

[208]  K. Blennow,et al.  Both total and phosphorylated tau are increased in Alzheimer's disease , 2001, Journal of neurology, neurosurgery, and psychiatry.

[209]  J. Lindsay,et al.  Physical activity and risk of cognitive impairment and dementia in elderly persons. , 2001, Archives of neurology.

[210]  J Currie,et al.  Memory decline in healthy older people , 2001, Neurology.

[211]  G. Heit,et al.  The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer’s type , 2001, Neurology.

[212]  N. Schuff,et al.  Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease , 2001, Journal of neurology, neurosurgery, and psychiatry.

[213]  M. Albert,et al.  Preclinical prediction of AD using neuropsychological tests , 2001, Journal of the International Neuropsychological Society.

[214]  Oliver T. Wolf,et al.  Volumetric analysis of the pre-frontal regions: findings in aging and schizophrenia , 2001, Psychiatry Research: Neuroimaging.

[215]  D. Bennett,et al.  MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease☆ ☆ This research was supported by grants P01 AG09466 and P30 AG10161 from the National Institute on Aging, National Institutes of Health. , 2001, Neurobiology of Aging.

[216]  Jeffrey L. Cummings,et al.  Practice parameter: Diagnosis of dementia (an evidence-based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology , 2001 .

[217]  J. Dickens,et al.  Prevalence of cognitive impairment , 2001, Neurology.

[218]  J. Morris,et al.  Evidence That Age-Associated Memory Impairment Is Not a Normal Variant of Aging , 2001, Alzheimer disease and associated disorders.

[219]  H. Arai,et al.  Cerebrospinal Fluid Amyloid β1–42 Levels in the Mild Cognitive Impairment Stage of Alzheimer's Disease , 2001, Experimental Neurology.

[220]  S. Hirai,et al.  The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently , 2001, Neurobiology of Aging.

[221]  Katharina Buerger,et al.  Large‐scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease , 2001, Annals of neurology.

[222]  J. Touchon,et al.  Disability and mild cognitive impairment: a longitudinal population‐based study , 2001, International journal of geriatric psychiatry.

[223]  Martin Orrell,et al.  Cognitive rehabilitation interventions targeting memory functioning in early-stage Alzheimer's disease and vascular dementia , 2001 .

[224]  K. Blennow,et al.  One-Carbon Metabolism and Other Biochemical Correlates of Cognitive Impairment as Visualized by Principal Component Analysis , 2001, Journal of geriatric psychiatry and neurology.

[225]  R. Floris,et al.  Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load. , 2001, AJNR. American journal of neuroradiology.

[226]  David J. Cummins,et al.  Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[227]  A. Convit,et al.  Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment , 2002, Neuroscience Letters.

[228]  Howard Chertkow,et al.  Regional magnetization transfer ratio changes in mild cognitive impairment , 2002, Magnetic resonance in medicine.

[229]  F. Boller,et al.  Apolipoprotein E ε4 allele frequency in demented and cognitively impaired patients with and without cerebrovascular disease , 2002, Journal of the Neurological Sciences.

[230]  Katharina Buerger,et al.  Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231. , 2002, Archives of neurology.

[231]  D. Bloch,et al.  Assessment of low-flow CSF drainage as a treatment for AD , 2002, Neurology.

[232]  Lars-Olof Wahlund,et al.  Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment , 2002, BMC neurology.

[233]  B. Sahakian,et al.  Is knowledge of famous people disproportionately impaired in patients with early and questionable Alzheimer's disease? , 2002, Neuropsychology.

[234]  D P Salmon,et al.  Abnormal verbal event related potentials in mild cognitive impairment and incipient Alzheimer's disease , 2002, Journal of neurology, neurosurgery, and psychiatry.

[235]  C. Lyketsos,et al.  Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. , 2002, JAMA.

[236]  C. Bottino,et al.  Volumetric MRI Measurements Can Differentiate Alzheimer's Disease, Mild Cognitive Impairment, and Normal Aging , 2002, International Psychogeriatrics.

[237]  M H Buonocore,et al.  Brain structure and cognition in a community sample of elderly Latinos , 2002, Neurology.

[238]  Brian J Bacskai,et al.  A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. , 2002, Bioorganic & medicinal chemistry letters.

