Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature

[1]  M. Nedergaard,et al.  Glymphatic influx and clearance are accelerated by neurovascular coupling , 2023, Nature Neuroscience.

[2]  Di Wu,et al.  Effects of increased intracranial pressure on cerebrospinal fluid influx, cerebral vascular hemodynamic indexes, and cerebrospinal fluid lymphatic efflux , 2022, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  J. Iliff,et al.  Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain , 2022, Neurophotonics.

[4]  Yu-guang Liu,et al.  Changes of arachnoid granulations after subarachnoid hemorrhage in cynomolgus monkeys. , 2021, Journal of integrative neuroscience.

[5]  S. P. das Neves,et al.  CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges , 2021, Frontiers in Pharmacology.

[6]  D. Holtzman,et al.  Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy , 2021, Nature.

[7]  P. Subramanian,et al.  Prostaglandin analog effects on cerebrospinal fluid reabsorption via nasal mucosa , 2021, bioRxiv.

[8]  Jasmin Herz,et al.  Functional characterization of the dural sinuses as a neuroimmune interface , 2021, Cell.

[9]  Steven T. Proulx Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics , 2021, Cellular and Molecular Life Sciences.

[10]  R. Deane,et al.  Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging , 2020, Fluids and barriers of the CNS.

[11]  Jun Pyo Kim,et al.  Cerebrospinal Fluid Biomarkers for the Diagnosis and Classification of Alzheimer's Disease Spectrum , 2020, Journal of Korean medical science.

[12]  Ian F. Harrison,et al.  Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model , 2020, Brain : a journal of neurology.

[13]  M. McConnell,et al.  Enhanced meningeal lymphatic drainage ameliorates neuroinflammation and hepatic encephalopathy in cirrhotic rats , 2020, bioRxiv.

[14]  F. Tang,et al.  Meningeal lymphatic vessels regulate brain tumor drainage and immunity , 2020, Cell Research.

[15]  David Kleinfeld,et al.  Cerebrospinal fluid influx drives acute ischemic tissue swelling , 2020, Science.

[16]  P. Eide,et al.  Cerebrospinal fluid tracer efflux to parasagittal dura in humans , 2020, Nature Communications.

[17]  A. Iwasaki,et al.  VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours , 2020, Nature.

[18]  I. Smirnov,et al.  Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis , 2019, Nature Communications.

[19]  M. Lequin,et al.  MRI-guided definition of cerebrospinal fluid distribution around cranial and sacral nerves: implications for brain tumors and craniospinal irradiation , 2019, Acta oncologica.

[20]  Ji Hoon Ahn,et al.  Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid , 2019, Nature.

[21]  E. Kalso,et al.  Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs. , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[22]  H. Kunte,et al.  The effect of CSF drain on the optic nerve in idiopathic intracranial hypertension , 2019, The journal of headache and pain.

[23]  M. Diouf,et al.  Decreased Cerebrospinal Fluid Flow Is Associated With Cognitive Deficit in Elderly Patients , 2019, Front. Aging Neurosci..

[24]  D. Holtzman,et al.  Dural lymphatics regulate clearance of extracellular tau from the CNS , 2019, Molecular Neurodegeneration.

[25]  J. Williamson,et al.  Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial , 2019, JAMA.

[26]  I. Miinalainen,et al.  Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina , 2018, eLife.

[27]  Weiguo Peng,et al.  Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension , 2018, Nature Communications.

[28]  A. Bücker,et al.  Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain , 2018, Acta Neuropathologica.

[29]  Christopher C. Overall,et al.  Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease , 2018, Nature.

[30]  A. Ranjan,et al.  Effect of dexmedetomidine on intracranial pressures during laparoscopic surgery: A randomized, placebo-controlled trial , 2018, Journal of anaesthesiology, clinical pharmacology.

[31]  Scott T. Acton,et al.  Functional aspects of meningeal lymphatics in aging and Alzheimer’s disease , 2018, Nature.

[32]  Nanhong Lou,et al.  Cannula Implantation into the Cisterna Magna of Rodents. , 2018, Journal of visualized experiments : JoVE.

[33]  D. Čížková,et al.  Dynamics of Evans blue clearance from cerebrospinal fluid into meningeal lymphatic vessels and deep cervical lymph nodes , 2018, Neurological research.

[34]  K. Alitalo,et al.  Development and plasticity of meningeal lymphatic vessels , 2017, The Journal of experimental medicine.

[35]  M. Detmar,et al.  Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice , 2017, Nature Communications.

[36]  K. Zaghloul,et al.  Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI , 2017, eLife.

[37]  M. Nedergaard,et al.  Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. , 2017, The Journal of clinical investigation.

[38]  S. Mayer,et al.  Paradoxical cerebrovascular hemodynamic changes with nicardipine. , 2017, Journal of neurosurgery.

