Comprehensive Non-contrast CT Imaging of the Vulnerable Patient

Atherosclerotic cardiovascular disease is the leading cause of death in developed countries. Every year, one million people in the US experience a heart attack or sudden cardiac death. A large percentage of these patients have no prior symptoms of any kind but suffer from silent heart disease, which may cause a heart attack at any time. Currently, there is no reliable screening method to identify the “vulnerable patient” who may have silent heart disease and therefore is at the risk of suffering a cardiovascular event such as a heart attack.

[1]  M. Budoff,et al.  Normal thoracic aorta diameter on cardiac computed tomography in healthy asymptomatic adults: impact of age and gender. , 2008, Academic radiology.

[2]  S. Blair,et al.  Coronary artery calcium score and coronary heart disease events in a large cohort of asymptomatic men and women. , 2005, American journal of epidemiology.

[3]  Arik Wolak,et al.  Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area. , 2008, JACC. Cardiovascular imaging.

[4]  C. Ozbakir,et al.  The Role of Valvular and Thoracic Aortic Calcifications in Distinction Between Ischemic and Nonischemic Cardiomyopathy , 2004, Angiology.

[5]  R. Kronmal,et al.  Multi-Ethnic Study of Atherosclerosis: objectives and design. , 2002, American journal of epidemiology.

[6]  M. Budoff,et al.  Effect of electrocardiogram triggering on reproducibility of coronary artery calcium scoring. , 2001, Radiology.

[7]  M. Budoff,et al.  Coronary artery motion in electron beam tomography. , 2000, Journal of computer assisted tomography.

[8]  J. Rumberger,et al.  A rosetta stone for coronary calcium risk stratification: agatston, volume, and mass scores in 11,490 individuals. , 2003, AJR. American journal of roentgenology.

[9]  D. Berman,et al.  Concordance of coronary artery calcium estimates between MDCT and electron beam tomography. , 2005, AJR. American journal of roentgenology.

[10]  K. Bae,et al.  Quantification of coronary artery calcium with multi-detector row CT: assessing interscan variability with different tube currents pilot study. , 2003, Radiology.

[11]  Y. Arad,et al.  Objectives Background Methods Results Conclusions , 2022 .

[12]  J. Gardin,et al.  Coronary artery calcium evaluation by electron beam computed tomography and its relation to new cardiovascular events. , 2000, The American journal of cardiology.

[13]  A Crispin,et al.  Coronary artery calcium measurement: agreement of multirow detector and electron beam CT. , 2001, AJR. American journal of roentgenology.

[14]  S. Grundy Primary prevention of coronary heart disease: integrating risk assessment with intervention. , 1999, Circulation.

[15]  J. Bland,et al.  Serial electron beam CT measurements of coronary artery calcium: Has your patient's calcium score actually changed? , 2005, AJR. American journal of roentgenology.

[16]  J. Takasu,et al.  Pericardial fat accumulation in men as a risk factor for coronary artery disease. , 2001, Atherosclerosis.

[17]  B. Thompson,et al.  Coronary artery calcium quantification at multi-detector row helical CT versus electron-beam CT. , 2004, Radiology.

[18]  D. Dey,et al.  Computer-aided detection and evaluation of lipid-rich plaque on noncontrast cardiac CT. , 2006, AJR. American journal of roentgenology.

[19]  Louis Evan Teichholz,et al.  Quantitative assessment of atherosclerosis by electron beam tomography. , 2002, The American journal of cardiology.

[20]  Matthew J Budoff,et al.  Expert review on coronary calcium , 2008, Vascular health and risk management.

[21]  Ioannis A. Kakadiaris,et al.  Automated segmentation of thoracic aorta in non-contrast CT images , 2008, 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro.

[22]  Moyses Szklo,et al.  Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). , 2008, Archives of internal medicine.

[23]  I. Kakadiaris,et al.  Computer-aided non-contrast CT-based quantification of pericardial and thoracic fat and their associations with coronary calcium and Metabolic Syndrome. , 2010, Atherosclerosis.

[24]  Jeroen J. Bax,et al.  Role of calcified spots detected by intravascular ultrasound in patients with ST-segment elevation acute myocardial infarction. , 2006, The American journal of cardiology.

[25]  D. Tanné,et al.  Spiral computed tomography evidence of close correlation between coronary and thoracic aorta calcifications. , 2004, Atherosclerosis.

