Three-dimensional computer simulation of the cardiac system

An integrated approach to modeling the cardiac system is described and related to physiological measurements and other model approaches. The model is composed of a number of parts that will ultimately be used as a tool to study the various functions of the cardiac system. The 3-D geometry of the LV is reconstructed by using a helical coordinate system which provides a quantitative tool for shape description and analysis. Analysis of the regular geometry may be achieved using either the analytical helical system or a finite element technique. A simplified geometry is used to study the physiological interrelationship between the global ventricular function and the transmural temporal distribution of parameters which relate to mechanics, perfusion, energetics, and temperature in the myocardium. Transmural electrical activation maps are calculated based on analytical as well as a finite-element approach, eventually to be used in combination with the mechanical model to study LV contraction. >

[1]  R Gorlin,et al.  Cardiac shape and function in aortic valve disease: physiologic and clinical implications. , 1977, The American journal of cardiology.

[2]  N. Silverman,et al.  Cross sectional echocardiographic assessment of cardiac chamber size and ejection fraction in children. , 1984, Ultrasound in medicine & biology.

[3]  J Mazumdar,et al.  Three dimensional reconstruction of the left ventricle from four anatomically defined apical two-dimensional echocardiographic views. , 1984, Acta cardiologica.

[4]  Samuel Sideman,et al.  Spatial and temporal temperature distribution in the healthy and locally diseased wall of the heart , 1986 .

[5]  B. M. Steinhaus,et al.  SIMULATION OF ACTIVATION SEQUENCE EFFECTS IN HEART TISSUE. , 1983 .

[6]  J. Spear,et al.  The effects of procainamide on conduction in anisotropic canine ventricular myocardium. , 1986, Circulation.

[7]  J D Laird,et al.  Diastolic‐Systolic Coronary Flow Differences are Caused by Intramyocardial Pump Action in the Anesthetized Dog , 1981, Circulation research.

[8]  N Westerhof,et al.  Heat transport in the canine left ventricular wall. , 1984, The American journal of physiology.

[9]  K Sagawa,et al.  Contractility-dependent curvilinearity of end-systolic pressure-volume relations. , 1987, The American journal of physiology.

[10]  A. Wilde,et al.  Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart. , 1986, Circulation.

[11]  C. Feldman,et al.  Quantitative Detection of Regional Left Ventricular Contraction Abnormalities by Two‐dimensional Echocardiography.: I. Analysis of Methods , 1981, Circulation.

[12]  M. Perl,et al.  Simulation of the mechanics of an infarcted left ventricle , 1987 .

[13]  T. Musha,et al.  Three-Dimensional Simulation of the Ventricular Depolarization and Repolarization Processes and Body Surface Potentials: Nornal Heart and Bundle Branch Block , 1987, IEEE Transactions on Biomedical Engineering.

[14]  A. M. Scher,et al.  Influence of Cardiac Fiber Orientation on Wavefront Voltage, Conduction Velocity, and Tissue Resistivity in the Dog , 1979, Circulation research.

[15]  F. Klocke,et al.  Control of coronary blood flow. , 1980, Annual review of medicine.

[16]  D. Adam,et al.  The role of distributed conduction velocities in simulated epicardial activation maps , 1987 .

[17]  S Sideman,et al.  Left Ventricular Mechanics Related to the Local Distribution of Oxygen Demand Throughout the Wall , 1986, Circulation research.

[18]  B. Taccardi,et al.  Potential Fields on the Ventricular Surface of the Exposed Dog Heart during Normal Excitation , 1983, Circulation research.

[19]  G. Elzinga,et al.  Temperature Distribution and Transport of Heat in the Canine Myocardium , 1983 .

[20]  R. Barr,et al.  Analysis of Ventricular Activation and Repolarization from Intramural and Epicardial Potential Distributions for Ectopic Beats in the Intact Dog , 1975, Circulation research.