[39]  Byron Ballou,et al.  Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules , 2017, Proceedings of the National Academy of Sciences.

[40]  A. Louveau,et al.  How Do Meningeal Lymphatic Vessels Drain the CNS? , 2016, Trends in Neurosciences.

[41]  Mark H. Wilson,et al.  Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressure , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[42]  J. Iliff,et al.  Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease. , 2016, Biochimica et biophysica acta.

[43]  M. Detmar,et al.  A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules , 2015, The Journal of experimental medicine.

[44]  Timothy J Keyes,et al.  Structural and functional features of central nervous system lymphatics , 2015, Nature.

[45]  Maiken Nedergaard,et al.  Impairment of paravascular clearance pathways in the aging brain , 2014, Annals of neurology.

[46]  Hannu Sorvoja,et al.  Measurement of cerebral blood flow and metabolism using high power light-emitting diodes , 2014 .

[47]  Daniel J. R. Christensen,et al.  Sleep Drives Metabolite Clearance from the Adult Brain , 2013, Science.

[48]  S. Stinnett,et al.  Cerebrospinal Fluid Pressure Decreases with Older Age , 2012, PloS one.

[49]  G. E. Vates,et al.  A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β , 2012, Science Translational Medicine.

[50]  Marek Czosnyka,et al.  The monitoring of relative changes in compartmental compliances of brain , 2009, Physiological measurement.

[51]  J. Drummond,et al.  Effect of Dexmedetomidine on Cerebral Blood Flow Velocity, Cerebral Metabolic Rate, and Carbon Dioxide Response in Normal Humans , 2008, Anesthesiology.

[52]  Catherine Gondry-Jouet,et al.  Aging Effects on Cerebral Blood and Cerebrospinal Fluid Flows , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[53]  M. Johnston,et al.  Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species , 2004, Cerebrospinal Fluid Research.

[54]  M. Johnston,et al.  Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[55]  M. Johnston,et al.  Cerebrospinal fluid outflow resistance in sheep: impact of blocking cerebrospinal fluid transport through the cribriform plate , 2002, Neuropathology and applied neurobiology.

[56]  M. Boulton,et al.  Raised intracranial pressure increases CSF drainage through arachnoid villi and extracranial lymphatics. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[57]  E. Rubenstein Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged , 1998, The Lancet.

[58]  H. Fukuyama,et al.  Effect of nicardipine on cerebral blood flow in hypertensive patients with internal carotid artery occlusion: a PET study. , 1997, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[59]  R W McPherson,et al.  Pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat. , 1997, The American journal of physiology.

[60]  J. Kaye,et al.  Cerebrospinal fluid production is reduced in healthy aging , 1990, Neurology.

[61]  K. Omote,et al.  The Effects of Nicardipine on Cerebrospinal Fluid Pressure in Humans , 1986, Anesthesia and analgesia.

[62]  M. Gaab,et al.  Intracranial effects of nicardipine. , 1985, British journal of clinical pharmacology.

[63]  H. Cserr,et al.  Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit. , 1981, The American journal of physiology.

[64]  H. Turndorf,et al.  Intracranial pressure changes induced by sodium nitroprusside in patients with intracranial mass lesions. , 1978, Journal of neurosurgery.

[65]  D. Potts,et al.  Effect of positional changes and jugular vein compression on the pressure gradient across the arachnoid villi and granulations of the dog. , 1973, Journal of neurosurgery.

[66]  L. B. Flexner Some Problems of the Origin, Circulation and Absorption of the Cerebrospinal Fluid , 1933, The Quarterly Review of Biology.

[67]  F. Jessen,et al.  Cerebrospinal Fluid Biomarkers and Clinical Progression in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment. , 2017, Journal of Alzheimer's disease : JAD.

[68]  J. Pickard,et al.  Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury , 2006, Neurocritical care.

[69]  J. Levy Management of systemic and pulmonary hypertension. , 2005, Texas Heart Institute journal.

[70]  G. Maira,et al.  Sodium nitroprusside and intracranial pressure , 2005, Acta Neurochirurgica.

[71]  M. Johnston,et al.  Integrating the roles of extracranial lymphatics and intracranial veins in cerebrospinal fluid absorption in sheep. , 2004, Microvascular research.

[72]  Y. Otsuki,et al.  Immunohistochemical differentiation between lymphatic vessels and blood vessels--use of anti-basement membrane antibodies and anti-factor VIII-related antigen. , 1990, Archives of histology and cytology.

[73]  T. Takenaka,et al.  Cerebrovascular effects of YC-93, a new vasodilator, in dogs, monkeys and human patients. , 1979, International journal of clinical pharmacology and biopharmacy.

[74]  W. le Gros Clark On the Pacchionian Bodies. , 2022, Journal of anatomy.