[26]  Christophe Lenglet,et al.  ODF reconstruction in q-ball imaging with solid angle consideration , 2009, 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro.

[27]  James T. Willerson,et al.  Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells , 2000, Circulation.

[28]  Willi A Kalender,et al.  Coronary artery calcium: a multi-institutional, multimanufacturer international standard for quantification at cardiac CT. , 2007, Radiology.

[29]  Hajime Yamashita,et al.  Spotty Calcification Typifies the Culprit Plaque in Patients With Acute Myocardial Infarction: An Intravascular Ultrasound Study , 2004, Circulation.

[30]  R. Detrano,et al.  Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. , 2004, JAMA.

[31]  Hirofumi Anno,et al.  Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. , 2007, Journal of the American College of Cardiology.

[32]  D. Berman,et al.  Roles of nuclear cardiology, cardiac computed tomography, and cardiac magnetic resonance: Noninvasive risk stratification and a conceptual framework for the selection of noninvasive imaging tests in patients with known or suspected coronary artery disease. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[33]  Daniel S Berman,et al.  Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. , 2007, Journal of the American College of Cardiology.

[34]  R. Kronmal,et al.  Comparison of left ventricular size by computed tomography with magnetic resonance imaging measures of left ventricle mass and volumes: the multi-ethnic study of atherosclerosis. , 2008, Journal of cardiovascular computed tomography.

[35]  S. Yusuf,et al.  Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. , 2001, Circulation.

[36]  K M Kessler,et al.  Frequency of sudden cardiac death and profiles of risk. , 1997, The American journal of cardiology.

[37]  P. Ridker,et al.  C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. , 2000, The New England journal of medicine.

[38]  R. Detrano,et al.  The Association of Pericardial Fat With Calcified Coronary Plaque , 2008, Obesity.

[39]  C. Becker,et al.  Reproducibility of coronary calcium quantification in repeat examinations with retrospectively ECG-gated multisection spiral CT , 2002, European Radiology.

[40]  T. Pilgram,et al.  Coronary artery calcium: accuracy and reproducibility of measurements with multi-detector row CT--assessment of effects of different thresholds and quantification methods. , 2003, Radiology.

[41]  Maximilian Reiser,et al.  Pericardial Adipose Tissue Determined by Dual Source CT Is a Risk Factor for Coronary Atherosclerosis , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[42]  M. Budoff,et al.  Prognostic value of number and site of calcified coronary lesions compared with the total score. , 2008, JACC. Cardiovascular imaging.

[43]  G. Steinbeck,et al.  Prädiktion kardiovaskulàrer Ereignisse durch Koronarkalkbestimmung mit der Mehrzeilen-Computertomographie , 2005 .

[44]  J. Debatin,et al.  Radiation exposure during cardiac CT: effective doses at multi-detector row CT and electron-beam CT. , 2003, Radiology.

[45]  J. Erikssen,et al.  Heart volume and cardiovascular mortality. A 16 year follow-up study of 1984 healthy middle-aged men. , 1993, European heart journal.

[46]  R. Virmani,et al.  Sudden cardiac death. , 2001, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[47]  Ioannis A. Kakadiaris,et al.  Automated Pericardial Fat Quantification in CT Data , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[48]  R. Detrano,et al.  Quantification of coronary artery calcium using ultrafast computed tomography. , 1990, Journal of the American College of Cardiology.

[49]  Udo Hoffmann,et al.  Pericardial Fat, Visceral Abdominal Fat, Cardiovascular Disease Risk Factors, and Vascular Calcification in a Community-Based Sample: The Framingham Heart Study , 2008, Circulation.

[50]  D. Tanné,et al.  Calcification of the thoracic aorta by spiral computed tomography among hypertensive patients: associations and risk of ischemic cerebrovascular events. , 2007, International journal of cardiology.

[51]  T. Callister,et al.  Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method. , 1998, Radiology.

[52]  Y. Itzchak,et al.  Coronary calcium by spiral computed tomography predicts cardiovascular events in high-risk hypertensive patients , 2004, Journal of hypertension.

[53]  J. Takasu,et al.  Evaluation of morphological changes of the atherosclerotic aorta by enhanced computed tomography. , 1992, Atherosclerosis.

[54]  M. Budoff,et al.  Repeatability limits for measurement of coronary artery calcified plaque with cardiac CT in the Multi-Ethnic Study of Atherosclerosis. , 2008, AJR. American journal of roentgenology.

[55]  Michael McNitt-Gray,et al.  Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility--MESA study. , 2005, Radiology.

