Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

Plasma levels of insulin-like growth factor I (IGF-I) have been associated with risk of several cancers. Although protein-calorie malnutrition is known to decrease IGF-I levels, few published studies have related diet to IGF-I levels in well-nourished humans. We examined the cross-sectional association of plasma IGF-I and IGF-binding protein 3 (IGFBP-3) levels with intakes of alcohol, energy, macronutrients, micronutrients, and specific foods in 1037 healthy women. Adjusted mean hormone levels across categories of dietary variables were calculated by linear regression. Results were adjusted for non-dietary factors found to be associated with IGF levels. Total energy intake was positively associated with IGF-I levels when adjusted for covariates. Adjusted mean levels of IGF-I (ng/ml) across increasing quintiles of energy intake were 181, 185, 191, 199, and 195 (P for the linear trend = 0.006). In other multivariate analyses, energy-adjusted fat and carbohydrate intake had no association with IGF-I levels. The most consistent finding was a positive association between protein intake with circulating IGF-I concentration (174, 188, 201, 192, and 196 ng/ml across quintiles of protein intake; P = 0.002), which was largely attributable to milk intake. Adjusted mean levels of IGF-I (ng/ml) across increasing quartiles of milk intake were 183, 189, 188, and 200 (P = 0.01). Higher fat intake, in particular saturated fat, was associated with lower levels of IGFBP-3. We conclude that higher energy, protein, and milk intakes were associated with higher levels of IGF-I. These associations raise the possibility that diet could affect cancer risk through influencing IGF-I level.

[1]  Adam D. Seal,et al.  Nutritional Epidemiology. , 2018, Current developments in nutrition.

[2]  Kathleen M. Fairfield,et al.  A prospective study of dietary lactose and ovarian cancer , 2004, International journal of cancer.

[3]  S. Hankinson,et al.  Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[4]  M. Stampfer,et al.  Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. , 2001, Journal of the National Cancer Institute.

[5]  J. Manson,et al.  Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal women. , 2001, The American journal of clinical nutrition.

[6]  R. Shore,et al.  Serum insulin‐like growth factor‐I and breast cancer , 2000, International journal of cancer.

[7]  J. Manson,et al.  Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  E. Metter,et al.  Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer. , 2000, The Journal of clinical endocrinology and metabolism.

[9]  T. Rohan,et al.  Role of the insulin-like growth factor family in cancer development and progression. , 2000, Journal of the National Cancer Institute.

[10]  C. Potten,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Circulating Insulin-Like Growth Factor II and , 2000 .

[11]  Catherine S. Williams,et al.  Secretion of Insulin-Like Growth Factor-II into Bile of Rats of Different Ages , 2000, Neonatology.

[12]  W C Willett,et al.  A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. , 2000, The American journal of clinical nutrition.

[13]  M. Pollak Insulin-like growth factor physiology and cancer risk. , 2000, European journal of cancer.

[14]  W. Willett,et al.  A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[15]  G. Verbeke,et al.  Down‐Regulation of the Serum Stimulatory Components of the Insulin‐like Growth Factor (IGF) System (IGF‐I, IGF‐II, IGF Binding Protein [BP]‐3, and IGFBP‐5) in Age‐Related (Type II) Femoral Neck Osteoporosis , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  S. Oparil,et al.  Dietary changes favorably affect bone remodeling in older adults. , 1999, Journal of the American Dietetic Association.

[17]  C. Mantzoros,et al.  IGF‐I and IGF‐II in relation to colorectal cancer , 1999, International journal of cancer.

[18]  R. Goldbohm,et al.  Animal products, calcium and protein and prostate cancer risk in the Netherlands Cohort Study , 1999, British Journal of Cancer.

[19]  G A Colditz,et al.  Association of dietary intake of fat and fatty acids with risk of breast cancer. , 1999, JAMA.

[20]  L. Signorello,et al.  Diet and cancer of the prostate: a case‐control study in Greece , 1999, International journal of cancer.

