Design and Implementation of an Enhanced Recovery After Surgery (ERAS) Program for Minimally Invasive Lumbar Decompression Spine Surgery: Initial Experience

Study Design. A retrospective cohort study of prospectively collected data. Objective. The aim of this study was to describe the development of and early experience with an evidence-based enhanced recovery after surgery (ERAS) pathway for lumbar decompression. Summary of Background Data. ERAS protocols have been consistently associated with improved patient experience and outcomes, and reduced cost and length of hospital stay (LoS). Despite successes in other orthopedic subspecialties, ERAS has yet to be established in spine surgery. Here, we report the development of and initial experience with the first comprehensive ERAS pathway for MIS lumbar spine surgery. Methods. An evidence-based review of the literature was performed to select components of the ERAS pathway. The pathway was applied to 61 consecutive patients presenting for microdiscectomy or lumbar laminotomy/laminectomy between dates. Data collection was performed by review of the electronic medical record. We evaluated compliance with individual ERAS process measures, and adherence to the overall pathway. The primary outcome was LoS. Demographics, comorbidities, perioperative course, prevalence of opioid tolerance, and factors affecting LoS were also documented. Results. The protocol included 15 standard ERAS elements. Overall pathway compliance was 85.03%. Median LoS was 279 minutes [interquartile range (IQR) 195–398 minutes] overall, 298 minutes (IQR 192–811) for lumbar decompression and 285 minutes (IQR 200–372) for microdiscectomy. There was no correlation between surgical subtype or duration and LoS. Overall, 37% of the cohort was opioid-tolerant at the time of surgery. There was no significant effect of baseline opioid use on LoS, or on the total amount of intraoperative or PACU opioid administration. There were four complications (6.5%) resulting in extended LoS (>23 hours). Conclusion. This report comprises the first description of a comprehensive, evidence-based ERAS for spine pathway, tailored for lumbar decompression/microdiscectomy resulting in short LoS, minimal complications, and no readmissions within 90 days of surgery. Level of Evidence: 3

[1]  M. Okano,et al.  Cohort Study , 2020, Definitions.

[2]  Pengfei Guo,et al.  A meta-analysis of randomized controlled trials , 2019, Medicine.

[3]  S. Farhan,et al.  Perioperative Ketamine for Analgesia in Spine Surgery: A Meta-analysis of Randomized Controlled Trials , 2018, Spine.

[4]  M. Yaszemski,et al.  Does Subcutaneous Infiltration of Liposomal Bupivacaine Following Single-Level Transforaminal Lumbar Interbody Fusion Surgery Improve Immediate Postoperative Pain Control? , 2018, Asian spine journal.

[5]  R. Fukushima,et al.  Enhanced Recovery after Surgery , 2018, Springer Singapore.

[6]  Christopher L. Wu,et al.  Dedicated Operating Room Teams and Clinical Outcomes in an Enhanced Recovery after Surgery Pathway for Colorectal Surgery. , 2017, Journal of the American College of Surgeons.

[7]  D. Messenger,et al.  The impact of enhanced recovery after surgery (ERAS) protocol compliance on morbidity from resection for primary lung cancer , 2017, The Journal of thoracic and cardiovascular surgery.

[8]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[9]  G. Liguori,et al.  An Evidence-Based Approach to the Prescription Opioid Epidemic in Orthopedic Surgery , 2017, Anesthesia and analgesia.

[10]  Kern Singh,et al.  Multimodal Analgesia Versus Intravenous Patient-Controlled Analgesia for Minimally Invasive Transforaminal Lumbar Interbody Fusion Procedures , 2017, Spine.

[11]  Olav A Foss,et al.  Mortality and readmission following hip fracture surgery: a retrospective study comparing conventional and fast-track care , 2017, BMJ Open.

[12]  Michael Y. Wang,et al.  Development of an Enhanced Recovery After Surgery (ERAS) approach for lumbar spinal fusion. , 2017, Journal of neurosurgery. Spine.

[13]  K. Fearon,et al.  Enhanced Recovery After Surgery: A Review , 2017, JAMA surgery.

[14]  M. Alimi,et al.  Lumbar Spinal Stenosis Associated With Degenerative Lumbar Spondylolisthesis: A Systematic Review and Meta-analysis of Secondary Fusion Rates Following Open vs Minimally Invasive Decompression , 2017, Neurosurgery.

[15]  M. Trivella,et al.  Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain. , 2017, The Cochrane database of systematic reviews.

[16]  J. Yadeau,et al.  Enhanced recovery after surgery for primary hip and knee arthroplasty: a review of the evidence. , 2016, British journal of anaesthesia.

