Assessment in rats of a new bioerodible bone-wax-like polymer.

Holes drilled in rats' skull, iliac crest, and tibia were filled with beeswax or with a new, wax-like, bioerodible polyorthoester (Alzamer). Empty drill-holes served as controls. In addition, beeswax and polyorthoester were deposited between the left and the right oblique abdominal muscles, respectively. In muscle, both the beeswax and polyorthoester elicited a transient foreign body reaction. The beeswax was not resorbed in bone or muscle, whereas the polyorthoester was. Bone healing was inhibited in the iliac crest and the tibiae filled with beeswax, whereas holes filled with polyorthoester healed readily.

[1]  E. Sudmann,et al.  Inhibition of heterotopic osteogenesis in rats by a new bioerodible system for local delivery of indomethacin. , 1992, The Journal of bone and joint surgery. American volume.

[2]  E. Sudmann,et al.  Fracture healing in rats inhibited by locally administered indomethacin. , 1992, Acta orthopaedica Scandinavica.

[3]  E. Sudmann,et al.  Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats. , 1991, Acta orthopaedica Scandinavica.

[4]  E. Sudmann,et al.  Effect of local hemostatics on platelet aggregation. , 1991, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[5]  J. Aurelio,et al.  Foreign-body reaction to bone wax. Report of a case. , 1984, Oral surgery, oral medicine, and oral pathology.

[6]  W. Cumming,et al.  Reaction of the Human Tibia to Bone Wax , 1984, Clinical orthopaedics and related research.

[7]  J. Heller,et al.  Release of norethindrone from poly(ortho esters) , 1981 .

[8]  G. Born,et al.  The Embolization of Bone Wax from Sternotomy Incisions , 1981 .

[9]  D. Fromm,et al.  Effects of bone wax on bacterial clearance. , 1981, Surgery.

[10]  L. Kinzl,et al.  [Reaction of the bone- and soft tissues to implanted bone wax in the sheep]. , 1975, Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen.

[11]  J. Humble,et al.  Haemostasis and healing following median sternotomy. , 1975, Langenbecks Archiv fur Chirurgie.

[12]  R. Kelley,et al.  The effect of bone wax on the healing of experimental rat tibial lesions. , 1969, Clinical orthopaedics and related research.

[13]  A. B. Carter.  Prognosis of Hysterical Symptoms , 1949 .

[14]  J. Priestley.  Scarlatina and Small-Pox , 1892 .

[15]  James Coles Parker,et al.  Chloroform as an Anæsthetic , 1892 .