[21]  Samuel Sideman,et al.  3-D simulation of left ventricular contraction combining myocardial mechanics and electrical activation , 1987 .

[22]  Ramesh M. Gulrajani,et al.  Computer Simulation of the Wolff-Parkinson-White Preexcitation Syndrome with a Modified Miller-Geselowitz Heart Model , 1986, IEEE Transactions on Biomedical Engineering.

[23]  M. Quiñones,et al.  Quantification of Left Ventricular Volumes by Two‐dimensional Echocardiograph: A Simplified and Accurate Approach , 1983, Circulation.

[24]  W. Moritz,et al.  An Ultrasonic Technique for Imaging the Ventricle in Three Dimensions and Calculating Its Volume , 1983, IEEE Transactions on Biomedical Engineering.

[25]  H Suga,et al.  Effect of Positive Inotropic Agents on the Relation between Oxygen Consumption and Systolic Pressure Volume Area in Canine Left Ventricle , 1983, Circulation research.

[26]  E L Ritman,et al.  Subtraction Gated Computed Tomography with the Dynamic Spatial Reconstructor: Simultaneous Evaluation of Left and Right Heart from Single Right‐Sided Bolus Contrast Medium Injection , 1984, Journal of computer assisted tomography.

[27]  D. Durrer,et al.  Total Excitation of the Isolated Human Heart , 1970, Circulation.

[28]  S Sideman,et al.  Time-dependent coronary blood flow distribution in left ventricular wall. , 1987, The American journal of physiology.

[29]  S Sideman,et al.  Source parameters of the left ventricle related to the physiological characteristics of the cardiac muscle. , 1986, Biophysical journal.

[30]  Samuel Sideman,et al.  Heat transfer and temperature profiles during ischemia and infarction in the left ventricular wall , 1987 .

[31]  Samuel Sideman,et al.  An Analytical Descrptor of Three-Dimensional Geometry: Application to the Analysis of the Left Ventricle Shape and Contraction , 1987, IEEE Transactions on Biomedical Engineering.

[32]  N Westerhof,et al.  Left Ventricular Energetics: Heat Loss and Temperature Distribution of Canine Myocardium , 1982, Circulation research.

[33]  D G Gibson,et al.  Continuous assessment of left ventricular shape in man. , 1975, British heart journal.

[34]  D. D. Streeter,et al.  Engineering Mechanics for Successive States in Canine Left Ventricular Myocardium: II. Fiber Angle and Sarcomere Length , 1973, Circulation research.

[35]  Samuel Sideman,et al.  Temperature distribution within the left ventricular wall of the heart , 1985 .

[36]  W L Maughan,et al.  Abnormalities of Dynamic Ventricular Shape Change in Patients With Aortic and Mitral Valvular Regurgitation: Assessment by Fourier Shape Analysis and Global Geometric Indexes , 1988, Circulation research.

[37]  J I Hoffman,et al.  Determinants and prediction of transmural myocardial perfusion. , 1978, Circulation.

[38]  M. Marcus,et al.  Precision of measurements of right and left ventricular volume by cine computed tomography. , 1986, Circulation.

[39]  T. Sano,et al.  Directional Difference of Conduction Velocity in the Cardiac Ventricular Syncytium Studied by Microelectrodes , 1959, Circulation research.

[40]  E S Kirk,et al.  Inhibition of Coronary Blood Flow by a Vascular Waterfall Mechanism , 1975, Circulation research.

[41]  I. Mirsky,et al.  The role of mathematical models in an assessment of myocardial function , 1985 .

[42]  R. Beyar,et al.  A Computer Study of the Left Ventricular Performance Based on Fiber Structure, Sarcomere Dynamics, and Transmural Electrical Propagation Velocity , 1984, Circulation research.

[43]  K. Jan,et al.  Distribution of myocardial stress and its influence on coronary blood flow. , 1985, Journal of biomechanics.