[239]  P. Scheltens,et al.  Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment , 2002, Journal of neurology, neurosurgery, and psychiatry.

[240]  J. Schneider,et al.  Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease , 2002, Annals of neurology.

[241]  Masatoshi Itoh,et al.  Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease. , 2002, The American journal of psychiatry.

[242]  S. Wisniewski,et al.  Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment , 2002, Annals of neurology.

[243]  A Drzezga,et al.  Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment. , 2002, Archives of neurology.

[244]  S. Leurgans,et al.  Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease , 2002, Experimental Neurology.

[245]  I. Grundke‐Iqbal,et al.  Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. , 2002, The American journal of pathology.

[246]  H. Amièva,et al.  Incidence and outcome of mild cognitive impairment in a population-based prospective cohort , 2002, Neurology.

[247]  D. A. Bennett,et al.  Natural history of mild cognitive impairment in older persons , 2002, Neurology.

[248]  J. Trojanowski,et al.  Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. , 2002, Archives of neurology.

[249]  W. M. van der Flier,et al.  Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease , 2002, Annals of neurology.

[250]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .

[251]  George W Rebok,et al.  Effects of cognitive training interventions with older adults: a randomized controlled trial. , 2002, JAMA.

[252]  J Philip Miller,et al.  Rates of progression in mild cognitive impairment and early Alzheimer’s disease , 2002, Neurology.

[253]  Y. Stern,et al.  Functional deficits in patients with mild cognitive impairment: Prediction of AD , 2002, Neurology.

[254]  Alistair Burns,et al.  Mild cognitive impairment in older people , 2002, The Lancet.

[255]  H. Arai,et al.  CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects , 2002, Neurology.

[256]  John G. Sled,et al.  Magnetization Transfer Ratio in Mild Cognitive Impairment and Dementia of Alzheimer's Type , 2002, NeuroImage.

[257]  Tuomo Hänninen,et al.  Prevalence of mild cognitive impairment: a population‐based study in elderly subjects , 2002, Acta neurologica Scandinavica.

[258]  D. Holtzman,et al.  Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease , 2002, Journal of neurochemistry.

[259]  J. Bading,et al.  Brain Clearance of Alzheimer's Amyloid-β40 in the Squirrel Monkey: A SPECT Study in a Primate Model of Cerebral Amyloid Angiopathy , 2002, Journal of drug targeting.

[260]  J. Schneider,et al.  Individual differences in rates of change in cognitive abilities of older persons. , 2002, Psychology and aging.

[261]  Impaired financial abilities in mild cognitive impairment , 2003, Neurology.

[262]  M Orrell,et al.  Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. , 2003, The Cochrane database of systematic reviews.

[263]  B. Winblad,et al.  Pharmacoeconomics of mild cognitive impairment , 2003, Acta neurologica Scandinavica. Supplementum.

[264]  Charles DeCarli,et al.  Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment , 2003, The Lancet Neurology.

[265]  A. Barabash,et al.  Regional cerebral blood flow assessed with 99mTc-ECD SPET as a marker of progression of mild cognitive impairment to Alzheimer's disease , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[266]  Henrik Zetterberg,et al.  Cerebrospinal fluid markers for prediction of Alzheimer's disease , 2003, Neuroscience Letters.

[267]  H. Möller,et al.  Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231. , 2003, The American journal of psychiatry.

[268]  C. Broeckhoven,et al.  Evaluation of breast cancer risk assessment packages in the family history evaluation and screening programme , 2003, Journal of medical genetics.

[269]  C. Jack,et al.  Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T. , 2003, AJNR. American journal of neuroradiology.

[270]  Ronald Carl Petersen,et al.  Mild cognitive impairment : aging to Alzheimer's disease , 2003 .

[271]  D. Zaitchik,et al.  Psychiatric Symptomatology and Prodromal Alzheimer's Disease , 2003, Alzheimer disease and associated disorders.

[272]  A. Mitchell,et al.  CSF phosphorylated tau—does it constitute an accurate biological test for Alzheimer's disease? , 2003, International journal of geriatric psychiatry.

[273]  John Breitner,et al.  Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2. , 2003, Archives of neurology.

[274]  J. Trojanowski,et al.  Biological markers for therapeutic trials in Alzheimer’s disease Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer’s disease , 2003, Neurobiology of Aging.

