Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor–treated APP transgenic mice

[1]  Sandra E. Black,et al.  Vascular cognitive impairment , 2018, Nature Reviews Disease Primers.

[2]  M. Staufenbiel,et al.  A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice , 2015, Molecular Neurodegeneration.

[3]  E. Liu,et al.  Amyloid-related imaging abnormalities-haemosiderin (ARIA-H) in patients with Alzheimer's disease treated with bapineuzumab: a historical, prospective secondary analysis , 2015, Journal of Neurology, Neurosurgery & Psychiatry.

[4]  C. Holmes,et al.  Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy , 2014, Acta Neuropathologica.

[5]  M. Staufenbiel,et al.  Multiple Factors Contribute to the Peripheral Induction of Cerebral β-Amyloidosis , 2014, The Journal of Neuroscience.

[6]  Olivier Salvado,et al.  Incidence of cerebral microbleeds in preclinical Alzheimer disease , 2014, Neurology.

[7]  M. Rudin,et al.  Imaging of cerebrovascular pathology in animal models of Alzheimer's disease , 2014, Front. Aging Neurosci..

[8]  Alexander Leemans,et al.  Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.

[9]  L. Maffei,et al.  Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice , 2013, Front. Aging Neurosci..

[10]  P. Seubert,et al.  Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities , 2013, Alzheimer's & Dementia.

[11]  C. Jack,et al.  Focal hemosiderin deposits and β-amyloid load in the ADNI cohort , 2013, Alzheimer's & Dementia.

[12]  Christine Egger,et al.  Administration of Bleomycin via the Oropharyngeal Aspiration Route Leads to Sustained Lung Fibrosis in Mice and Rats as Quantified by UTE-MRI and Histology , 2013, PloS one.

[13]  D. Werring,et al.  Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment , 2013, Annals of neurology.

[14]  M. Sabbagh,et al.  Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy , 2013, PloS one.

[15]  W. M. van der Flier.  Clinical aspects of microbleeds in Alzheimer's disease , 2012, Journal of the Neurological Sciences.

[16]  D. Llano,et al.  Characterization of 7- and 19-month-old Tg2576 mice using multimodal in vivo imaging: limitations as a translatable model of Alzheimer's disease , 2012, Neurobiology of Aging.

[17]  Nick C Fox,et al.  Brain imaging in Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[18]  T. Matsuguchi,et al.  Bleomycin‐induced lung injury in mice investigated by MRI: Model assessment for target analysis , 2012, Magnetic resonance in medicine.

[19]  V L Villemagne,et al.  Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease , 2011, Neurology.

[20]  Clifford R. Jack,et al.  Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup , 2011, Alzheimer's & Dementia.

[21]  B. Hyman,et al.  T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice , 2011, Molecular Neurodegeneration.

[22]  S. Greenberg,et al.  Cerebral Amyloid Angiopathy: A Systematic Review , 2011, Journal of clinical neurology.

[23]  M. Staufenbiel,et al.  Noninvasive Magnetic Resonance Imaging Detection of Cerebral Amyloid Angiopathy-Related Microvascular Alterations Using Superparamagnetic Iron Oxide Particles in APP Transgenic Mouse Models of Alzheimer's Disease: Application to Passive Aβ Immunotherapy , 2011, The Journal of Neuroscience.

[24]  Brad J Kolls,et al.  A PHASE 2 MULTIPLE ASCENDING DOSE TRIAL OF BAPINEUZUMAB IN MILD TO MODERATE ALZHEIMER DISEASE , 2010, Neurology.

[25]  V. Dousset,et al.  In vivo visualization of macrophage infiltration and activity in inflammation using magnetic resonance imaging. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[26]  R O Weller,et al.  Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. , 2008, Brain : a journal of neurology.

[27]  Dietmar Rudolf Thal,et al.  Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease , 2008, Acta Neuropathologica.

[28]  Johannes Kornhuber,et al.  Therapeutic approaches to Alzheimer's disease. , 2006, Brain : a journal of neurology.

[29]  D. Quartermain,et al.  Vaccination of Alzheimer's model mice with Aβ derivative in alum adjuvant reduces Aβ burden without microhemorrhages , 2006, The European journal of neuroscience.

[30]  E. Englund,et al.  Differential deposition of amyloid β peptides in cerebral amyloid angiopathy associated with Alzheimer’s disease and vascular dementia , 2006, Acta Neuropathologica.

[31]  M. Frosch,et al.  The Cerebral β‐Amyloid Angiopathies: Hereditary and Sporadic , 2006 .

[32]  T. Golde,et al.  Anti-Aβ42– and anti-Aβ40–specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model , 2005 .

[33]  Nick C Fox,et al.  Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial , 2005, Neurology.

[34]  W. H. Jordan,et al.  Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β , 2005, The Journal of Neuroscience.

[35]  L. Jenkins,et al.  Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD , 2005, Neurology.

[36]  D. Wilcock,et al.  Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage , 2004, Journal of Neuroinflammation.

[37]  Eric E. Smith,et al.  Hemorrhage Burden Predicts Recurrent Intracerebral Hemorrhage After Lobar Hemorrhage , 2004, Stroke.

[38]  R. Weller,et al.  Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer’s disease Pro-CAA position statement , 2004, Neurobiology of Aging.

[39]  M. Frosch,et al.  Clinical manifestations of cerebral amyloid angiopathy–related inflammation , 2004, Annals of neurology.

[40]  I. Ferrer,et al.  Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease , 2004, Brain pathology.

[41]  B. Dubois,et al.  Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization , 2003, Neurology.

[42]  C. Holmes,et al.  Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report , 2003, Nature Medicine.

[43]  K. Jellinger,et al.  Alzheimer disease and cerebrovascular pathology: an update , 2002, Journal of Neural Transmission.

[44]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[45]  M. Staufenbiel,et al.  Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy , 2001, The Journal of Neuroscience.

[46]  M. Staufenbiel,et al.  Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model , 2000, Annals of the New York Academy of Sciences.

[47]  Masahito Yamada,et al.  Cerebral amyloid angiopathy: An overview , 2000, Neuropathology : official journal of the Japanese Society of Neuropathology.

[48]  B. Sommer,et al.  Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[49]  B. Sommer,et al.  Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[50]  S. Younkin,et al.  Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). , 1995, The Journal of biological chemistry.

[51]  G. Perry,et al.  Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease , 1993, Brain Research.

[52]  T. Miyatake,et al.  Cerebral amyloid angiopathy: A significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly , 1993, Journal of Neurological Sciences.

[53]  H. Vinters.  Cerebral amyloid angiopathy. A critical review. , 1987, Stroke.

[54]  M. Tomonaga,et al.  Cerebral Amyloid Angiopathy in the Elderly , 1981, Journal of the American Geriatrics Society.

[55]  Peter R Luijten,et al.  High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease. , 2012, Journal of Alzheimer's disease : JAD.

[56]  T. Golde,et al.  Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. , 2006, The Journal of clinical investigation.

[57]  M. Frosch,et al.  The cerebral beta-amyloid angiopathies: hereditary and sporadic. , 2006, Brain pathology.

[58]  D. Quartermain,et al.  Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages. , 2006, The European journal of neuroscience.

[59]  Vladimir V. Frolkis,et al.  Neurobiology of Aging , 2019, Psychobiology of Behaviour.

[60]  M. Staufenbiel,et al.  Cerebral hemorrhage after passive anti-Abeta immunotherapy. , 2002, Science.

[61]  M. Staufenbiel,et al.  Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid. , 1996, Journal of neuroscience research.