Depression and voice handicap in Parkinson disease

BACKGROUND Dysphonia is common in Parkinson's disease (PD), but the mechanism underlying the development remains unclear. This study investigated possible clinical factors related to PD dysphonia. METHODS Dysphonia severity was assessed in 147 non-demented patients with PD and 30 non-PD controls using the Voice Handicap Index (VHI)-10. A threshold of 12 VHI-10 score was used to define the presence of dysphonia. The severity of PD and depression was measured using the Unified Parkinson's Disease Rating Scale (UPDRS)-motor and the Geriatric Depression Scale (GDS). RESULTS Dysphonia was observed in 52 patients (35.4%). Patients with dysphonia scored higher on the UPDRS and GDS scores compared with patients without dysphonia. Multivariate logistic regression analysis revealed that GDS was the only factor significantly associated with the presence of dysphonia. Non-PD controls did not show this association. CONCLUSIONS The results support a high prevalence of dysphonia in patients with PD, and suggest that the presence of dysphonia is more closely related to depression than to the severity of PD.

[1]  I. Midi,et al.  Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease , 2007, Acta neurologica Scandinavica.

[2]  Kenichi Komatsu,et al.  Depression in Parkinson’s disease , 2007, Journal of Neurology.

[3]  John L Bradshaw,et al.  For better or worse: The effect of levodopa on speech in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[4]  Robert Iansek,et al.  Volume perception in Parkinsonian speech , 2000, Movement disorders : official journal of the Movement Disorder Society.

[5]  Jackie L. Gartner-Schmidt,et al.  Normative values for the Voice Handicap Index-10. , 2012, Journal of voice : official journal of the Voice Foundation.

[6]  Uwe Walter,et al.  Parkinson's disease-like midbrain sonography abnormalities are frequent in depressive disorders. , 2007, Brain : a journal of neurology.

[7]  J. Hughes,et al.  Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[8]  L. Ramig,et al.  Speech and swallowing disorders in Parkinson disease , 2008, Current opinion in otolaryngology & head and neck surgery.

[9]  D. Aarsland,et al.  A systematic review of prevalence studies of dementia in Parkinson's disease , 2005, Movement disorders : official journal of the Movement Disorder Society.

[10]  Thomas Murry,et al.  Development and Validation of the Voice Handicap Index‐10 , 2004, The Laryngoscope.

[11]  R G Robinson,et al.  Depression in Parkinson's Disease , 1990, The Journal of nervous and mental disease.

[12]  I. Cobeta,et al.  Acoustic voice analysis in patients with Parkinson's disease treated with dopaminergic drugs. , 1997, Journal of voice : official journal of the Voice Foundation.

[13]  C. Brayne,et al.  A systematic review of depression and mental illness preceding Parkinson's disease , 2006, Acta neurologica Scandinavica.

[14]  Anette Schrag,et al.  Quality of life and depression in Parkinson's disease , 2006, Journal of the Neurological Sciences.

[15]  P. Barone,et al.  Dopamine receptor agonists and depression in Parkinson's disease. , 2009, Parkinsonism & related disorders.

[16]  J A Yesavage,et al.  Geriatric Depression Scale. , 1988, Psychopharmacology bulletin.

[17]  F Lhermitte,et al.  Does long‐term aggravation of Parkinson's disease result from nondopaminergic lesions? , 1987, Neurology.

[18]  Dag Aarsland,et al.  Depression in Parkinson disease—epidemiology, mechanisms and management , 2011, Nature Reviews Neurology.

[19]  Masoud Salehi,et al.  Relation between Voice Handicap Index (VHI) and disease severity in Iranian patients with Parkinson's disease , 2012, Medical journal of the Islamic Republic of Iran.

[20]  L. Hartelius,et al.  Speech and swallowing symptoms associated with Parkinson's disease and multiple sclerosis: a survey. , 1994, Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics.

[21]  M Filippi,et al.  Regional patterns of brain tissue loss associated with depression in Parkinson disease , 2010, Neurology.

[22]  Canan Ozsancak,et al.  Treatments for dysarthria in Parkinson's disease , 2004, The Lancet Neurology.

[23]  J. Jankovic,et al.  Variable expression of Parkinson's disease , 1990, Neurology.

[24]  T. Pring,et al.  Self-perception of speech changes in patients with Parkinson's disease following deep brain stimulation of the subthalamic nucleus , 2010, International journal of speech-language pathology.

[25]  S. Skodda,et al.  Progression of dysprosody in Parkinson's disease over time—A longitudinal study , 2009, Movement disorders : official journal of the Movement Disorder Society.

[26]  Nick Miller,et al.  Intelligibility of dysarthric speech: perceptions of speakers and listeners. , 2008, International journal of language & communication disorders.

[27]  S. Skodda,et al.  Short- and long-term dopaminergic effects on dysarthria in early Parkinson’s disease , 2010, Journal of Neural Transmission.

[28]  R. D. de Haan,et al.  Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD , 2004, Neurology.

[29]  D. Aarsland,et al.  A systematic review of prevalence studies of depression in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.