"Sign-on/off" sensing interface design and fabrication for propyl gallate recognition and sensitive detection.

A new strategy based on sign-on and sign-off was proposed for propyl gallate (PG) determination by an electrochemical sensor. The successively modified poly(thionine) (PTH) and molecular imprinted polymer (MIP) showed an obvious electrocatalysis and a good recognition toward PG, respectively. Furthermore, the rebound PG molecules in imprinted cavities not only were oxidized but also blocked the electron transmission channels for PTH redox. Thus, a sign-on from PG current and a sign-off from PTH current were combined as a dual-sign for PG detection. Meanwhile, the modified MIP endowed the sensor with recognition capacity. The electrochemical experimental results demonstrated that the prepared sensor possessed good selectivity and high sensitivity. A linear ranging from 5.0×10(-8) to 1.0×10(-4)mol/L for PG detection was obtained with a limit of detection of 2.4×10(-8)mol/L. And the sensor has been applied to analyze PG in real samples with satisfactory results. The simple, low cost, and effective strategy reported here can be further used to prepare electrochemical sensors for other compounds selective recognition and sensitive detection.

[1]  Klaus Mosbach,et al.  Drug assay using antibody mimics made by molecular imprinting , 1993, Nature.

[2]  Mohamed M. Chehimi,et al.  Nanocomposites of Gold Nanoparticles@Molecularly Imprinted Polymers: Chemistry, Processing, and Applications in Sensors , 2015 .

[3]  Yaoyu Cao,et al.  Prussian blue mediated amplification combined with signal enhancement of ordered mesoporous carbon for ultrasensitive and specific quantification of metolcarb by a three-dimensional molecularly imprinted electrochemical sensor. , 2015, Biosensors & bioelectronics.

[4]  Prashant K. Sharma,et al.  Introduction of selectivity and specificity to graphene using an inimitable combination of molecular imprinting and nanotechnology. , 2017, Biosensors & bioelectronics.

[5]  Dermot Diamond,et al.  Development of a biosensor for endocrine disrupting compounds based on tyrosinase entrapped within a poly(thionine) film. , 2004, Biosensors & bioelectronics.

[6]  Rong Zhang,et al.  Highly sensitive glucose sensor based on pt nanoparticle/polyaniline hydrogel heterostructures. , 2013, ACS nano.

[7]  Lingxin Chen,et al.  Novel Pb2+ ion imprinted polymers based on ionic interaction via synergy of dual functional monomers for selective solid-phase extraction of Pb2+ in water samples. , 2014, ACS applied materials & interfaces.

[8]  L. Fu,et al.  Determination of phenolic antioxidants by micellar electrokinetic capillary chromatography with electrochemical detection , 2006 .

[9]  Yu Wang,et al.  Molecularly imprinted electrochemical sensor for propyl gallate based on PtAu bimetallic nanoparticles modified graphene-carbon nanotube composites. , 2015, Biosensors & bioelectronics.

[10]  D. Zhao,et al.  New faces of porous Prussian blue: interfacial assembly of integrated hetero-structures for sensing applications. , 2015, Chemical Society reviews.

[11]  Santanu Patra,et al.  RETRACTED: Bimetallic magnetic nanoparticle as a new platform for fabrication of pyridoxine and pyridoxal-5'-phosphate imprinted polymer modified high throughput electrochemical sensor. , 2015, Biosensors & bioelectronics.

[12]  P. He,et al.  Direct Electrochemical Detection of Oligonucleotide Hybridization on Poly(thionine) Film , 2005 .

[13]  Leyu Wang,et al.  Fluorescent nanosensors via photoinduced polymerization of hydrophobic inorganic quantum dots for the sensitive and selective detection of nitroaromatics. , 2015, Analytical chemistry.

[14]  Yu Zhang,et al.  Poly(ionic liquids) functionalized polypyrrole/graphene oxide nanosheets for electrochemical sensor to detect dopamine in the presence of ascorbic acid. , 2015, Biosensors & bioelectronics.

[15]  Chen Li,et al.  Imprinted electrochemical sensor for dopamine recognition and determination based on a carbon nanotube/polypyrrole film , 2012 .

[16]  Hongying Liu,et al.  Fabrication of polythionine/NPAu/MWNTs modified electrode for simultaneous determination of adenine and guanine in DNA , 2008 .

[17]  Fan Yang,et al.  Preparation of poly(thionine) modified screen-printed carbon electrode and its application to determine NADH in flow injection analysis system. , 2003, Biosensors & bioelectronics.

[18]  Ping Yang,et al.  Simultaneous determination of hydroquinone and catechol using poly(p‐aminobenzoic acid) modified glassy carbon electrode , 2009 .

[19]  Md. Mahbubur Rahman,et al.  Highly sensitive and simultaneous determination of hydroquinone and catechol at poly(thionine) modified glassy carbon electrode , 2011 .

[20]  Qingsheng Wu,et al.  Direct simultaneous determination of dihydroxybenzene isomers at C-nanotube-modified electrodes by derivative voltammetry , 2005 .

[21]  C. Perrin,et al.  Quantification of synthetic phenolic antioxidants in dry foods by reversed-phase HPLC with photodiode array detection , 2002 .

[22]  Yingchun Li,et al.  Molecularly imprinted polymer decorated nanoporous gold for highly selective and sensitive electrochemical sensors , 2015, Scientific Reports.

[23]  A. Gómez-Hens,et al.  Simultaneous kinetic determination of butylated hydroxyanisole and propyl gallate by coupling stopped-flow mixing technique and diode-array detection , 1997 .

[24]  I. Castanheira,et al.  Analytical strategies to evaluate antioxidants in food: a review , 2010 .

[25]  Hao Dai,et al.  Development of novel molecularly imprinted magnetic solid-phase extraction materials based on magnetic carbon nanotubes and their application for the determination of gatifloxacin in serum samples coupled with high performance liquid chromatography. , 2013, Journal of chromatography. A.

[26]  Yufang Liu,et al.  A fiber link equipment for the optical rotation measuring based on AC-DC modulation magneto-optical effect , 2016 .

[27]  A. Gómez-Hens,et al.  Determination of antioxidant additives in foodstuffs by direct measurement of gold nanoparticle formation using resonance light scattering detection. , 2011, Analytica chimica acta.

[28]  Min Liu,et al.  Highly selective and sensitive determination of dopamine by the novel molecularly imprinted poly(nicotinamide)/CuO nanoparticles modified electrode. , 2015, Biosensors & bioelectronics.

[29]  María Cristina González,et al.  A composite amperometric tyrosinase biosensor for the determination of the additive propyl gallate in foodstuffs , 2005 .

[30]  Zian Lin,et al.  Highly sensitive protein molecularly imprinted electro-chemical sensor based on gold microdendrites electrode and prussian blue mediated amplification. , 2013, Biosensors & bioelectronics.

[31]  G. Wulff.  Molecular Imprinting in Cross‐Linked Materials with the Aid of Molecular Templates— A Way towards Artificial Antibodies , 1995 .

[32]  H. Qi,et al.  Simultaneous Determination of Hydroquinone and Catechol at a Glassy Carbon Electrode Modified with Multiwall Carbon Nanotubes , 2005 .