[17]  M. Bydon,et al.  Liposomal bupivacaine incisional injection in single-level lumbar spine surgery. , 2016, The spine journal : official journal of the North American Spine Society.

[18]  S. Giannone,et al.  Goal-Directed Fluid Therapy Based on Stroke Volume Variation in Patients Undergoing Major Spine Surgery in the Prone Position: A Cohort Study , 2016, Spine.

[19]  T. Wainwright,et al.  Enhanced recovery after surgery: An opportunity to improve fractured neck of femur management. , 2016, Annals of the Royal College of Surgeons of England.

[20]  O. Kanbak,et al.  Sedation Monitoring and Management during Percutaneous Endoscopic Lumbar Discectomy , 2016, Case reports in anesthesiology.

[21]  Roger Chou,et al.  CDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016. , 2016, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[22]  R. Mobbs,et al.  Minimally Invasive Versus Open Laminectomy for Lumbar Stenosis: A Systematic Review and Meta-Analysis , 2016, Spine.

[23]  H. Kehlet,et al.  Challenges in postdischarge function and recovery: the case of fast-track hip and knee arthroplasty. , 2015, British journal of anaesthesia.

[24]  D. McMillan,et al.  Enhanced Recovery After Surgery: Which Components, If Any, Impact on The Systemic Inflammatory Response Following Colorectal Surgery? , 2015, Medicine.

[25]  M. McGirt,et al.  Best evidence in multimodal pain management in spine surgery and means of assessing postoperative pain and functional outcomes , 2015, Journal of Clinical Neuroscience.

[26]  Kyung-Hoon Kim Safe Sedation and Hypnosis using Dexmedetomidine for Minimally Invasive Spine Surgery in a Prone Position , 2014, The Korean journal of pain.

[27]  G. P. Herbison,et al.  Preoperative carbohydrate treatment for enhancing recovery after elective surgery. , 2014, The Cochrane database of systematic reviews.

[28]  M. Page,et al.  Preoperative education for hip or knee replacement. , 2014, The Cochrane database of systematic reviews.

[29]  N. Epstein A review article on the benefits of early mobilization following spinal surgery and other medical/surgical procedures , 2014, Surgical neurology international.

[30]  S. Bergese,et al.  Consensus Guidelines for the Management of Postoperative Nausea and Vomiting , 2014, Anesthesia and analgesia.

[31]  B. Ran,et al.  Gabapentin and Pregabalin in the Management of Postoperative Pain After Lumbar Spinal Surgery: A Systematic Review and Meta-analysis , 2013, Spine.

[32]  J. Pergolizzi,et al.  Intravenous acetaminophen reduces postoperative nausea and vomiting: A systematic review and meta-analysis , 2013, PAIN®.

[33]  F. Carli,et al.  Guidelines for Perioperative Care in Elective Rectal/Pelvic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations , 2013, World Journal of Surgery.

[34]  F. Martiniuk,et al.  The Effect of Intraoperative Infusion of Dexmedetomidine on the Quality of Recovery After Major Spinal Surgery , 2013, Journal of neurosurgical anesthesiology.

[35]  F. Carli,et al.  Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. , 2012, Clinical nutrition.

[36]  J. Macfie,et al.  Enhanced recovery after surgery protocols – compliance and variations in practice during routine colorectal surgery , 2012, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[37]  P. Kranke,et al.  Transdermal scopolamine for the prevention of postoperative nausea and vomiting: a systematic review and meta-analysis. , 2010, Clinical therapeutics.

[38]  Jeffrey G Jarvik,et al.  Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. , 2010, JAMA.

[39]  K. Lassen,et al.  A protocol is not enough to implement an enhanced recovery programme for colorectal resection , 2007, The British journal of surgery.

[40]  R. Deyo,et al.  Trends and variations in the use of spine surgery. , 2006, Clinical orthopaedics and related research.

[41]  R. Deyo,et al.  United States Trends in Lumbar Fusion Surgery for Degenerative Conditions , 2005, Spine.

[42]  J. Guest,et al.  Mild hypothermia, blood loss and complications in elective spinal surgery. , 2004, The spine journal : official journal of the North American Spine Society.

[43]  F. Barker Efficacy of Prophylactic Antibiotic Therapy in Spinal Surgery: A Meta-analysis , 2002, Neurosurgery.

[44]  H. Kehlet Multimodal approach to control postoperative pathophysiology and rehabilitation. , 1997 .

[45]  F. Lauzier,et al.  Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials , 2011, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[46]  H. McQuay,et al.  Meta-analysis of single dose oral tramadol plus acetaminophen in acute postoperative pain. , 2003, European journal of anaesthesiology. Supplement.