[56]  L. V. Van Hoe,et al.  Coronary artery calcium scoring using ECG-gated multidetector CT: effect of individually optimized image-reconstruction windows on image quality and measurement reproducibility. , 2003, AJR. American journal of roentgenology.

[57]  C. White,et al.  Determination of coronary calcium with Multi-slice Spiral Computed Tomography: a comparative study with Electron-beam CT , 2002, The International Journal of Cardiovascular Imaging.

[58]  Alexander Becker,et al.  Predictive value of coronary calcifications for future cardiac events in asymptomatic individuals. , 2008, American heart journal.

[59]  D. Berman,et al.  Prognostic value of cardiac risk factors and coronary artery calcium screening for all-cause mortality. , 2003, Radiology.

[60]  Robert Detrano,et al.  Combined Use of Computed Tomography Coronary Calcium Scores and C-Reactive Protein Levels in Predicting Cardiovascular Events in Nondiabetic Individuals , 2002, Circulation.

[61]  Kiang Liu,et al.  Electron-Beam Tomography Coronary Artery Calcium and Cardiac Events: A 37-Month Follow-Up of 5635 Initially Asymptomatic Low- to Intermediate-Risk Adults , 2003, Circulation.

[62]  T. Callister,et al.  Identification of patients at increased risk of first unheralded acute myocardial infarction by electron-beam computed tomography. , 2000, Circulation.

[63]  Y. Itani,et al.  Aortic calcification detected in a mass chest screening program using a mobile helical computed tomography unit. Relationship to risk factors and coronary artery disease. , 2004, Circulation journal : official journal of the Japanese Circulation Society.

[64]  W. L. Ooi,et al.  Cardiomegaly on chest x-ray: prognostic implications from a ten-year cohort study of elderly subjects: a report from the Bronx Longitudinal Aging Study. , 1992, American heart journal.

[65]  Moyses Szklo,et al.  Coronary calcium as a predictor of coronary events in four racial or ethnic groups. , 2008, The New England journal of medicine.

[66]  D. Dey,et al.  Automated Quantitation of Pericardiac Fat From Noncontrast CT , 2008, Investigative radiology.

[67]  M. Prokop,et al.  Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease. , 2008, Atherosclerosis.

[68]  Nancy R Cook,et al.  Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. , 2002, The New England journal of medicine.

[69]  M. Figley,et al.  Correlation between chest film and angiographic assessment of left ventricular size. , 1977, AJR. American journal of roentgenology.

[70]  Y. Arad,et al.  Prediction of coronary events with electron beam computed tomography. , 2000, Journal of the American College of Cardiology.

[71]  B. Sternfeld,et al.  Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. , 2000, JAMA.

[72]  Carl D Langefeld,et al.  Pericardial and Visceral Adipose Tissues Measured Volumetrically With Computed Tomography Are Highly Associated in Type 2 Diabetic Families , 2005, Investigative radiology.

[73]  Herbert Bruder,et al.  Advances in cardiac imaging with 16-section CT systems. , 2003, Academic radiology.

[74]  V F Froelicher,et al.  American College of Cardiology/American Heart Association Expert Consensus Document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease. , 2000, Journal of the American College of Cardiology.

[75]  N. Unwin,et al.  Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National , 2009 .

[76]  D. Levy,et al.  Prediction of coronary heart disease using risk factor categories. , 1998, Circulation.

[77]  P. Ridker,et al.  Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. , 1997, The New England journal of medicine.

[78]  D. Goff,et al.  Evaluation of subsecond gated helical CT for quantification of coronary artery calcium and comparison with electron beam CT. , 2000, AJR. American journal of roentgenology.

[79]  Antonio Colombo,et al.  From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. , 2003, Circulation.

[80]  Udo Hoffmann,et al.  Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. , 2008, European heart journal.

[81]  A. Hofman,et al.  Coronary Calcification Improves Cardiovascular Risk Prediction in the Elderly , 2005, Circulation.

[82]  Jonathan G Goldin,et al.  Assessment of Coronary Artery Disease by Cardiac Computed Tomography: A Scientific Statement From the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiolog , 2006, Circulation.

[83]  E. Boerwinkle,et al.  From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. , 2003, Circulation.

[84]  R. Morin,et al.  Radiation dose in computed tomography of the heart. , 2003, Circulation.

[85]  Irwin Feuerstein,et al.  Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project. , 2005, Journal of the American College of Cardiology.