Telomeres in T and B cells

[1]  Margaret A. Strong,et al.  Haploinsufficiency of mTR results in defects in telomere elongation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[2]  T. Lange Protection of mammalian telomeres , 2002, Oncogene.

[3]  Margaret A. Strong,et al.  The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability , 2001, Cell.

[4]  T. Vulliamy,et al.  The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita , 2001, Nature.

[5]  E. Blackburn Switching and Signaling at the Telomere , 2001, Cell.

[6]  N. Rufer,et al.  Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. , 2001, Blood.

[7]  P. Baumann,et al.  Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans , 2001, Science.

[8]  I. Weissman,et al.  Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem Cells , 2001, The Journal of experimental medicine.

[9]  Kebin Liu,et al.  Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation , 2001, The Journal of Immunology.

[10]  M. Salmon,et al.  The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection. , 2001, Blood.

[11]  M. Salmon,et al.  Differential regulation of CD8+ T cell senescence in mice and men , 2001, Mechanisms of Ageing and Development.

[12]  Erik Hooijberg,et al.  Immortalization of Human CD8+ T Cell Clones by Ectopic Expression of Telomerase Reverse Transcriptase1 , 2000, The Journal of Immunology.

[13]  R. Hodes,et al.  Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age , 2000, The Journal of Immunology.

[14]  J. Shay,et al.  Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology , 2000, Nature Medicine.

[15]  J. Shay,et al.  Transient expression of human telomerase extends the life span of normal human fibroblasts. , 2000, Biochemical and biophysical research communications.

[16]  Matthias Mann,et al.  Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres , 2000, Nature Genetics.

[17]  T. von Zglinicki,et al.  Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence , 2000, Annals of the New York Academy of Sciences.

[18]  M. Blasco,et al.  Impaired germinal center reaction in mice with short telomeres , 2000, The EMBO journal.

[19]  E. Blackburn,et al.  Telomeres and their control. , 2000, Annual review of genetics.

[20]  K. Collins,et al.  A telomerase component is defective in the human disease dyskeratosis congenita , 1999, Nature.

[21]  E. Blackburn,et al.  Ku is associated with the telomere in mammals. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Nathalie Rufer,et al.  Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood , 1999, The Journal of experimental medicine.

[23]  J. Griffith,et al.  Mammalian Telomeres End in a Large Duplex Loop , 1999, Cell.

[24]  M. Maini,et al.  Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence. , 1999, Journal of immunology.

[25]  Sandy Chang,et al.  Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice , 1999, Cell.

[26]  D. Broccoli,et al.  p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. , 1999, Science.

[27]  R. Hodes,et al.  Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential. , 1998, Immunity.

[28]  M. Seldin,et al.  Telomere length regulation in mice is linked to a novel chromosome locus. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Jenkins,et al.  Cutting edge: antigen-dependent regulation of telomerase activity in murine T cells. , 1998, Journal of immunology.

[30]  E. Blackburn,et al.  The rate of telomere sequence loss in human leukocytes varies with age. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  R. DePinho,et al.  Essential role of mouse telomerase in highly proliferative organs , 1998, Nature.

[32]  J. Shay,et al.  Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals , 1998, Human Genetics.

[33]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[34]  P. Lansdorp,et al.  Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry , 1998, Nature Biotechnology.

[35]  B. Levine,et al.  Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging , 1997, Immunological reviews.

[36]  R. Reddel,et al.  Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines , 1997, Nature Medicine.

[37]  María A Blasco,et al.  Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA , 1997, Cell.

[38]  R. Hodes,et al.  Telomere lengthening and telomerase activation during human B cell differentiation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[39]  R. Weinberg,et al.  hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization , 1997, Cell.

[40]  C B Harley,et al.  Telomerase catalytic subunit homologs from fission yeast and human. , 1997, Science.

[41]  R. Insel,et al.  Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro. , 1997, Journal of immunology.

[42]  H. Tanke,et al.  Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Niels Schaft,et al.  T cell telomere length in HIV-1 infection: No evidence for increased CD4+ T cell turnover☆ , 1997 .

[44]  H. Lane,et al.  Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins , 1997, The Journal of experimental medicine.

[45]  Bas van Steensel,et al.  Control of telomere length by the human telomeric protein TRF1 , 1997, Nature.

[46]  H. Igarashi,et al.  Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor. , 1997, Blood.

[47]  A. Takashima,et al.  Mechanisms regulating telomerase activity in murine T cells. , 1997, Journal of immunology.

[48]  June Corwin,et al.  Telomerase Catalytic Subunit Homologs from Fission Yeast and Human , 1997 .

[49]  Niels Schaft,et al.  T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover , 1996, Science.

[50]  G. Pawelec,et al.  Lifespans of T lymphocytes , 1996, Mechanisms of Ageing and Development.

[51]  R. Effros,et al.  Mechanism of telomerase induction during T cell activation. , 1996, Experimental cell research.

[52]  I. Weissman,et al.  Telomerase activity in hematopoietic cells is associated with self-renewal potential. , 1996, Immunity.

[53]  G. Roos,et al.  Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas , 1996 .

[54]  C. Harley,et al.  Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. , 1996, AIDS.

[55]  B. Levine,et al.  Regulated expression of telomerase activity in human T lymphocyte development and activation , 1996, The Journal of experimental medicine.

[56]  H. Ostrer,et al.  Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. , 1996, Journal of immunology.

[57]  C. Greider,et al.  Telomere length regulation. , 1996, Annual review of biochemistry.

[58]  G. Roos,et al.  Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas. , 1996, Blood.

[59]  B L Levine,et al.  Human naive and memory T lymphocytes differ in telomeric length and replicative potential. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[60]  J. Shay,et al.  Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. , 1995, Journal of immunology.

[61]  M. Blasco,et al.  Functional characterization and developmental regulation of mouse telomerase RNA , 1995, Science.

[62]  et al.,et al.  The RNA component of human telomerase , 1995, Science.

[63]  G. Kelsoe In situ studies of the germinal center reaction. , 1995, Advances in immunology.

[64]  C B Harley,et al.  Specific association of human telomerase activity with immortal cells and cancer. , 1994, Science.

[65]  D I Boomsma,et al.  Genetic determination of telomere size in humans: a twin study of three age groups. , 1994, American journal of human genetics.

[66]  C B Harley,et al.  Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[67]  C B Harley,et al.  Telomere length predicts replicative capacity of human fibroblasts. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[68]  C. Harley,et al.  Telomeres shorten during ageing of human fibroblasts , 1990, Nature.

[69]  I. Maclennan,et al.  Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones? , 1988, Immunology letters.

[70]  L. Hayflick THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. , 1965, Experimental cell research.