[275]  K. Blennow,et al.  CSF markers for incipient Alzheimer's disease , 2003, The Lancet Neurology.

[276]  Kaj Blennow,et al.  Cerebrospinal fluid levels of total‐tau, phospho‐tau and Aβ42 predicts development of Alzheimer's disease in patients with mild cognitive impairment , 2003 .

[277]  Xianlin Han,et al.  Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia , 2003, Annals of neurology.

[278]  M. Mesulam,et al.  Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. , 2003, Archives of neurology.

[279]  G. Kemmler,et al.  Long-term improvements in cognitive performance through computer-assisted cognitive training: A pilot study in a residential home for older people , 2003, Aging & mental health.

[280]  M. Essig,et al.  Parahippocampal volume deficits in subjects with aging-associated cognitive decline. , 2003, The American journal of psychiatry.

[281]  K. Blennow,et al.  Cerebrospinal Fluid Beta-Amyloid 42 Is Reduced before the Onset of Sporadic Dementia: A Population-Based Study in 85-Year-Olds , 2003, Dementia and Geriatric Cognitive Disorders.

[282]  T. Hwang Neuropsychiatric symptoms of mild cognitive impairment , 2003 .

[283]  J. Schneider,et al.  Relation of cerebral infarctions to dementia and cognitive function in older persons , 2003, Neurology.

[284]  S. Riedel-Heller,et al.  Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria , 2003, British Journal of Psychiatry.

[285]  Charles J Duffy,et al.  A visuospatial variant of mild cognitive impairment , 2003, Neurology.

[286]  R. Camicioli,et al.  Natural history of cognitive decline in the old old , 2003, Neurology.

[287]  Trey Sunderland,et al.  Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. , 2003, JAMA.

[288]  Kaj Blennow,et al.  Cerebrospinal fluid biomarkers for disease stage and intensity in cognitively impaired patients , 2003, Neuroscience Letters.

[289]  J. Baron,et al.  Mild cognitive impairment , 2003, Neurology.

[290]  S. D. Preston,et al.  Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid β from the human brain , 2003, Neuropathology and applied neurobiology.

[291]  Louise Nygård,et al.  Instrumental activities of daily living: a stepping‐stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment? , 2003, Acta neurologica Scandinavica. Supplementum.

[292]  E. Tangalos,et al.  Mild cognitive impairment in the oldest old , 2003, Neurology.

[293]  J. Touchon,et al.  Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study , 2003, Acta psychiatrica Scandinavica.

[294]  B. Winblad,et al.  Detection of Alzheimer's disease and dementia in the preclinical phase: population based cohort study , 2003, BMJ : British Medical Journal.

[295]  N. Herrmann,et al.  Contribution of Informant and Patient Ratings to the Accuracy of the Mini‐Mental State Examination in Predicting Probable Alzheimer's Disease , 2003, Journal of the American Geriatrics Society.

[296]  H. Tuokko,et al.  Five-year follow-up of cognitive impairment with no dementia. , 2003, Archives of neurology.

[297]  A. Drzezga,et al.  Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[298]  K. Sartor,et al.  [Current use and possible future applications of the magnetization transfer technique in neuroradiology]. , 2004, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[299]  Philip Scheltens,et al.  Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment , 2004, Neurology.

[300]  F. Hentschel,et al.  Leistet die Magnetization-Transfer-Ratio (MTR) einen Beitrag zur Diagnostik und Differenzialdiagnostik der Demenzen? , 2004 .

[301]  P. Visser Diagnosis of Predementia AD in a Clinical Setting , 2004 .

[302]  P. Scheltens,et al.  Advances in the early detection of Alzheimer's disease , 2004, Nature Reviews Neuroscience.

[303]  C. Jack,et al.  Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment , 2004, Journal of internal medicine.

[304]  H. Soininen,et al.  Incidence and Risk Factors for Mild Cognitive Impairment: A Population-Based Three-Year Follow-Up Study of Cognitively Healthy Elderly Subjects , 2004, Dementia and Geriatric Cognitive Disorders.

[305]  S. Gauthier Pharmacotherapy of mild cognitive impairment , 2004, Dialogues in clinical neuroscience.

[306]  K. Ritchie Mild cognitive impairment: an epidemiological perspective , 2004, Dialogues in clinical neuroscience.

