Gene silencing: Cosuppression at a distance

When a plant carries a transgenic copy of an endogenous gene, both genes may be silenced. This 'cosuppression' can occur not only within individual cells, but also in distant cells through an agent that apparently moves through the plant's phloem.

[1]  M. Matzke,et al.  How and Why Do Plants Inactivate Homologous (Trans)genes? , 1995, Plant physiology.

[2]  H. Vaucheret,et al.  Systemic acquired silencing: transgene‐specific post‐transcriptional silencing is transmitted by grafting from silenced stocks to non‐silenced scions , 1997, The EMBO journal.

[3]  G. Pearce,et al.  A Polypeptide from Tomato Leaves Induces Wound-Inducible Proteinase Inhibitor Proteins , 1991, Science.

[4]  D. Ginty,et al.  Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis , 1997 .

[5]  P. Bingham,et al.  Cosuppression Comes to the Animals , 1997, Cell.

[6]  E. Selker.  Epigenetic phenomena in filamentous fungi: useful paradigms or repeat-induced confusion? , 1997, Trends in genetics : TIG.

[7]  J. Mol,et al.  Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. , 1990, The Plant cell.

[8]  Olivier Voinnet,et al.  Systemic signalling in gene silencing , 1997, Nature.

[9]  M. Metzlaff,et al.  RNA-Mediated RNA Degradation and Chalcone Synthase A Silencing in Petunia , 1997, Cell.

[10]  K. Kasschau,et al.  Cell-to-Cell and Long-Distance Transport of Viruses in Plants. , 1996, The Plant cell.

[11]  C. Napoli,et al.  Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans. , 1990, The Plant cell.

[12]  D. Baulcombe,et al.  A similarity between viral defense and gene silencing in plants. , 1997, Science.

[13]  D. Baulcombe.  Mechanisms of Pathogen-Derived Resistance to Viruses in Transgenic Plants. , 1996, The Plant Cell.