[21]  E. Giovannucci,et al.  Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. , 1999, Journal of the National Cancer Institute.

[22]  M. Spitz,et al.  Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. , 1999, Journal of the National Cancer Institute.

[23]  H. Adami,et al.  Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden) , 1998, Cancer Causes & Control.

[24]  S. Mohan,et al.  Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. , 1998, The American journal of clinical nutrition.

[25]  C. Mantzoros,et al.  Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. , 1998, Journal of the National Cancer Institute.

[26]  David J Hunter,et al.  Circulating concentrations of insulin-like growth factor I and risk of breast cancer , 1998, The Lancet.

[27]  D. Grobbee,et al.  Serum total IGF-I, free IGF-I, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[28]  Meir J. Stampfer,et al.  Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study , 1998 .

[29]  J. French,et al.  Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. , 1997, Cancer research.

[30]  E. Barrett-Connor,et al.  Epidemiology of insulin-like growth factor-I in elderly men and women. The Rancho Bernardo Study. , 1997, American journal of epidemiology.

[31]  O. Koldovský,et al.  Growth of artificially fed infant rats: effect of supplementation with insulin-like growth factor I. , 1997, The American journal of physiology.

[32]  J. Kaprio,et al.  Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3. , 1996, The Journal of clinical investigation.

[33]  K. Michaelsen,et al.  Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. , 1995, The Journal of clinical endocrinology and metabolism.

[34]  D. Clemmons,et al.  Insulin-like growth factors and their binding proteins: biological actions. , 1995, Endocrine reviews.

[35]  J. Ketelslegers,et al.  Nutritional regulation of the insulin-like growth factors. , 1994, Endocrine reviews.

[36]  C. Welsch,et al.  Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique. , 1992, Cancer research.

[37]  T. Wolever,et al.  The glycemic index: methodology and clinical implications. , 1991, The American journal of clinical nutrition.

[38]  D. Straus,et al.  Effect of dietary protein deprivation on insulin-like growth factor (IGF)-I and -II, IGF binding protein-2, and serum albumin gene expression in rat. , 1990, Endocrinology.

[39]  J C Juskevich,et al.  Bovine growth hormone: human food safety evaluation. , 1990, Science.

[40]  C. la Vecchia,et al.  Nutrition, social factors and prostatic cancer in a Northern Italian population. , 1986, British Journal of Cancer.

[41]  C. Elson,et al.  Net energy effects of dietary fat on chemically induced mammary carcinogenesis in F344 rats. , 1986, Journal of the National Cancer Institute.

[42]  W. Willett,et al.  Reproducibility and validity of a semiquantitative food frequency questionnaire. , 1985, American journal of epidemiology.

[43]  S. R. Searle,et al.  Population Marginal Means in the Linear Model: An Alternative to Least Squares Means , 1980 .

[44]  A. Tannenbaum The Dependence of the Genesis of Induced Skin Tumors on the Caloric Intake during Different Stages of Carcinogenesis , 1944 .

[45]  C. Mantzoros,et al.  Dietary F at a nd C arbohydrates A re I ndependently A ssociated With C irculating I nsulin-Like G rowth F actor 1 a nd Insulin-Like G rowth F actor-Binding P rotein 3 Concentrations i n H ealthy A dults , 1999 .

[46]  Stampfer,et al.  Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. , 1999, Journal of the National Cancer Institute.

[47]  E. Giovannucci,et al.  Diet, nutrition, and prostate cancer. , 1998, Annual review of nutrition.

[48]  C. la Vecchia,et al.  Diet and prostatic cancer: a case-control study in northern Italy. , 1992, Nutrition and cancer.

[49]  C. la Vecchia,et al.  Dairy products and the risk of prostatic cancer. , 1991, Oncology.

[50]  C. Ip Quantitative assessment of fat and calorie as risk factors in mammary carcinogenesis in an experimental model. , 1990, Progress in clinical and biological research.