[307]  Katharina Buerger,et al.  Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study. , 2004, Archives of general psychiatry.

[308]  S. DeKosky,et al.  Mild cognitive impairment, amnestic type , 2004, Neurology.

[309]  Nick C. Fox,et al.  Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease , 2004, NeuroImage.

[310]  K. Jellinger Alzheimer's changes in non-demented and demented patients , 2004, Acta Neuropathologica.

[311]  J. Sadavoy Comprehensive textbook of geriatric psychiatry , 2004 .

[312]  B. Reisberg,et al.  Vascular cognitive impairment , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[313]  Simon Lovestone,et al.  Is MCI really just early dementia? A systematic review of conversion studies , 2004, International Psychogeriatrics.

[314]  P. Hof,et al.  Neuropathological changes in the cerebral cortex of 1258 cases from a geriatric hospital: retrospective clinicopathological evaluation of a 10-year autopsy population , 1994, Acta Neuropathologica.

[315]  H. Arai,et al.  Cerebrospinal fluid tau protein and periventricular white matter lesions in patients with mild cognitive impairment: implications for 2 major pathways. , 2004, Archives of neurology.

[316]  Matthias J. Müller,et al.  Ultrastructural Hippocampal and White Matter Alterations in Mild Cognitive Impairment: A Diffusion Tensor Imaging Study , 2004, Dementia and Geriatric Cognitive Disorders.

[317]  S. Chantal,et al.  Similar 1H magnetic resonance spectroscopic metabolic pattern in the medial temporal lobes of patients with mild cognitive impairment and Alzheimer disease , 2004, Brain Research.

[318]  P. Scheltens,et al.  Behavioral symptoms in mild cognitive impairment , 2004, Neurology.

[319]  E. Feskens,et al.  Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men , 1995, Diabetologia.

[320]  R. Petersen Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[321]  H. Möller,et al.  Value of CSF β-amyloid1–42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment , 2004, Molecular Psychiatry.

[322]  M. Ball Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study , 1978, Acta Neuropathologica.

[323]  M. Albert,et al.  Amnestic MCI or prodromal Alzheimer's disease? , 2004, The Lancet Neurology.

[324]  H. Braak,et al.  Neuropathological stageing of Alzheimer-related changes , 2004, Acta Neuropathologica.

[325]  J. Ulrich,et al.  Alzheimer's changes in non-demented and demented patients: a statistical approach to their relationships , 2004, Acta Neuropathologica.

[326]  C. Jack,et al.  Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. , 2004, Archives of neurology.

[327]  E. John,et al.  Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment , 2005, Neurobiology of Aging.

[328]  S. Bandinelli,et al.  Insulin resistance in cognitive impairment: the InCHIANTI study. , 2005, Archives of Neurology.

[329]  M. Maj Early detection and management of mental disorders , 2005 .

[330]  L. Schneider Mild cognitive impairment. , 2005, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[331]  J. Poirier,et al.  CHOLESTEROL TRANSPORT AND SYNTHESIS IN SPORADIC ALZHEIMER'S DISEASE , 2005 .

[332]  J. Cummings,et al.  The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[333]  S. Leurgans,et al.  MRI predictors of risk of incident Alzheimer disease , 2005, Neurology.

[334]  J. Schneider,et al.  Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions , 2005, Neurology.

[335]  N. Schuff,et al.  Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. , 2005, Radiology.

[336]  M. Leon,et al.  Subjective memory complaints in aging are associated with elevated cortisol levels , 2005, Neurobiology of Aging.

[337]  N. Herrmann,et al.  Mild Cognitive Impairment: An Operational Definition and Its Conversion Rate to Alzheimer’s Disease , 2005, Dementia and Geriatric Cognitive Disorders.

[338]  P. Scheltens,et al.  Alzheimer's Disease and Related Disorders , 2005 .

[339]  Giovanni B. Frisoni,et al.  Distinctive Clinical Features of Mild Cognitive Impairment with Subcortical Cerebrovascular Disease , 2005, Dementia and Geriatric Cognitive Disorders.

[340]  C. Reynolds,et al.  Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment , 2005, International journal of geriatric psychiatry.

[341]  P. Whitehouse,et al.  Antiaging Medicine and Mild Cognitive Impairment: Practice and Policy Issues for Geriatrics , 2005, Journal of the American Geriatrics Society.

