Effects of work and acute beta‐receptor blockade on myocardial noradrenaline release in congestive cardiomyopathy

Systemic hemodynamic changes and noradrenaline concentrations in coronary sinus blood were studied at rest and during work before and after acute beta‐receptor blockade. Patients with congestive cardiomyopathy were compared to patients with primary valvular diseases and to healthy subjects. Noradrenaline concentrations were higher in coronary sinus blood than in arterial blood and increased after beta blockade and during work. Noradrenaline concentrations were more increased in patients with more pronounced myocardial failure and did not seem to separate patients with congestive cardiomyopathy from those with valvular disease. Patients with congestive cardiomyopathy showed a good hemodynamic tolerance toward acute beta blockade.

[1]  K. Swedberg,et al.  PROLONGATION OF SURVIVAL IN CONGESTIVE CARDIOMYOPATHY BY BETA-RECEPTOR BLOCKADE , 1979, The Lancet.

[2]  J. A. Thomas,et al.  Plasma norepinephrine in congestive heart failure. , 1978, The American journal of cardiology.

[3]  S. Simonsen.  Effect of atenolol (ICI 66 082) on coronary haemodynamics in man. , 1977, British heart journal.

[4]  I. Kopin,et al.  Dopamine-beta-hydroxylase activity and catecholamine concentrations in plasma: experimental and essential hypertension. , 1977, Postgraduate medical journal.

[5]  B. Eriksson,et al.  Determination of adrenaline and noradrenaline in plasma by an isotope derivative method and ion pair liquid chromatography. , 1977, Acta pharmaceutica Suecica.

[6]  H. Mueller.  Propranolol in acute myocardial infarction in man. Effects of hemodynamics and myocardial oxygenation. , 2009, Acta medica Scandinavica. Supplementum.

[7]  M. Barrand,et al.  Catecholamines in blood , 1976, The Journal of pharmacy and pharmacology.

[8]  S. Adams,et al.  Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)‐isomer , 1976, The Journal of pharmacy and pharmacology.

[9]  R. Nadeau,et al.  Correlation between changes in endogenous catecholamine release from the heart and various physiological responses in anesthetized dogs. , 1976, Recent advances in studies on cardiac structure and metabolism.

[10]  N. Christensen,et al.  Catecholamines in plasma and urine in patients with essential hypertension determined by double-isotope derivative techniques. , 2009, Acta medica Scandinavica.

[11]  E. Varnauskas,et al.  Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy. , 1975, British heart journal.

[12]  M. Irving,et al.  Effects of β adrenergic blockade on plasma catecholamines in exercise , 1974, Nature.

[13]  Kyuhyun Wang,et al.  Effect of Propranolol on Myocardial Oxygen Consumption and Its Hemodynamic Correlates during Upright Exercise , 1973, Circulation.

[14]  R. Garcia,et al.  Pheochromocytoma masquerading as a cardiomyopathy. , 1972, The American journal of cardiology.

[15]  K. Ogawa,et al.  Cardiac catecholamine metabolism in heart failure. , 1971, Japanese circulation journal.

[16]  A. Sjoerdsma,et al.  Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs. , 1968, The Journal of clinical investigation.

[17]  E. Braunwald,et al.  CATECHOLAMINE EXCRETION AND CARDIAC STORES OF NOREPINEPHRINE IN CONGESTIVE HEART FAILURE. , 1965, The American journal of medicine.

[18]  A. Sjoerdsma,et al.  CHRONIC MEDICAL THERAPY FOR PHEOCHROMOCYTOMA; A REPORT OF FOUR CASES. , 1964, Annals of internal medicine.

[19]  Copeman Pw,et al.  LUNG CANCER AND SMOKING. , 1964 .

[20]  E. Braunwald,et al.  MYOCARDIAL NOREPINEPHRINE CONCENTRATION IN MAN. EFFECTS OF RESERPINE AND OF CONGESTIVE HEART FAILURE. , 1963, The New England journal of medicine.

[21]  Bishop Jm,et al.  CARDIAC OUTPUT AND REGIONAL BLOOD FLOW , 1963, The Ulster Medical Journal.