[342]  D. Blacker Mild cognitive impairment--no benefit from vitamin E, little from donepezil. , 2005, The New England journal of medicine.

[343]  F. Hu,et al.  Plasma C peptide level and cognitive function among older women without diabetes mellitus. , 2005, Archives of internal medicine.

[344]  M. Bobinski,et al.  Hippocampal atrophy in early Alzheimer's Disease: Anatomic specificity and validation , 2005, Psychiatric Quarterly.

[345]  P. Visser,et al.  Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer’s disease? , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[346]  P. Rabins Comprehensive Textbook of Geriatric Psychiatry, 3rd ed. , 2005 .

[347]  D. Bennett,et al.  The apolipoprotein E ϵ4 allele and incident Alzheimer’s disease in persons with mild cognitive impairment , 2005 .

[348]  D. Auer,et al.  Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease , 2005, Neuroscience Letters.

[349]  J. Morris,et al.  Mild cognitive impairment as a clinical entity and treatment target. , 2005, Archives of neurology.

[350]  Judes Poirier,et al.  Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease , 2005, Neurobiology of Aging.

[351]  M. Zaudig The Prodromes and Early Detection of Alzheimer's Disease , 2005 .

[352]  S. Gauthier,et al.  Mild cognitive impairment is not a clinical entity and should not be treated. , 2005, Archives of neurology.

[353]  N. Fayed,et al.  Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopy. , 2005, The American journal of psychiatry.

[354]  R. Basha,et al.  The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain , 2005, The Journal of Neuroscience.

[355]  D. Bennett,et al.  Vitamin E and donepezil for the treatment of mild cognitive impairment. , 2005, The New England journal of medicine.

[356]  Patrizia Mecocci,et al.  Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy , 2006, Neurobiology of Aging.

[357]  Heinz-Otto Peitgen,et al.  Diffusion tensor imaging in primary brain tumors: Reproducible quantitative analysis of corpus callosum infiltration and contralateral involvement using a probabilistic mixture model , 2006, NeuroImage.

[358]  F. Jessen,et al.  Treatment monitoring and response prediction with proton MR spectroscopy in AD , 2006, Neurology.

[359]  Matthias J. Müller,et al.  Predicting conversion to dementia in mild cognitive impairment by volumetric and diffusivity measurements of the hippocampus , 2006, Psychiatry Research: Neuroimaging.

[360]  T. Kirkwood Alzheimer's Disease, Mild Cognitive Impairment, and the Biology of Intrinsic Aging , 2006 .

[361]  D. Bennett,et al.  Mild cognitive impairment , 2006, Neurology.

[362]  M. Bavidge Under the Floorboards: Examining the Foundations of Mild Cognitive Impairment , 2006 .

[363]  J. Helpern,et al.  Quantitative MR imaging in Alzheimer disease. , 2006, Radiology.

[364]  Taylor W. Schmitz,et al.  Structural MRI discriminates individuals with Mild Cognitive Impairment from age-matched controls: A combined neuropsychological and voxel based morphometry study , 2006, Alzheimer's & Dementia.

[365]  Daniel Rueckert,et al.  Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data , 2006, NeuroImage.

[366]  Shi-Jiang Li,et al.  Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects , 2007, Neurology.

[367]  K. Kantarci 1H magnetic resonance spectroscopy in dementia. , 2007, The British journal of radiology.

[368]  M. J. Leon,et al.  Longitudinal CSF isoprostane and MRI atrophy in the progression to AD , 2007, Journal of Neurology.

[369]  R. Prost,et al.  Proton Magnetic Resonance Spectroscopy of the Hippocampus in Patients With Mild Cognitive Impairment: A Pilot Study , 2007, Journal of computer assisted tomography.

[370]  Clifford R. Jack,et al.  Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease , 2007, Neurobiology of Aging.

[371]  H. Olofsen,et al.  Lobar Distribution of Changes in Gray Matter and White Matter in Memory Clinic Patients: Detected Using Magnetization Transfer Imaging , 2007, American Journal of Neuroradiology.

[372]  R. Cohen The Application of Positron-Emitting Molecular Imaging Tracers in Alzheimer’s Disease , 2007, Molecular Imaging and Biology.